1. Lymphoproliferative disorder in a lung transplant recipient.
- Author
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Haji HA, Corwin DS, So JY, and Reed RM
- Subjects
- Abdominal Pain etiology, Aged, Herpesvirus 4, Human isolation & purification, Humans, Immunologic Factors administration & dosage, Immunologic Factors adverse effects, Intestinal Perforation chemically induced, Intestinal Perforation diagnostic imaging, Intestinal Perforation etiology, Lymphoproliferative Disorders diagnosis, Lymphoproliferative Disorders drug therapy, Lymphoproliferative Disorders etiology, Male, Rituximab administration & dosage, Rituximab adverse effects, Immunosuppression Therapy adverse effects, Lung Transplantation adverse effects, Lymphoproliferative Disorders virology
- Abstract
Post-transplantation lymphoproliferative disorder (PTLD) is uncommon following solid organ transplantation. We present a case of PTLD presenting as hematochezia and abdominal pain in a 66-year-old man, who had undergone bilateral lung transplantation with alemtuzumab induction 7 months prior to presentation. The transplant serologic status was "high-risk" for the presence of both Epstein-Barr virus (EBV) serologies in the donor and negative serologies in the recipient. Biopsies taken during colonoscopy stained strongly positive for EBV-encoded RNA. Mediastinal lymph node biopsies also showed atypical, EBV-positive lymphohistiocytic infiltration with focal necrosis. The patient's hospital course was complicated by treatment side effects, most notably bowel perforation following rituximab. In this case report the topic of PTLD is reviewed and consideration is given to whether alemtuzumab induction may have contributed to the patient's development of PTLD., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
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