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Your search keyword '"Crolla, R.M.P.H. (Rogier)"' showing total 2 results
Start Over Author "Crolla, R.M.P.H. (Rogier)" Journal bmc surgery vol. 10
2 results on '"Crolla, R.M.P.H. (Rogier)"'

1. The ladies trial: Laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Author

Swank, D.J. (Dingeman), Vermeulen, J. (Jefrey), Lange, J.F. (Johan), Mulder, I.M. (Irene), Hoeven, J.A.B. (Joost) van der, Stassen, L.P. (Laurents), Crolla, R.M.P.H. (Rogier), Sosef, M.N. (Meindert), Nienhuijs, S.W. (Simon), Bosker, R.J.I. (Robbert), Boom, M.J. (Maarten), Kruyt, Ph.M. (Philip), Steup, W.H. (Willem Hans), Graaf, E.J.R. (Eelco) de, Weidema, W.F. (Wibo), Pierik, R.E.G.J.M. (Robert), Prins, H.A. (Hubert), Stockmann, H.B.A.C., Tollenaar, R.A.E.M. (Rob), Wagensveld, B.A. (Bart) van, Coene, P-P. (Peter Paul), Slooter, G.D. (Gerrit), Consten, E.C. (Esther), Duijn, E.B. (Eino) van, Gerhards, M.F. (Michael), Hoofwijk, A.G.M. (Anton), Karsten, T.M. (Thomas), Neijenhuis, P.A. (Peter), Blanken-Peeters, C.F.J.M. (Charlotte), Cense, H.A. (Huib), Mannaerts, G.H.H. (Guido), Bruin, S.C. (Sjoerd), Eijsbouts, Q.A. (Quirijn), Wiezer, M.J. (Marinus), Hazebroek, E.J. (Eric Jasper), Geloven, A.A. (Anna) van, Maring, J.K. (John), D'Hoore, A. (André), Kartheuser, A. (Alex), Remue, C. (Christophe), Grevenstein, H.M.U. (Helma) van, Konsten, J.L.M. (Joop), Peet, D.L. (Donald) van der, Govaert, M.J.P.M. (Marc), Engel, A.F. (Alexander), Reitsma, J.B. (Johannes), Bemelman, W.A. (Willem), Swank, D.J. (Dingeman), Vermeulen, J. (Jefrey), Lange, J.F. (Johan), Mulder, I.M. (Irene), Hoeven, J.A.B. (Joost) van der, Stassen, L.P. (Laurents), Crolla, R.M.P.H. (Rogier), Sosef, M.N. (Meindert), Nienhuijs, S.W. (Simon), Bosker, R.J.I. (Robbert), Boom, M.J. (Maarten), Kruyt, Ph.M. (Philip), Steup, W.H. (Willem Hans), Graaf, E.J.R. (Eelco) de, Weidema, W.F. (Wibo), Pierik, R.E.G.J.M. (Robert), Prins, H.A. (Hubert), Stockmann, H.B.A.C., Tollenaar, R.A.E.M. (Rob), Wagensveld, B.A. (Bart) van, Coene, P-P. (Peter Paul), Slooter, G.D. (Gerrit), Consten, E.C. (Esther), Duijn, E.B. (Eino) van, Gerhards, M.F. (Michael), Hoofwijk, A.G.M. (Anton), Karsten, T.M. (Thomas), Neijenhuis, P.A. (Peter), Blanken-Peeters, C.F.J.M. (Charlotte), Cense, H.A. (Huib), Mannaerts, G.H.H. (Guido), Bruin, S.C. (Sjoerd), Eijsbouts, Q.A. (Quirijn), Wiezer, M.J. (Marinus), Hazebroek, E.J. (Eric Jasper), Geloven, A.A. (Anna) van, Maring, J.K. (John), D'Hoore, A. (André), Kartheuser, A. (Alex), Remue, C. (Christophe), Grevenstein, H.M.U. (Helma) van, Konsten, J.L.M. (Joop), Peet, D.L. (Donald) van der, Govaert, M.J.P.M. (Marc), Engel, A.F. (Alexander), Reitsma, J.B. (Johannes), and Bemelman, W.A. (Willem)

