1. Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
- Author
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Jieshan Lin, Bin Tang, Wenxue Hu, Wenke Hao, and Zhanwu Feng
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Intima-media thickness ,Lymphocyte ,B-Lymphocyte Subsets ,Renal function ,chemical and pharmacologic phenomena ,Risk Assessment ,Severity of Illness Index ,Gastroenterology ,chemistry.chemical_compound ,Elderly ,immune system diseases ,Chronic kidney disease ,hemic and lymphatic diseases ,Internal medicine ,Diabetes mellitus ,Humans ,Medicine ,Lymphocyte Count ,Renal Insufficiency, Chronic ,B cell ,Aged ,Retrospective Studies ,Aged, 80 and over ,B cells ,Creatinine ,business.industry ,Research ,Age Factors ,hemic and immune systems ,Atherosclerosis ,Prognosis ,medicine.disease ,Diseases of the genitourinary system. Urology ,medicine.anatomical_structure ,chemistry ,Female ,RC870-923 ,business ,Kidney disease - Abstract
Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by intima-media thickness, IMT) and prognosis in elderly patients with moderate-to-severe CKD. Methods In this study, a total of 219 patients (143 moderate-to-severe CKD patients with stage 3–4 and 76 non-CKD controls) were recruited. B cell subsets: CD19(+)CD5(+) and CD19(+)CD5(−) B cells were analyzed by flow cytometry. Intima-media thickness (IMT) was measured by ultrasound. Correlations between the B cell subsets with IMT and clinical outcome was analyzed. Results CKD patients showed increased IMT (P = 0.006). The level of CD19(+)CD5(+) and CD19(+)CD5(−) B cells were decreased in CKD patients. Correlation analysis showed that IMT was positively correlated with systolic blood pressure, protein/creatinine ratio and diabetes (P P P 9 /L) and CD19(+)CD5(−) B cells (≤ 0.05 × 109 /L) (P P P Conclusions Our results showed that decreased CD19(+)CD5(+) and CD19(+)CD5(−) B lymphocytes were correlated with atherosclerosis and worse survival, which indicates that B lymphocytes might involve in atherosclerosis and associated the prognosis of elderly patients with moderate-to-severe CKD.
- Published
- 2021