1. Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
- Author
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Ping An, Mary F. Feitosa, Ingrid B. Borecki, Shamika Ketkar, Michael A. Province, Shiow Lin, and Avril Adelman
- Subjects
Oncology ,medicine.medical_specialty ,endocrine system ,endocrine system diseases ,Offspring ,Type 2 diabetes ,Bioinformatics ,Logistic regression ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Framingham Heart Study ,Polymorphism (computer science) ,Internal medicine ,medicine ,SNP ,030304 developmental biology ,0303 health sciences ,business.industry ,nutritional and metabolic diseases ,General Medicine ,medicine.disease ,Proceedings ,030220 oncology & carcinogenesis ,Cohort ,business ,TCF7L2 - Abstract
Fifteen known type 2 diabetes (T2D) gene variants were assessed for their associations with T2D status in 228 T2D families from the Framingham Heart Study (FHS) Original, Offspring, and Children Cohorts. Bayesian approach was used to test single-single-nucleotide polymorphism (SNP) association followed by logistic regression. Bayesian and logic regression approaches were used to test multiple SNP association searching for the best combinations of variants followed by logistic regression reconfirmation. The significant variants for T2D risk were also tested for their main and interacting effects on triglyceride (TG)/high-density lipoprotein (HDL) ratio change derived from four point measures across time. This slope phenotype was made available using mixed model growth curve approach from 155 T2D families in the FHS Offspring Cohort. Results CDKN2B rs10811661 (p = 0.042), TCF7L2 rs4506565 (p = 0.004), and JAZF1 rs864745 (p = 0.04) were individually associated with risk of T2D (OR = 1.0-2.0; effect size
- Published
- 2009