1. The first Malay database toward the ethnic-specific target molecular variation
- Author
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Rosnah Binti Zain, Atif Amin Baig, Surini Yusoff, Ab Rajab Nur-Shafawati, Bin Alwi Zilfalil, Noor Haslina Mohd Noor, Shafini Mohamed Yusoff, Amir Feisal Merican, Rosnah Bahar, Azlina Ahmad Annuar, Hatin Wan-Isa, Marini Ramli, Zarina Abdul Latiff, Iman Salahshourifar, Zahurin Mohamed, Meow-Keong Thong, Noraishah Mydin Abdul-Aziz, Ahmad Tajudin Liza-Sharmini, Ahmad Zubaidi A. Latif, Mohamed Irwan Shah, Wan Zaidah Abdullah, Endom Ismail, Muhammad Farid Johan, Hashim Halim-Fikri, Ali Etemad, Soon Guan Tan, Rosline Hassan, and Nik Norliza Nik Hassan
- Subjects
Population ,Ethnic group ,Human Variome Project ,Genomics ,Single-nucleotide polymorphism ,computer.software_genre ,Data Note ,General Biochemistry, Genetics and Molecular Biology ,Genetic variation ,parasitic diseases ,Databases, Genetic ,Ethnicity ,Medicine ,Humans ,Copy-number variation ,education ,Malay ,Medicine(all) ,CNVs ,education.field_of_study ,Database ,Biochemistry, Genetics and Molecular Biology(all) ,business.industry ,Malaysia ,General Medicine ,language.human_language ,Ethnic-specific molecular variation database ,language ,Disease genes and their products ,Malaysian Node of the Human Variome Project ,business ,computer ,SNPs - Abstract
The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9th October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb). Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ). This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.
- Published
- 2015