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A 66-year-old woman presented with melena for 5 months with an episode of haematemesis. Ultrasonography revealed hepatosplenomegaly. Her complete blood count showed anaemia (haemoglobin of 44 g/L), hyperleucocytosis (total leucocyte count 323.99×109/L) and thrombocytopenia (platelets of 40×109/L

Castleman's disease represents an atypical lymphoproliferative disorder which is non-clonal but can turn malignant in the form of lymphoma, Kaposi's sarcoma or plasma cell dyscrasia. It has been reported in association with diseases like polyneuropathy organomegaly endocrinopathy monoclonal gammopathy skin changes syndrome and myeloma and very rarely it can be associated with cutaneous vasculitis as in our case. It relatively runs an aggressive course and has a shorter survival. No standard of care therapy is yet established for multicentric Castleman's disease accompanying myeloma. We successfully treated one such patient with bortezomib-based therapy.