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2 results on '"Mohammed, Shahait"'

1. Ki-67 expression predicts biochemical recurrence after radical prostatectomy in the setting of positive surgical margins

Author

Mohammed Shahait, Samer Nassif, Hani Tamim, Deborah Mukherji, Maya Hijazi, Marwan El Sabban, Raja Khauli, Muhammad Bulbul, Wassim Abou Kheir, and Albert El Hajj

Subjects
Ki-67, Positive surgical margin, Radical prostatectomy, Biochemical recurrence, Prostate cancer, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Positive surgical margin (PSM) is a predictor of biochemical recurrence (BCR) following radical prostatectomy (RP). Attempts to stratify PSM based on linear length, Gleason score, location and number have failed to add to predictive models using margin status alone. We evaluated the prognostic significance of Ki-67 expression in this setting. Methods Immunohistochemical staining for Ki-67 was done on prostatectomy specimens from 117 patients who had a PSM. Ki67 expression was measured at the margin and in the index lesion. Patients were dichotomized based on Ki-67 expression into three groups. Group 1 with no Ki-67 expression, Group 2 with Ki-67 ≤ 2%, and Group 3 with Ki-67 ≥ 3%. To eliminate the impact of the adjuvant treatment (AT) on the outcome, data were analyzed by the Cox proportional hazards in which AT was Considered as a time-dependent covariate. Results The discordance rate of Ki-67 expression between matched index lesion and margin specimens was 44/117 (37.6%). There was a trend for higher risk of BCR (HR:2.06, (0.97–4.43), P = 0.06) in patients expressing high Ki67 at the surgical margin although this was not statistically significant. However High Ki-67 expression in the index lesion was an independent predictive factor for BCR in this subset of patients. (HR:4, (1.64–9.80), P = 0.002). Conclusion High Ki67 expression in the index prostate cancer lesion is an independent predictor of BCR in patients with positive surgical margin following radical prostatectomy. Our findings need to be validated in a larger cohort.

Published
2018
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2. Preoperative lymphocyte-to-monocyte ratio predicts clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder: a retrospective analysis

Author

Maya Charafeddine, Mohammad Rachad Wehbe, Zein Farhat, Deborah Mukherji, Rami Nasr, Mohammed Shahait, Ali Shamseddine, Rami Abou Ghaida, Ibrahim Abu Gheida, and Sally Temraz

Subjects
Adult, Male, medicine.medical_specialty, Urinary bladder neoplasms, Urology, medicine.medical_treatment, Lymphocyte, Kaplan-Meier Estimate, Cystectomy, Gastroenterology, Monocytes, Leukocyte Count, Transitional cell carcinoma, Internal medicine, medicine, Carcinoma, Humans, Lymphocytes, Prospective cohort study, Aged, Retrospective Studies, Inflammation, Aged, 80 and over, Carcinoma, Transitional Cell, Bladder cancer, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, medicine.anatomical_structure, ROC Curve, Reproductive Medicine, Preoperative Period, Cohort, Female, Neoplasm Recurrence, Local, business, Research Article
Abstract

Background Inflammation is a critical component of tumorigenesis, and many cancers arise from sites of infection, chronic irritation, and inflammation. Inflammatory cytokines triggered by tumors alter hematologic components, including neutrophil, lymphocyte, and monocyte counts. The neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios have been shown to be valuable prognostic markers in various types of cancers, including bladder cancer. Risk stratification based on clinicopathologic data is insufficient to support treatment-related choices in patients with bladder cancer. Novel prognostic markers are therefore needed. An elevated pretreatment lymphocyte-to-monocyte ratio (LMR) is reportedly associated with improved overall survival (OS) and a longer time to treatment recurrence (TTR) in some types of cancers. However, these data are lacking in patients with bladder cancer. The aim of the present study was to investigate the effect of the preoperative LMR on OS and TTR in a cohort of patients with bladder cancer. Methods Sixty-eight patients with transitional cell carcinoma of the bladder were included in this retrospective analysis. The associations between a high and low LMR with OS and TTR were analyzed using Kaplan–Meier curves and compared by the log-rank test. Results In our study cohort, an elevated preoperative LMR was significantly associated with an increased TTR (P = 0.001) and OS (P = 0.020). Patients with an LMR of ≤2.87 showed a median TTR of 2.0 years (95% CI, 0.27–3.73), whereas patients with an LMR of >2.87 had a median TTR of 11.1 years (95% CI, 2.31–19.88) (P = 0.001). Patients with an LMR of ≤2.81 showed a median OS of 2.7 years (95% CI, 0.63–4.70), whereas patients with an LMR of >2.81 had a median OS of 6.0 years (95% CI, 3.60–8.40) (P = 0.020). The clinical stage at diagnosis was the only clinicopathologic feature associated with the LMR, while tumor invasion depth showed borderline significance. Conclusions The LMR is an easily measured and inexpensive prognostic marker that was significantly correlated with OS and TTR in the present retrospective analysis. However, because of the small sample size in this study, larger multicenter, prospective studies are needed.

Published
2014
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