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Your search keyword '"Dondorp, Arjen"' showing total 9 results
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9 results on '"Dondorp, Arjen"'

2. Mapping the travel patterns of people with malaria in Bangladesh

Author

Sinha, Ipsita, Sayeed, Abdullah Abu, Uddin, Didar, Wesolowski, Amy, Zaman, Sazid Ibna, Faiz, M. Abul, Ghose, Aniruddha, Rahman, M. Ridwanur, Islam, Akramul, Karim, Mohammad Jahirul, Saha, Anjan, Rezwan, M. Kamar, Shamsuzzaman, Abul Khair Mohammad, Jhora, Sanya Tahmina, Aktaruzzaman, M. M., Chang, Hsiao-Han, Miotto, Olivo, Kwiatkowski, Dominic, Dondorp, Arjen M., Day, Nicholas P. J., Hossain, M. Amir, Buckee, Caroline, and Maude, Richard J.

Published
2020
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3. Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Author

McLean, Alistair R. D., primary, Wai, Hla Phyo, additional, Thu, Aung Myat, additional, Khant, Zay Soe, additional, Indrasuta, Chanida, additional, Ashley, Elizabeth A., additional, Kyaw, Thar Tun, additional, Day, Nicholas P. J., additional, Dondorp, Arjen, additional, White, Nicholas J., additional, and Smithuis, Frank M., additional

Published
2018
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4. Erratum to: An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

Author

Leang, Rithea, primary, Khu, Naw Htee, additional, Mukaka, Mavuto, additional, Debackere, Mark, additional, Tripura, Rupam, additional, Kheang, Soy Ty, additional, Chy, Say, additional, Kak, Neeraj, additional, Buchy, Philippe, additional, Tarantola, Arnaud, additional, Menard, Didier, additional, Roca-Felterer, Arantxa, additional, Fairhurst, Rick M., additional, Kheng, Sim, additional, Muth, Sinoun, additional, Ngak, Song, additional, Dondorp, Arjen M., additional, White, Nicholas J., additional, and Taylor, Walter Robert John, additional

Published
2016
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5. An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

Author

Leang, Rithea, primary, Khu, Naw Htee, additional, Mukaka, Mavuto, additional, Debackere, Mark, additional, Tripura, Rupam, additional, Kheang, Soy Ty, additional, Chy, Say, additional, Kak, Neeraj, additional, Buchy, Philippe, additional, Tarantola, Arnaud, additional, Menard, Didier, additional, Roca-Felterer, Arantxa, additional, Fairhurst, Rick M., additional, Kheng, Sim, additional, Muth, Sinoun, additional, Ngak, Song, additional, Dondorp, Arjen M., additional, White, Nicholas J., additional, and Taylor, Walter Robert John, additional

Published
2016
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6. Malaria eradication and elimination: views on how to translate a vision into reality

Author

Tanner, Marcel, primary, Greenwood, Brian, additional, Whitty, Christopher J. M., additional, Ansah, Evelyn K., additional, Price, Ric N., additional, Dondorp, Arjen M., additional, von Seidlein, Lorenz, additional, Baird, J. Kevin, additional, Beeson, James G., additional, Fowkes, Freya J.I., additional, Hemingway, Janet, additional, Marsh, Kevin, additional, and Osier, Faith, additional

Published
2015
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7. Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study

Author

Hanson, Josh, primary, Lee, Sue J., additional, Hossain, Md Amir, additional, Anstey, Nicholas M., additional, Charunwatthana, Prakaykaew, additional, Maude, Richard J., additional, Kingston, Hugh W. F., additional, Mishra, Saroj K., additional, Mohanty, Sanjib, additional, Plewes, Katherine, additional, Piera, Kim, additional, Hassan, Mahtab U., additional, Ghose, Aniruddha, additional, Faiz, M. Abul, additional, White, Nicholas J., additional, Day, Nicholas P. J., additional, and Dondorp, Arjen M., additional

Published
2015
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8. The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis

Author

Hanson, Josh, primary, Phu, Nguyen Hoan, additional, Hasan, Mahtab Uddin, additional, Charunwatthana, Prakaykaew, additional, Plewes, Katherine, additional, Maude, Richard J, additional, Prapansilp, Panote, additional, Kingston, Hugh WF, additional, Mishra, Saroj K, additional, Mohanty, Sanjib, additional, Price, Ric N, additional, Faiz, M Abul, additional, Dondorp, Arjen M, additional, White, Nicholas J, additional, Hien, Tran Tinh, additional, and Day, Nicholas PJ, additional

Published
2015
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9. Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Author

