1. Malignant prolongation of the QTc interval due to severe vitamin D deficiency: an unusual presentation
- Author
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Ashutosh Yadav, Soumitra S. Ghosh, Sourabh Agstam, and Preeti Gupta
- Subjects
Adult ,medicine.medical_specialty ,Long QT syndrome ,Reference range ,Torsades de pointes ,Case Report ,030204 cardiovascular system & hematology ,QT interval ,vitamin D deficiency ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Palpitations ,Medicine ,Humans ,Hypocalcaemia ,cardiovascular diseases ,030212 general & internal medicine ,Vitamin D ,Presyncope ,Hypocalcemia ,business.industry ,General Medicine ,Vitamins ,medicine.disease ,Vitamin D Deficiency ,Adrenergic beta-1 Receptor Antagonists ,Calcium Gluconate ,Long QT Syndrome ,cardiovascular system ,Cardiology ,Electrocardiography, Ambulatory ,Calcium ,Female ,medicine.symptom ,business ,Metoprolol - Abstract
Long QT syndrome with Torsades de Pointes (TdP) is a life-threatening polymorphic ventricular arrhythmia. The corrected QT (QTc) prolongation >500 milliseconds (ms) has been associated with TdP. Hypocalcaemia due to severe vitamin D deficiency is an uncommon cause of acquired long QT. We hereby present a case of a 40-year-old woman with sensorineural deafness and having symptoms of palpitations and presyncope. She had a QTc interval of 556 ms (reference range, QTc 451โ470 ms in adult healthy woman) on 24-hour Holter analysis. Genetic analysis for congenital long QT syndrome was negative. She was diagnosed with severe hypocalcaemia secondary to severe vitamin D deficiency. After treatment with intravenous calcium gluconate, followed by oral vitamin D and calcium supplementation, the QTc became normalised and no further episode of palpitations or presyncope occurred. The causes of vitamin D deficiency was due to inadequate exposure to sunlight and a strict vegan diet.
- Published
- 2022