1. Prognosis and antiplatelet therapy of small single subcortical infarcts in penetrating artery territory: a post hoc analysis of the Third China National Stroke Registry
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Xu Zhang, Yongjun Wang, Kangning Chen, Lianbo Gao, Ye Tian, Xu Chen, Yi Guo, Benyan Luo, Yan Wang, Jian Wu, Xiaohong Li, An-Xin Wang, Yong-Jun Wang, Qiang Dong, Huisheng Chen, Wei Wang, Zhengqi Lu, Jing Jing, Lijie Ren, Runqing Wang, Juan Feng, Zhangyong Xia, Hao Li, Lihua Wang, Qingwei Zhao, Hong Wang, Ting Wang, Jin Zhou, Xia Meng, Jun Wu, Qing Li, Shizheng Wu, Ping Zhang, Li-Ping Liu, Yi-long Wang, Ming Yu, Guohua Chen, Zhimin Wang, Jianhua Li, Yi Wang, Yi Yang, Xinsheng Han, Songdi Wu, Yongming Chen, Liang Zhao, Qiang Ma, Xiaoying Zhang, Mei Zhang, Limin Wang, Hui Liang, Liping Wang, Jun Zhou, Jie Lin, Yu Geng, Ning Wang, Yun Xu, Jinsheng Zeng, Huijuan Wang, Xueli Cai, Jia Yin, Jun Xu, Feng Qiu, Jun Zhao, Baojun Wang, Hainan Zhang, Zi-Xiao Li, Xing-Quan Zhao, Mingzhi Zhao, Yingchun Wu, Junling Zhang, Xuerong Qiu, Zhongping An, Wenjun Xue, Lili Zhao, Hongyan Li, Junfeng Shi, Mingzhen Li, Tao Gong, Qi Fang, Liyan Liu, Jianfeng Wang, Guang Huang, Chun Wang, Yuwu Zhao, Lei Sheng, Lei Xia, Yan Fang, Xiaoxiang Peng, Yanling Wang, Yangmei Chen, Deqin Geng, Jinfeng Liu, Weirong Li, Yuqing Wei, Yu-Yuan Xu, Yi-Jun Zhang, Jilai Li, Maolin He, Quping Ouyang, Fengchun Yu, Chenlong Wang, Jinli Zhang, Wenqing Wu, Yaoyu Yu, Meiyun Zhang, Junyan Liu, Wanying Shi, Baoquan Lu, Lijun Geng, Shujuan Wang, Ruifang Liu, Fengli Zhao, Xinping Liu, Xuebing Sun, Tianyuan Li, Youming Wang, Xinxia He, Weiqiang Yuan, Ronghua Dou, Lihai Liu, Haisong Du, Cunrui Wang, Yu'an Zou, Xiaofei Chen, Fengyun Hu, Fanping He, Xingchen Wang, Hongjin Li, Mingzong Yan, Guiru Zhang, Yunlin Liu, Yuhui Han, Xianghong Meng, Hongtian Zhang, Congmin Ma, Gexia Liu, Wenxu Zheng, Haitao Chi, Hongbo Xiao, Lijun Xiao, Guozhong Li, Yulan Zhu, Yindong Yang, Xuhai Gong, Qunhui Liu, Shiping Gong, Hongbin Zhou, Haipeng Li, Yong You, Jinsheng Lin, Heqing Zhao, Aixia Zhuang, Kaifu Ke, Zhengxie Dong, Guiyun Cui, Liangqun Rong, Yi Wu, Weiguo Tang, Yanjiang Wang, Wenguang Bu, Xiaohua Cheng, An'ding Xu, Jifu Cai, Lvli Li, Li Pan; Yinzhou Wang, Jianping Niu, Liping Zhan, Li'e Wu, Li Liu; Yanru Zhao, Runxiu Zhu, Yanhui Du, Yongxia Wen, Yongcai Qu, Yuncheng Wu, Jianren Liu, Qingke Bai, Chaoming He, Weiwen Qiu, Shufang Yao, Xuwen Sun, Ligong Gao, Xianglin Chen, Qiuyan Shi, Zhaochen Li, Tianbao Chen, SuYun Yang, Yazhou Han, Xinxiao Wu, Beihai Jiang, Lizhong Li, Weidong Lou, Weiming Lan, Aihu Zheng, Qifu Bai, Lifang Luan, Liqing Yan, Yanxia Wang, Xuerong Huang, Xiangting Chai, Yanshu Liu, Liangjun You, Hongqin Yang, Dongfang Li, Linying Gui, Aisheng Wu, Jianling Zhang, Dengling Wang, Qinghua Zhang, Yunhong He, Ruiyou Guo, Jijun Teng, and Ping Lou
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background Small single subcortical infarction (SSSI) may be classified as parent artery disease-related or only branch involved according to the stenosis of parent artery. The study aimed to evaluate short-term and long-term prognoses and the effectiveness of antiplatelet therapy in SSSI.Methods We prospectively enrolled 2890 patients with SSSI from the Third China National Stroke Registry (CNSR-III) database from August 2015 to March 2018. We assessed clinical outcomes and antiplatelet treatment effects in patients with SSSI with and without parent artery stenosis (PAS) identified by magnetic resonance angiography.Results Among 2890 patients with SSSI in the perforator territory of the middle cerebral artery and the basilar artery, there were 680 (23.53%) patients with PAS and 2210 (76.47%) patients without PAS, respectively. After adjusting for potential confounders, the PAS group had a greater initial stroke severity (OR 1.262, 95% CI 1.058 to 1.505; p=0.0097) and a higher risk of ischaemic stroke recurrence at 3 months (OR 2.266, 95% CI 1.631 to 3.149; p
- Published
- 2022
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