Abdulla, Salim, Achan, Jane, Adam, Ishag, Alemayehu, Bereket H, Allan, Richard, Allen, Elizabeth N, Ankivar, Anupkumar R, Arinaitwe, Emmanuel, Ashley, Elizabeth A, Asih, Puji Budi Setia, Awab, Ghulam Rahib, Barnes, Karen I, Bassat, Quique, Baudin, Elisabeth, Björkman, Anders, Bompart, Francois, Bonnet, Maryline, Borrmann, Steffen, Bousema, Teun, Carrara, Verena I, Cenci, Fabio, Checchi, Francesco, Cot, Michel, Dahal, Prabin, D'Alessandro, Umberto, Deloron, Phillippe, Djimdé, Abdoulaye, Dondorp, Arjen, Dorsey, Grant, Doumbo, Ogobara K, Drakeley, Chris J, Duparc, Stephan, Espie, Emmanuelle, Faiz, Abul, Falade, Catherine O, Fanello, Caterina, Faucher, Jean-François, Faye, Babacar, Filler, Scott, Fofana, Bakary, Fogg, Carole, Gansane, Adama, Gaye, Oumar, Genton, Blaise, Gething, Peter W, Gonzalez, Raquel, Grandesso, Francesco, Greenwood, Brian, Grivoyannis, Anastasia, Guerin, Philippe J, Hamed, Kamal, Hatz, Cristoph, Hay, Simon I, Hodel, Eva Maria, Humphreys, Georgina S, Hwang, Jimee, Janssens, Bart, Juma, Elizabeth, Kachur, S Patrick, Kager, Piet, Kamya, Moses R, Kapulu, Melissa, Karema, Corine, Kayentao, Kassoum, Kiechel, Jean R, Kofoed, Poul-Erik, Lameyre, Valerie, Lee, Sue J, Lell, Bertrand, Lima, Nines, Marsh, Kevin, Mårtensson, Andreas, Massougbodji, Achille, Mayxay, Mayfong, McGready, Rose, Menan, Hervé, Menendez, Clara, Mens, Petra, Meremikwu, Martin, Mockenhaupt, Frank P, Moreira, Clarissa, Nabasumba, Carolyn, Nambozi, Michael, Ndiaye, Jean-Louis, Newton, Paul N, Ngasala, Billy E, Nosten, Francois, Nsanzabana, Christian, Offianan, Andre Toure, Oguike, Mary, Ogutu, Bernards R, Olliaro, Piero, Omar, Sabah A, Osorio, Lyda, Owusu-Agyei, Seth, Penali, Louis K, Pene, Mbaye, Peshu, Judy, Premji, Zul, Price, Ric N, Ramharter, Michael, Rombo, Lars, Roper, Cally, Rosenthal, Philip J, Sagara, Issaka, Sawa, Patrick, Schallig, Henk D F H, Schramm, Birgit, Shekalaghe, Seif A, Sibley, Carol H, Sirima, Sodiomon, Smithuis, Frank, Sow, Doudou, Staedke, Sarah G, Stepniewska, Kasia, Sutanto, Inge, Sutherland, Colin J, Swarthout, Todd D, Syafruddin, Din, Sylla, Khadime, Talisuna, Ambrose O, Taylor, Walter R, Tema, Emmanuel A, Ter Kuile, Feiko, Tinto, Halidou, Tjitra, Emiliana, Ursing, Johan, Valecha, Neena, van den Broek, Ingrid, van Herp, Michel, van Vugt, Michele, Ward, Stephen A, White, Nicholas J, Winstanley, Peter A, Woodrow, Charles J, Yeka, Adoke, Zwang, Julien, and WWARN Gametocyte Study Group

Subjects
Male, 0301 basic medicine, gametocytes, Plasmodium falciparum/drug effects, Artemisinins/therapeutic use, Amodiaquine/therapeutic use, chemistry.chemical_compound, 0302 clinical medicine, Recurrence, Malaria, Falciparum, Artemisinin, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Medicine(all), Microscopy, biology, Mefloquine, Malaria, Falciparum/drug therapy, Hazard ratio, General Medicine, Middle Aged, Artemisinins, 3. Good health, Drug Combinations, Child, Preschool, Drug Therapy, Combination, Research Article, medicine.drug, medicine.medical_specialty, plasmodium falciparum, Plasmodium falciparum, 030231 tropical medicine, Gametocyte, malaria, Malària, Amodiaquine, Host-Parasite Interactions, Antimalarials, 03 medical and health sciences, Internal medicine, parasitic diseases, medicine, Humans, Proportional Hazards Models, Resistència als medicaments, drug resistance, business.industry, medicine.disease, biology.organism_classification, Malaria, Logistic Models, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], 030104 developmental biology, chemistry, Host-Parasite Interactions/drug effects, Artesunate, Drug resistance, Antimalarials/therapeutic use, Immunology, business
Abstract

BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify the determinants of gametocyte carriage and the comparative effects of four ACTs: artemether-lumefantrine (AL), artesunate/amodiaquine (AS-AQ), artesunate/mefloquine (AS-MQ), and dihydroartemisinin-piperaquine (DP). METHODS: Factors associated with gametocytaemia prior to, and following, ACT treatment were identified in multivariable logistic or Cox regression analysis with random effects. All relevant studies were identified through a systematic review of PubMed. Risk of bias was evaluated based on study design, methodology, and missing data. RESULTS: The systematic review identified 169 published and 9 unpublished studies, 126 of which were shared with the WorldWide Antimalarial Resistance Network (WWARN) and 121 trials including 48,840 patients were included in the analysis. Prevalence of gametocytaemia by microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at presentation. After ACT treatment, gametocytaemia appeared in 1.9 % (95 % CI, 1.7-2.1) of patients. The appearance of gametocytaemia was lowest after AS-MQ and AL and significantly higher after DP (adjusted hazard ratio (AHR), 2.03; 95 % CI, 1.24-3.12; P = 0.005 compared to AL) and AS-AQ fixed dose combination (FDC) (AHR, 4.01; 95 % CI, 2.40-6.72; P < 0.001 compared to AL). Among individuals who had gametocytaemia before treatment, gametocytaemia clearance was significantly faster with AS-MQ (AHR, 1.26; 95 % CI, 1.00-1.60; P = 0.054) and slower with DP (AHR, 0.74; 95 % CI, 0.63-0.88; P = 0.001) compared to AL. Both recrudescent (adjusted odds ratio (AOR), 9.05; 95 % CI, 3.74-21.90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001) infections with asexual-stage parasites were strongly associated with development of gametocytaemia after day 7. CONCLUSIONS: AS-MQ and AL are more effective than DP and AS-AQ FDC in preventing gametocytaemia shortly after treatment, suggesting that the non-artemisinin partner drug or the timing of artemisinin dosing are important determinants of post-treatment gametocyte dynamics.

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