1. Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses
- Author
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Rémy Morello, Guillaume Lamotte, Denis Agostini, Adrien Lebasnier, Gilles Defer, Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité de Biostatistique et de Recherche Clinique (UBRC), Service de médecine nucléaire [CHU Caen], Sérine protéases et physiopathologie de l'unité neurovasculaire, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Bodescot, Myriam
- Subjects
Male ,Pathology ,Parkinson's disease ,Sympathetic innervation ,Single-photon emission computed tomography ,Scintigraphy ,Diagnosis ,Cutoff ,parkinsonism ,education.field_of_study ,medicine.diagnostic_test ,Mediastinum ,Brain ,Heart ,Parkinson Disease ,General Medicine ,Middle Aged ,3. Good health ,3-Iodobenzylguanidine ,medicine.anatomical_structure ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Lewy body dementia ,Research Article ,Lewy Body Disease ,medicine.medical_specialty ,Population ,Clinical Neurology ,Sensitivity and Specificity ,Parkinsonian Disorders ,medicine ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,education ,MIBG ,Aged ,Retrospective Studies ,Tomography, Emission-Computed, Single-Photon ,Lewy body ,Receiver operating characteristic ,business.industry ,Myocardium ,Reproducibility of Results ,medicine.disease ,ROC Curve ,Neurology (clinical) ,Radiopharmaceuticals ,business ,Nuclear medicine - Abstract
International audience; BACKGROUND: Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes.METHODS: We performed a monocentric retrospective analysis on 62 consecutive parkinsonian patients who underwent an (123)I-MIBG scintigraphy, brain imaging and dopaminergic imaging using (123)I-Ioflupane single photon emission computed tomography (SPECT) from 2009 to 2013. The optimal d-H/M ratio was determined from a Receiver Operating Characteristic (ROC) curve and the sensitivity (Se), specificity (Sp) and likelihood ratios (LR) were calculated. 42 patients were diagnosed with LB diseases (20 PD, 22 LBD) and 20 patients with other diseases.RESULTS: (123)I-MIBG scintigraphy helped to distinguish PD (p
- Published
- 2014