13 results on '"Severi, Gianluca"'
Search Results
2. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
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Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian
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- 2022
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3. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
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Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
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- 2022
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4. Use of systemic glucocorticoids and risk of breast cancer in a prospective cohort of postmenopausal women
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Cairat, Manon, Al Rahmoun, Marie, Gunter, Marc J., Heudel, Pierre-Etienne, Severi, Gianluca, Dossus, Laure, and Fournier, Agnès
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- 2021
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5. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort
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His, Mathilde, Viallon, Vivian, Dossus, Laure, Schmidt, Julie A., Travis, Ruth C., Gunter, Marc J., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Lécuyer, Lucie, Rothwell, Joseph A., Severi, Gianluca, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Macciotta, Alessandra, Boer, Jolanda M. A., Monninkhof, Evelyn M., Olsen, Karina Standahl, Nøst, Therese H., Sandanger, Torkjel M., Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Vidman, Linda, Winkvist, Anna, Heath, Alicia K., Weiderpass, Elisabete, Huybrechts, Inge, and Rinaldi, Sabina
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- 2021
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6. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
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Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, and Gunter, Marc J.
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- 2021
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7. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
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Seyed Khoei, Nazlisadat, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras-Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno-de-Mesquita, Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet, Catalina, Rodríguez-Barranco, Miguel, Gil, Leire, Chirlaque, Maria-Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Perez-Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín, Vicente, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, and Freisling, Heinz
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- 2020
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8. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
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- 2020
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9. Prospective analysis of circulating metabolites and breast cancer in EPIC
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His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina
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- 2019
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10. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
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Khoei, Nazlisadat Seyed, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno de Mesquita, H. Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet Bonet, Catalina, Rodríguez Barranco, Miguel, Gil, Leire, Chirlaque, María Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Pérez Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Marchand, Loïc Le, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín Sánchez, Vicente, Moreno Aguado, Víctor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, Freisling, Heinz, Apollo - University of Cambridge Repository, and Pharoah, Paul [0000-0001-8494-732X]
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Adult ,Male ,Nutrition and Disease ,Mendelian randomization analysis ,lcsh:Medicine ,Polymorphism, Single Nucleotide ,Antioxidants ,Càncer colorectal ,Risk Factors ,Voeding en Ziekte ,Humans ,Prospective Studies ,VLAG ,Cancer ,Aged ,lcsh:R ,Bilirubin ,Middle Aged ,Colorectal cancer ,Europe ,Case-Control Studies ,Anti-oxidants ,Female ,Colorectal Neoplasms ,Research Article - Abstract
Background: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex. Methods: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10−8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study. Results: The associations between circulating UCB levels and CRC risk differed by sex (Pheterogeneity = 0.008). Among men, higher levels of UCB were positively associated with CRC risk (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.04–1.36; per 1-SD increment of log-UCB). In women, an inverse association was observed (OR = 0.86 (0.76–0.97)). In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02–1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96–1.06); P = 0.73). Raised bilirubin levels, predicted by instrumental variables excluding rs6431625, were suggestive of an inverse association with CRC in men, but not in women. These differences by sex did not reach formal statistical significance (Pheterogeneity ≥ 0.2). Conclusions: Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.
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- 2020
11. Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort.
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Deschasaux-Tanguy, Mélanie, Srour, Bernard, Bourhis, Laurent, Arnault, Nathalie, Druesne-Pecollo, Nathalie, Esseddik, Younes, de Edelenyi, Fabien Szabo, Allègre, Julien, Allès, Benjamin, Andreeva, Valentina A., Baudry, Julia, Fezeu, Leopold K., Galan, Pilar, Julia, Chantal, Kesse-Guyot, Emmanuelle, Péneau, Sandrine, Hercberg, Serge, Bajos, Nathalie, Severi, Gianluca, and Zins, Marie
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SARS-CoV-2 ,DIETARY calcium ,FOOD consumption ,FOOD diaries ,COVID-19 ,NON-communicable diseases - Abstract
Background: Nutritional factors are essential for the functioning of the immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study the associations between diet and the risk of SARS-CoV-2 infection in a large population-based sample. Methods: Our analyses were conducted in the French prospective NutriNet-Santé cohort study (2009--2020). Seroprevalence of anti-SARS-CoV-2 antibodies was assessed by ELISA on dried blood spots. Dietary intakes were derived from repeated 24 h dietary records (at least 6) in the two years preceding the start of the COVID-19 pandemic in France (February 2020). Multi-adjusted logistic regression models were computed. Results: A total of 7766 adults (70.3% women, mean age: 60.3 years) were included, among which 311 were positive for anti-SARS-CoV-2 antibodies. Dietary intakes of vitamin C (OR for 1 SD=0.86 (0.75--0.98), P=0.02), vitamin B9 (OR=0.84 (0.72--0.98), P=0.02), vitamin K (OR=0.86 (0.74--0.99), P=0.04), fibers (OR=0.84 (0.72--0.98), P=0.02), and fruit and vegetables (OR=0.85 (0.74--0.97), P=0.02) were associated to a decreased probability of SARS-CoV-2 infection while dietary intakes of calcium (OR=1.16 (1.01--1.35), P=0.04) and dairy products (OR=1.19 (1.06--1.33), P=0.002) associated to increased odds. No association was detected with other food groups or nutrients or with the overall diet quality. Conclusions: Higher dietary intakes of fruit and vegetables and, consistently, of vitamin C, folate, vitamin K and fibers were associated with a lower susceptibility to SARS-CoV-2 infection. Beyond its established role in the prevention of non-communicable diseases, diet could therefore also contribute to prevent some infectious diseases such as COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
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Fedirko, Veronika, primary, Tran, Hao Quang, additional, Gewirtz, Andrew T., additional, Stepien, Magdalena, additional, Trichopoulou, Antonia, additional, Aleksandrova, Krasimira, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Carbonnel, Franck, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. B., additional, Weiderpass, Elisabete, additional, Castaño, José María Huerta, additional, Barricarte, Aurelio, additional, Sánchez, María-José, additional, Dorronsoro, Miren, additional, Quirós, J. Ramón, additional, Agudo, Antonio, additional, Sjöberg, Klas, additional, Ohlsson, Bodil, additional, Hemmingsson, Oskar, additional, Werner, Mårten, additional, Bradbury, Kathryn E., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Tsilidis, Konstantinos K., additional, Aune, Dagfinn, additional, Scalbert, Augustin, additional, Romieu, Isabelle, additional, Riboli, Elio, additional, and Jenab, Mazda, additional
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- 2017
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13. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
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Fages, Anne, primary, Duarte-Salles, Talita, additional, Stepien, Magdalena, additional, Ferrari, Pietro, additional, Fedirko, Veronika, additional, Pontoizeau, Clément, additional, Trichopoulou, Antonia, additional, Aleksandrova, Krasimira, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Kuhn, Tilman, additional, Floegel, Anna, additional, Boeing, Heiner, additional, Lagiou, Pagona, additional, Bamia, Christina, additional, Trichopoulos, Dimitrios, additional, Palli, Domenico, additional, Pala, Valeria, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Weiderpass, Elisabete, additional, Agudo, Antonio, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Sjöberg, Klas, additional, Ohlsson, Bodil, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Travis, Ruth C., additional, Schmidt, Julie A., additional, Cross, Amanda, additional, Gunter, Marc, additional, Riboli, Elio, additional, Scalbert, Augustin, additional, Romieu, Isabelle, additional, Elena-Herrmann, Benedicte, additional, and Jenab, Mazda, additional
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- 2015
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