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Your search keyword '"Early onset preeclampsia"' showing total 3 results
Start Over Descriptor "Early onset preeclampsia" Journal bmc research notes
3 results on '"Early onset preeclampsia"'

1. Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia

Author

W. Permadi, K. I. Mantilidewi, A. F. Khairani, U. A. Lantika, A. R. Ronosulistyo, and H. Bayuaji

Subjects
PPAR-γ, Early onset preeclampsia, Late-onset preeclampsia, Trophoblast, Placenta, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Objective PPARγ is a ligand-binding transcription factor that has been reported to be implicated in lipid metabolism, immune function, and cellular growth and differentiation. It has been suspected to play a role in the pathophysiology of preeclampsia, although the mechanism is yet to be elaborated. This study aims to investigate the expression of PPARγ in early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normal pregnancy. We conducted this study using primary trophoblastic cell culture incubated with serum from EOPE, LOPE, and normal pregnancy. The expression of PPARγ in these cells was analyzed using Western Blot. Statistical analysis was performed using one-way ANOVA and Bonferroni’s post hoc test. p 0.05). In contrast, expression of PPAR-γ was increased in those cells induced by serum from LOPE (p

Published
2020
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2. Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia.

Author

Permadi, W., Mantilidewi, K. I., Khairani, A. F., Lantika, U. A., Ronosulistyo, A. R., and Bayuaji, H.

Subjects
*PREECLAMPSIA, *PREGNANT women, *CELL growth, *ONE-way analysis of variance, *CELL culture, *LIPID metabolism, *NUCLEAR receptors (Biochemistry)
Abstract

Objective: PPARγ is a ligand-binding transcription factor that has been reported to be implicated in lipid metabolism, immune function, and cellular growth and differentiation. It has been suspected to play a role in the pathophysiology of preeclampsia, although the mechanism is yet to be elaborated. This study aims to investigate the expression of PPARγ in early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normal pregnancy. We conducted this study using primary trophoblastic cell culture incubated with serum from EOPE, LOPE, and normal pregnancy. The expression of PPARγ in these cells was analyzed using Western Blot. Statistical analysis was performed using one-way ANOVA and Bonferroni's post hoc test. p < 0.05 is considered significant. Results: Serum from normal pregnant women and EOPE did not induce any difference in the expression of PPAR-γ (p > 0.05). In contrast, expression of PPAR-γ was increased in those cells induced by serum from LOPE (p < 0.001). Therefore, we conclude that hypothetically PPAR-γ might play role in the pathophysiology of LOPE but not in EOPE. Other possibility is the activity of PPAR-γ in EOPE is inversely correlated with its expression, therefore the high enzymatic activity of PPAR-γ is tightly regulated by attenuating its expression. [ABSTRACT FROM AUTHOR]

Published
2020
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3. Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia

Author

Uci Ary Lantika, Kemala Isnainiasih Mantilidewi, Wiryawan Permadi, Astrid Feinisa Khairani, A. R. Ronosulistyo, and Hartanto Bayuaji

Subjects
medicine.medical_specialty, PPAR-γ, Placenta, lcsh:Medicine, Peroxisome proliferator-activated receptor, 030204 cardiovascular system & hematology, General Biochemistry, Genetics and Molecular Biology, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Western blot, Pre-Eclampsia, Pregnancy, Internal medicine, medicine, Humans, Age of Onset, lcsh:Science (General), lcsh:QH301-705.5, Transcription factor, chemistry.chemical_classification, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, business.industry, lcsh:R, Trophoblast, Lipid metabolism, General Medicine, medicine.disease, Pathophysiology, Trophoblasts, PPAR gamma, Research Note, Endocrinology, medicine.anatomical_structure, lcsh:Biology (General), chemistry, Female, Late-onset preeclampsia, business, Early onset preeclampsia, lcsh:Q1-390
Abstract

Objective PPARγ is a ligand-binding transcription factor that has been reported to be implicated in lipid metabolism, immune function, and cellular growth and differentiation. It has been suspected to play a role in the pathophysiology of preeclampsia, although the mechanism is yet to be elaborated. This study aims to investigate the expression of PPARγ in early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normal pregnancy. We conducted this study using primary trophoblastic cell culture incubated with serum from EOPE, LOPE, and normal pregnancy. The expression of PPARγ in these cells was analyzed using Western Blot. Statistical analysis was performed using one-way ANOVA and Bonferroni’s post hoc test. p Results Serum from normal pregnant women and EOPE did not induce any difference in the expression of PPAR-γ (p > 0.05). In contrast, expression of PPAR-γ was increased in those cells induced by serum from LOPE (p

Published
2020

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