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4 results on '"Rizzi, Marco"'

3. Awareness, discussion and non-prescribed use of HIV pre-exposure prophylaxis among persons living with HIV/AIDS in Italy: a Nationwide, cross-sectional study among patients on antiretrovirals and their treating HIV physicians

Author

Palummieri, Antonio, De Carli, Gabriella, Rosenthal, Éric, Cacoub, Patrice, Mussini, Cristina, Puro, Vincenzo, Ladisa, Nicoletta, Maggiolo, Franco, Rizzi, Marco, Calza, Leonardo, Colangeli, Vincenzo, Girometti, Nicolò, Ferraresi, Alice, Focà, Emanuele, Giorgetti, Pier Francesco, Pezzoli, Maria Chiara, Celesia, Benedetto Maurizio, Pinzone, Marilia Rita, Bruno, Tiziana, Viada, Alberto, Vitullo, Davide, Guardigni, Viola, Sighinolfi, Laura, Ambu, Silvia, Bartolozzi, Dario, Campolmi, Irene, Meli, Massimo, Pozzi, Marco, Sterrantino, Gaetana, Matarazzo, Filippo, Purificato, Francesco, Anzalone, Enza, Luciano, Sarracino, Lichtner, Miriam, Raffaella, Marocco, Mercurio, Vito Sante, Lorena, Paula Castelli, Martorelli, Paoli, Linzalone, Angela, Esoka, Franklyn, Raise, Eseme Enzo, Bossolasco, Simona, Castagna, Antonella, Cernuschi, Massimo, Cinque, Paola, Fumagalli, Luca, Gaiera, Giovanni, Gianotti, Nicola, Guffanti, Monica, Maillard, Miriam, Nozza, Silvia, Spagnuolo, Vincenzo, Uberti-Foppa, Caterina, Borghi, Vanni, Cristina Mussini, Null, Chessa, Luchino, Matta, Laura, Pasetto, Maria Cristina, D'Esposito, Giuseppe, Franco, Alfredo, Izzo, Crescenzo Maria, Manzillo, Elio, Marocco, Alessandro, Micillo, Raffaele, Pizzella, Teresa, Martini, Salvatore, Moretti, Maria Vittoria, Schiaroli, Elisabetta, Catalani, Corrado, Giorgi, Marina, Menichini, Beatrice, Trezzi, Michele, Migliore, Simona, Ballardini, Giuseppe, Barchi, Enrico, Garlassi, Elisa, Magnani, Giacomo, Prati, Francesca, Testa, Lucia, Ursitti, Maria Alessandra, Zoboli, Giuliana, Teti, Elisabetta, Buonomini, Anna Rita, Cerva, Carlotta, Giovanni D'Anna, Null, Ilari, Barbara, Malagnino, Vincenzo, Sarmati, Loredana, Ammassari, Adriana, Bellagamba, Rita, Evangelo, Boumis, Cicalini, Stefania, Liuzzi, Giuseppina, Loiacono, Laura, Migliorisi, Paolo, Nicastri, Emanuele, Pinnetti, Carmela, Sampaolesi, Alessandro, Tommasi, Chiara, Zaccarelli, Mauro, Angileri, Rosalia, Coscia, Maria, D'Ettorre, Gabriella, Fantauzzi, Alessandra, Iaiani, Giancarlo, Mezzaroma, Ivano, Paoletti, Francesca, Zaccaria, Maria, De Luca, Andrea, Rossetti, Barbara, Pomi, Manola, Carnicelli, Nicoletta, Gonnelli, Angela, Marri, Daniele, Toscano, Lucia, Armignacco, Orlando, Caterini, Anna Rita, Caterini, Antonio Luciano, Di Filippo, Barbara, Ialungo, Anna Maria, Rastrelli, Elena, Sabatini, Rita, Palummieri, A, De Carli, G, Rosenthal, É, Cacoub, P, Mussini, C, Puro, V, the PrEPventHIV Italy Study, Group, Castagna, A, Spagnuolo, V, and Uberti-Foppa, C

Subjects
0301 basic medicine, Male, Anti-HIV agents, Pediatrics, Health Knowledge, Attitudes, Practice, Cross-sectional study, Alternative medicine, Psychological intervention, Human immunodeficiency virus (HIV), HIV Infections, Self Medication, Anti-HIV agent, Logistic regression, medicine.disease_cause, Pre-exposure prophylaxis, Sexual and Gender Minorities, 0302 clinical medicine, Surveys and Questionnaires, 030212 general & internal medicine, HIV physician, Dosing regimen, virus diseases, Persons Living with HIV/AIDS (PLWHA), Infectious Diseases, Italy, HIV physicians, Female, Research Article, Adult, medicine.medical_specialty, Sexual Behavior, HIV prevention, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Physicians, medicine, Humans, lcsh:RC109-216, Acquired Immunodeficiency Syndrome, business.industry, medicine.disease, 030112 virology, Pre-Exposure Prophylaxis (PrEP), Cross-Sectional Studies, Family medicine, Pre-Exposure Prophylaxis, business
Abstract

