1. The weak correlation between serum vitamin levels and chronic kidney disease in hospitalized patients: a cross-sectional study
- Author
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Yong Wang, Ying Zheng, Pu Chen, Shuang Liang, Pengfei He, Xiaolei Shao, Guangyan Cai, and Xiangmei Chen
- Subjects
Chronic kidney disease ,Glomerular filtration rate ,Vitamin ,Deficiency ,Cross-sectional study ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Chronic kidney disease (CKD) has become a global public health problem. Accumulating evidence suggested that vitamins play important roles in the progression of CKD. Methods A cross-sectional study was conducted to investigate the vitamin status of patients with CKD at stage 1–5. The serum concentrations of 9 vitamins, vitamin A, B1, B2, B6, B9, B12, C, D, and E were measured by electroanalytical method with a Multi-Vitamin Analyzer. Pearson correlation and multiple linear regression between serum level of vitamins were analyzed. Results The median levels of vitamin A, B1, B2, B6, B9, B12, C and E were within the reference ranges or on the borderline. Vitamin D deficiency was found in all patients. Weak correlation was found between vitamin A or vitamin D and estimated glomerular filtration rate (eGFR). The Pearson correlation coefficient were − 0.21766 and 0.19752, respectively. Hypertension, diabetes mellitus, and atherosclerosis were the major comorbidities. Conclusions For the first time, the serum levels of 9 vitamins were measured simultaneously in patients with CKD at different stages. Vitamin D deficiency was found in all patients. Weak correlation between vitamin A or vitamin D and eGFR was found.
- Published
- 2021
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