1. Development and post-Kasai procedure prognostic relevance of histological features for biliary atresia
- Author
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Xiaodan Xu, Xueting Wang, Meiyun Ding, Yilin Zhao, Li Zhao, Linsheng Zhao, Mengdi Li, Fangyuan Zhao, Rongjuan Sun, Zhiru Wang, Ruifeng Zhang, Shujian Zhang, Liang Ge, Yan Sun, and Jianghua Zhan
- Subjects
Biliary atresia ,Kasai procedure ,Liver fibrosis ,Staging system ,Prognosis ,Pediatrics ,RJ1-570 - Abstract
Abstract Objectives To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features of biliary atresia (BA) that could well predict its prognosis. Methods A total of 68 patients with BA who underwent Kasai procedure (KP) and an intraoperative liver biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, and BA-specific staging systems in relation to outcomes were analyzed using logistic regression, COX proportional hazard regression, Kaplan-Meier analysis, etc. Results Kaplan-Meier analysis determined a significant difference in native liver survival according to the BA-specific stage (p = 0.002). The ROC curve analysis for predicting prognosis showed that the AUC of BA-specific staging combined with iBALF and severe bile duct proliferation (BDP) (0.811, 95% CI: 0.710–0.913, p
- Published
- 2023
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