13 results
Search Results
2. Controlled Comparison of Lymecycline with Tetracycline Hydrochloride in Exacerbations of Chronic Bronchitis
- Author
-
A. Pines, R. C. Mitchell, K. Plucinski, and J.S.B. Greenfield
- Subjects
medicine.medical_specialty ,Chronic bronchitis ,Biomedical Research ,Tetracycline ,medicine.drug_class ,Statistics as Topic ,Antibiotics ,Toxicology ,Gastroenterology ,Tetracycline Hydrochloride ,Lymecycline ,Internal medicine ,medicine ,Bronchitis ,General Environmental Science ,Bronchiectasis ,business.industry ,Sputum ,General Engineering ,Drug Tolerance ,Pneumonia ,Papers and Originals ,General Medicine ,Pneumonia, Pneumococcal ,medicine.disease ,Anti-Bacterial Agents ,Surgery ,Bronchitis, Chronic ,General Earth and Planetary Sciences ,medicine.symptom ,business ,medicine.drug - Published
- 1964
3. Pyogenic Infection of Liver Secondary to Infection in the Portal Drainage Area
- Author
-
C. G. McKenzie
- Subjects
medicine.medical_specialty ,Fever ,medicine.drug_class ,Liver Abscess ,Antibiotics ,Subphrenic abscess ,Portal vein ,Thrombophlebitis ,Diagnosis, Differential ,Pathology ,Humans ,Medicine ,General Environmental Science ,Subphrenic Abscess ,Suppuration ,Portal Vein ,business.industry ,General Engineering ,Papers and Originals ,General Medicine ,Alkaline Phosphatase ,medicine.disease ,Anti-Bacterial Agents ,Blood Cell Count ,Surgery ,Pyogenic infection ,Hemoglobinometry ,Drainage ,Prednisone ,General Earth and Planetary Sciences ,Differential diagnosis ,business ,Liver abscess - Published
- 1964
4. Colonic Perforation after Exchange Transfusion
- Author
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V. Dubowitz, J. J. Corkery, James Lister, and A. Moosa
- Subjects
Male ,Umbilical Veins ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Antibiotics ,Perforation (oil well) ,Exchange Transfusion, Whole Blood ,Rectum ,Exchange transfusion ,Blood Pressure ,Catheterization ,Erythroblastosis, Fetal ,Colonic Diseases ,Pregnancy ,Laparotomy ,medicine ,Humans ,General Environmental Science ,Portal Vein ,business.industry ,Infant, Newborn ,General Engineering ,Papers and Originals ,General Medicine ,Insidious onset ,Anti-Bacterial Agents ,Surgery ,Conservative treatment ,medicine.anatomical_structure ,Intestinal Perforation ,Anesthesia ,General Earth and Planetary Sciences ,Female ,Gastrointestinal Hemorrhage ,business ,Haemolytic disease - Abstract
Four patients are reported in whom perforation of the colon followed exchange transfusion for haemolytic disease of the newborn. This association seems to be more than coincidental, and possibly the perforation is due to a vascular accident occurring as a mechanical result of the exchange transfusion. The insidious onset of colonic perforation may be recognized early by the passage of blood per rectum. There is no place for conservative treatment, and once the diagnosis has been made treatment must include broad-spectrum antibiotics and laparotomy.
- Published
- 1968
5. Rejection Processes in Human Homotransplanted Kidneys
- Author
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W. J. Dempster, R. Shackman, and C. V. Harrison
- Subjects
Pathology ,medicine.medical_specialty ,Hydrocortisone ,Cyclophosphamide ,medicine.drug_class ,Statistics as Topic ,Antibiotics ,Kidney ,Glomerulonephritis ,Transplantation Immunology ,medicine ,Humans ,Transplantation, Homologous ,Vascular Diseases ,Kidney transplantation ,General Environmental Science ,Pyelonephritis ,business.industry ,General Engineering ,Papers and Originals ,General Medicine ,medicine.disease ,Kidney Transplantation ,Anti-Bacterial Agents ,General Earth and Planetary Sciences ,business ,medicine.drug - Published
- 1964
6. Painful Dysphagia Due to Monilial Oesophagitis
- Author
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Richard M. Buckle and W. D. Nichol
- Subjects
Nystatin ,medicine.medical_specialty ,medicine.drug_class ,Prednisolone ,Antibiotics ,Gastroenterology ,Candidiasis, Oral ,Internal medicine ,Diagnosis ,medicine ,Esophagitis ,Humans ,Colitis ,General Environmental Science ,Sulfonamides ,business.industry ,Candidiasis ,General Engineering ,Pneumonia ,Papers and Originals ,General Medicine ,Tetracycline ,medicine.disease ,Dysphagia ,Ulcerative colitis ,Anti-Bacterial Agents ,Surgery ,Radiography ,General Earth and Planetary Sciences ,medicine.symptom ,Deglutition Disorders ,business ,medicine.drug - Published