Abstract

Background: Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis). Methods/Design: In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and power

Published
2010
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2. Direct trial. Diverticulitis recurrences or continuing symptoms: Operative versus conservative Treatment. A Multicenter randomised clinical trial

Author

Wall, B.J.M. (Bryan) van de, Draaisma, W.A. (Werner), Consten, E.C. (Esther), Graaf, Y. (Yolanda) van der, Otten, M.H. (Marten Henk), Wit, G.A. (Ardine) de, Stel, H.F. (Henk) van, Gerhards, M.F. (Michael), Wiezer, M.J. (Marinus), Cense, H.A. (Huib), Stockmann, H.B.A.C. (Hein), Leijtens, J.W.A. (Jeroen), Zimmerman, D.D.E. (David), Belgers, E.H.J. (Eric), Wagensveld, B.A. (Bart) van, Sonneveld, E.D.J.A. (Eric), Prins, H.A. (Hubert), Coene, P-P. (Peter Paul), Karsten, T.M. (Thomas), Klaase, J.M. (Joost), Statius Muller, M.G. (Markwin), Crolla, R.M.P.H. (Rogier), Broeders, I.A.M.J. (Ivo), Wall, B.J.M. (Bryan) van de, Draaisma, W.A. (Werner), Consten, E.C. (Esther), Graaf, Y. (Yolanda) van der, Otten, M.H. (Marten Henk), Wit, G.A. (Ardine) de, Stel, H.F. (Henk) van, Gerhards, M.F. (Michael), Wiezer, M.J. (Marinus), Cense, H.A. (Huib), Stockmann, H.B.A.C. (Hein), Leijtens, J.W.A. (Jeroen), Zimmerman, D.D.E. (David), Belgers, E.H.J. (Eric), Wagensveld, B.A. (Bart) van, Sonneveld, E.D.J.A. (Eric), Prins, H.A. (Hubert), Coene, P-P. (Peter Paul), Karsten, T.M. (Thomas), Klaase, J.M. (Joost), Statius Muller, M.G. (Markwin), Crolla, R.M.P.H. (Rogier), and Broeders, I.A.M.J. (Ivo)

Abstract

Background: Persisting abdominal complaints are common after an episode of diverticulitis treated conservatively. Furthermore, some patients develop frequent recurrences. These two groups of patients suffer greatly from their disease, as shown by impaired health related quality of life and increased costs due to multiple specialist consultations, pain medication and productivity losses. Both conservative and operative management of patients with persisting abdominal complaints after an episode of diverticulitis and/or frequently recurring diverticulitis are applied. However, direct comparison by a randomised controlled trial is necessary to determine which is superior in relieving symptoms, optimising health related quality of life, minimising costs and preventing diverticulitis recurrences against acceptable morbidity and mortality associated with surgery or the occurrence of a complicated recurrence after conservative management. We, therefore, constructed a randomised clinical trial comparing these two treatment strategies. Methods/design: The DIRECT trial is a multicenter randomised clinical trial. Patients (18-75 years) presenting themselves with persisting abdominal complaints after an episode of diverticulitis and/or three or more recurrences within 2 years will be included and randomised. Patients randomised for conservative treatment are treated according to the current daily practice (antibiotics, analgetics and/or expectant management). Patients randomised for elective resection will undergo an elective resection of the affected colon segment. Preferably, a laparoscopic approach is used. The primary outcome is health related quality of life measured by the Gastro-intestinal Quality of Life Index, Short-Form 36, EQ-5D and a visual analogue scale for pain quantification. Secondary endpoints are morbidity, mortality and total costs. The total follow-up

Published
2010
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