1. Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury
- Author
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Rae L. Russell, Gwendolyn J. Levine, C. Jane Welsh, Armando Mondragon, C. Elizabeth Boudreau, Colin R. Young, Nick D. Jeffery, Jonathan M. Levine, and Bryan Lee
- Subjects
Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Prostaglandin E2 ,Enzyme-Linked Immunosorbent Assay ,Severity of Illness Index ,Dinoprostone ,Thoracic Vertebrae ,Canine ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Dogs ,0302 clinical medicine ,Cerebrospinal fluid ,Phospholipase A2 ,Animals ,Medicine ,Dog Diseases ,Spinal cord injury ,Spinal Cord Injuries ,Arachidonic Acid ,Lumbar Vertebrae ,biology ,business.industry ,General Neuroscience ,Intervertebral disc ,medicine.disease ,Leukotriene C4 ,Phospholipases A2 ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Intervertebral Disc Displacement ,Thoracic vertebrae ,Linear Models ,biology.protein ,Female ,Arachidonic acid ,business ,Neurotrauma ,Biomarkers ,030217 neurology & neurosurgery ,Research Article ,medicine.drug - Abstract
Background Canine intervertebral disc πherniation causes a naturally-occurring spinal cord injury (SCI) that bears critical similarities to human SCI with respect to both injury pathomechanisms and treatment. As such, it has tremendous potential to enhance our understanding of injury biology and the preclinical evaluation of novel therapies. Currently, there is limited understanding of the role of arachidonic acid metabolites in canine SCI. Results The CSF concentrations of PLA2 and PGE2 were higher in SCI dogs compared to control dogs (p = 0.0370 and 0.0273, respectively), but CSF LCT4 concentration in SCI dogs was significantly lower than that in control dogs (p
- Published
- 2016
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