- 1964
7. Treatment of Bacillary Dysentery
- Author
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D. J. Stoker
- Subjects
medicine.drug_class ,Tetracycline ,Antibiotics ,Prevalence ,Bacillus ,Dysentery ,Microbiology ,Medicine ,Dysentery, Bacillary ,General Environmental Science ,Protein Synthesis Inhibitors ,business.industry ,Sulfadimidine ,Incidence (epidemiology) ,General Engineering ,Bacillary dysentery ,Papers and Originals ,General Medicine ,medicine.disease ,Anti-Bacterial Agents ,Lacticaseibacillus casei ,Streptomycin ,General Earth and Planetary Sciences ,business ,medicine.drug - Published
- 1962
8. Jaundice in Severe Infections
- Author
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A. Eley, T. Hargreaves, and H. P. Lambert
- Subjects
medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Subphrenic abscess ,Jaundice ,Infections ,Pelvis ,Diagnosis, Differential ,Pharmacotherapy ,Drug Therapy ,Liver Function Tests ,Streptococcal Infections ,Animals ,Humans ,Surgical Wound Infection ,Medicine ,Abscess ,Fallopian Tubes ,General Environmental Science ,Subphrenic Abscess ,Pyelonephritis ,medicine.diagnostic_test ,business.industry ,Ovary ,Proteus Infections ,General Engineering ,Papers and Originals ,General Medicine ,Appendicitis ,medicine.disease ,Dermatology ,Anti-Bacterial Agents ,Surgery ,Jaundice, Obstructive ,General Earth and Planetary Sciences ,Female ,medicine.symptom ,business ,Liver function tests - Published
- 1965
9. 'Colomycin'--Laboratory and Clinical Investigations
- Author
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Geoffrey Taylor and Howard Allison
- Subjects
Thorax ,Gram-negative bacteria ,medicine.drug_class ,Urinary system ,Gram-positive bacteria ,Antibiotics ,Varicose Ulcer ,Microbiology ,medicine ,Humans ,Pseudomonas Infections ,General Environmental Science ,biology ,General Engineering ,Papers and Originals ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,Surgical Procedures, Operative ,Urinary Tract Infections ,Toxicity ,Colistin ,General Earth and Planetary Sciences ,Laboratories ,Intramuscular injection ,medicine.drug - Published
- 1962
10. Transferable Drug Resistance in Enterobacteria Isolated from Urban Infants
- Author
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E. C. Moorhouse
- Subjects
Flora ,Urban Population ,medicine.drug_class ,Penicillin Resistance ,Antibiotics ,Drug resistance ,Biology ,Microbiology ,Feces ,Nalidixic Acid ,Pharmacotherapy ,Enterobacteriaceae ,Species Specificity ,Escherichia coli ,medicine ,Humans ,General Environmental Science ,Cross Infection ,Sulfonamides ,General Engineering ,Furazolidone ,Infant ,Neomycin ,Papers and Originals ,General Medicine ,Tetracycline ,Anti-Bacterial Agents ,Chloramphenicol ,Antibacterial therapy ,Streptomycin ,General Earth and Planetary Sciences ,Ampicillin - Abstract
Antibiotic-resistant enterobacteria, the vast majority of which carried transmissible R factors, were isolated from 81 out of a total of 100 healthy infants. There was surprisingly little correlation between previous antibacterial therapy and the resistant enterobacterial flora.
- Published
- 1969
11. Coincident Salmonella Infections and Ulcerative Colitis: Problems of Recognition and Management
- Author
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M. J. S. Langman, M. W. Dronfield, and J. Fletcher
- Subjects
Adult ,Male ,medicine.medical_specialty ,Salmonella ,medicine.drug_class ,Salmonella septicaemia ,Antibiotics ,medicine.disease_cause ,Gastroenterology ,Sepsis ,Systemic antibiotics ,Adrenal Cortex Hormones ,Internal medicine ,medicine ,Humans ,Colitis ,General Environmental Science ,business.industry ,General Engineering ,Papers and Originals ,General Medicine ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Anti-Bacterial Agents ,Radiography ,Drug Combinations ,Corticosteroid therapy ,Salmonella Infections ,Immunology ,General Earth and Planetary Sciences ,Colitis, Ulcerative ,Female ,business - Abstract
Five cases of coincident salmonellosis and ulcerative colitis are described. In three the diagnostic combination was recognized late. If corticosteroid therapy is given for the colitis once the combination is recognized, then simultaneous systemic antibiotic cover is advisable. One of the five patients died during corticosteroid therapy alone with salmonella septicaemia due to a usually non-invasive organism.
- Published
- 1974
12. Resistance of Haemophilus influenzae to Trimethoprim
- Author
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J R May and J Davies
- Subjects
Sulfamethoxazole ,medicine.drug_class ,Antibiotics ,Bronchi ,Microbial Sensitivity Tests ,Drug resistance ,Biology ,medicine.disease_cause ,Trimethoprim ,Haemophilus influenzae ,Microbiology ,medicine ,Humans ,Respiratory Tract Infections ,General Environmental Science ,Respiratory tract infections ,Sputum ,General Engineering ,Drug Resistance, Microbial ,Drug Synergism ,Papers and Originals ,General Medicine ,medicine.disease ,Anti-Bacterial Agents ,Drug Combinations ,Pyrimidines ,Chronic Disease ,Folic Acid Antagonists ,General Earth and Planetary Sciences ,Bronchitis ,medicine.symptom ,medicine.drug - Abstract
Out of 210 isolates of Haemophilus influenzae obtained from the sputum of 63 patients with chronic respiratory infections 109 (52%) were resistant to trimethoprim-sulphamethoxazole by the disc test. The minimal inhibitory concentrations of trimethoprim for 17 out of 18 strains recorded as resistant were 10 mug/ml or higher. Resistant strains were isolated from time to time from 32 (82%) out of 39 patients known to have been treated with trimethoprim-sulphamethoxazole, compared with only 1 (12.5%) out of 8 patients known not to have been treated with this drug combination. Resistant strains were isolated most frequently from patients who had received long-term treatment. Since sulphamethoxazole penetrates from the blood into the bronchial secretions less readily than does trimethoprim it seems likely that the ratio of the two drugs in the bronchial tree is far from ideal. This may be an important factor in the use of these drugs for chest infections.
- Published
- 1972
13. Laboratory Aspects of Combined Antibiotic Treatment
- Author
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Pamela Jewell, S. D. Elek, and G. R. F. Hilson
- Subjects
Chlortetracycline ,medicine.drug_class ,Antibiotics ,Penicillins ,Microbiology ,In vivo ,medicine ,Humans ,Agar diffusion test ,General Environmental Science ,business.industry ,Chloramphenicol ,General Engineering ,Articles ,General Medicine ,Anti-Bacterial Agents ,Penicillin ,Streptomycin ,General Earth and Planetary Sciences ,Laboratories ,Antagonism ,business ,medicine.drug - Abstract
Since Ungar's observation in 1943 that penicillin and sulphonamides enhance each other's action, the subject of synergism and antagonism between antibacterial sub stances has received much attention and has recently been extensively reviewed by Garrod (1953). Tests have been made both in vitro and in vivo, and it is certain that some interaction between antibiotics exists and is likely to be therapeutically important. Clinical experience, though limited, confirms this view; on the one hand, it appears that in the treatment of enterococcal endocarditis a combination of penicillin and streptomycin is more efficient than either drug alone (Hunter, 1950; Robbins and Tompsett, 1951 ; Cates et al., 1951), and, on the other hand, in pneumococcal meningitis, penicillin and aureomycin used together are less effective than penicillin alone (Lepper and Dowling, 1951). Interaction occurs in at least three of the manifesta tions of the antibiotic action: inhibition of growth, lethal effect, and emergence of resistant variants. Growth-inhibition tests are simple to perform, but when used to investigate the combined action of antibiotics often fail to correlate with findings in vivo (Jawetz, Gunnison, Speck, and Coleman, 1951; Chopra and Gupta, 1951 ; Bliss et al., 1952). The estimation of the bactericidal effect of a pair of drugs, as opposed to bac teriostatic effect, is much more laborious, but interaction shown in this way may have more therapeutic significance (Hunter, 1950; Gunnison, Jawetz, and Coleman, 1950; Garrod, 1953). The emergence of resistant variants is also bound up with bactericidal action. The present paper records an investigation -of the lethal action of com binations of antibiotics, using a technique simpler than those previously described. The terms synergism and antagonism are defined as follows: a combination of drugs is synergistic when its lethal effect is greater than that of the more lethal drug alone, and antagonistic when its effect is less. Synergism, defined in this way, includes the term " additive " described by other authors. There may, of course, be no interaction, in which case the effect of the more lethal drug is dominant. A number of different methods have been used in studying the bactericidal effects of mixtures of antibiotics. Generally, complete viable counts have been made at intervals on cultures containing several different con centrations of antibiotics. In order to carry out testing on a larger scale, some workers have used simplified viable counts (Bigger, 1944; Nichols, 1948; Rantz and Randall, 1952), and others the turbidimetric estimation of growth from surviving bacteria (Thomas and Hayes, 1947; Burnell and Kirby, 1951). All these methods are unsuitable for routine testing in a busy clinical labora tory. The simplified viable count method of Martin et al. (1952), recommended by Garrod (1953), tests the action of a pair of antibiotics at one concentration only. This is likely to be misleading, as there are reports that concentrations are important (Hobby and Dawson, 1946; Bliss et al., 1952). The conditions under which antibiotics act in the body are varied, and it is probable that when a patient receives two drugs their relative con centration fluctuates widely. Agar diffusion methods used to detect inhibitory levels have the great advantage of allowing a range of relative concentrations to be tested easily, and as they are also widely employed for routine sensitivity tests it is not surprising that attempts have been made to show interaction by such methods (Peyre and Velu, 1952; King et al., 1953 ; Garrod, 1953). These attempts have, however, been based on interactions at the inhibitory level, and we believe that the appearances of inhibition on solid media can give misleading information. A further step is required to show whether the growth one sees is alive or whether in fact it has been killed. The technique we have used is an agar diffusion method amplified by a simple form of sampling to reveal the l thal action of the antibiotics.
- Published
- 1953
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