Background Before Pre-Exposure Prophylaxis (PrEP) was officially recommended and made available, a few surveys among gay and bisexual men, and persons living with HIV/AIDS (PLWHA), identified an informal use of antiretrovirals (ARVs) for PrEP among HIV-negative individuals. Before PrEP availability in Italy, we aimed to assess whether PLWHA in Italy shared their ARVs with HIV-negative individuals, whether they knew people who were on PrEP, and describe the level of awareness and discussion on this preventive measure among them and people in their close circle. Methods Two anonymous questionnaires investigating personal characteristics and PrEP awareness, knowledge, and experience were proposed to HIV specialists and their patients on ARVs in a one-week, cross-sectional survey (December 2013–January 2014). Among PLWHA, a Multivariable Logistic Regression analysis was conducted to identify factors associated with PrEP discussion with peers (close circle and/or HIV associations), and experience (use in close circle and/or personal ARV sharing). Results Eighty-seven specialists in 31 representative Infectious Diseases departments administered the questionnaire to 1405 PLWHA. Among specialists, 98% reported awareness, 65% knew the dosage schedule, and 14% had previously suggested or prescribed PrEP. Among PLWHA, 45.6% were somehow aware, discussed or had direct or indirect experience of PrEP: 38% “had heard” of PrEP, 24% were aware of studies in HIV-negative individuals demonstrating a risk reduction through the use of ARVs, 22% had discussed PrEP, 12% with peers; 9% reported PrEP use in close circle and 1% personal ARV sharing. Factors predictive of either PrEP discussion with peers or experience differed between men and women, but across all genders were mainly related to having access to information, with HIV association membership being the strongest predictor. Conclusions At a time and place where there were neither official information nor proposals or interventions to guide public policies on PrEP in Italy, a significant number of PLWHA were aware of it, and approximately 10% reported PrEP use in their close circle, although they rarely shared their ARVs with uninfected people for this purpose. Official policies and PrEP availability, along with implementation programs, could avoid risks from uncontrolled PrEP procurement and self-administration practices. Electronic supplementary material The online version of this article (10.1186/s12879-017-2819-5) contains supplementary material, which is available to authorized users.

Published
2017

4. Predicting the occurrence of embolic events: an analysis of 1456 episodes of infective endocarditis from the Italian study on endocarditis (SEI).

Author

Rizzi, Marco, Ravasio, Veronica, Carobbio, Alessandra, Mattucci, Irene, Crapis, Massimo, Stellini, Roberto, Pasticci, Maria Bruna, Chinello, Pierangelo, Falcone, Marco, Grossi, Paolo, Barbaro, Francesco, Pan, Angelo, Viale, Pierluigi, and Durante-Mangoni, Emanuele

Subjects
*INFECTIVE endocarditis, *EMBOLISMS, *DISEASE risk factors, *ANTI-infective agents, *ETIOLOGY of diseases
Abstract

Background Embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. We analyzed the database of the prospective cohort study SEI in order to identify factors associated with the occurrence of embolic events and to develop a scoring system for the assessment of the risk of embolism. Methods We retrospectively analyzed 1456 episodes of infective endocarditis from the multicenter study SEI. Predictors of embolism were identified. Risk factors identified at multivariate analysis as predictive of embolism in left-sided endocarditis, were used for the development of a risk score: 1 point was assigned to each risk factor (total risk score range: minimum 0 points; maximum 2 points). Three categories were defined by the score: low (0 points), intermediate (1 point), or high risk (2 points); the probability of embolic events per risk category was calculated for each day on treatment (day 0 through day 30). Results There were 499 episodes of infective endocarditis (34%) that were complicated by ⩾ 1 embolic event. Most embolic events occurred early in the clinical course (first week of therapy: 15.5 episodes per 1000 patient days; second week: 3.7 episodes per 1000 patient days). In the total cohort, the factors associated with the occurrence of embolism at multivariate analysis were prosthetic valve localization (odds ratio, 1.84), right-sided endocarditis (odds ratio, 3.93), Staphylococcus aureus etiology (odds ratio, 2.23) and vegetation size ⩾ 13 mm (odds ratio, 1.86). In left-sided endocarditis, Staphylococcus aureus etiology (odds ratio, 2.1) and vegetation size ⩾ 13 mm (odds ratio, 2.1) were independently associated with embolic events; the 30-day cumulative incidence of embolism varied with risk score category (low risk, 12%; intermediate risk, 25%; high risk, 38%; p < 0.001). Conclusions Staphylococcus aureus etiology and vegetation size are associated with an increased risk of embolism. In left-sided endocarditis, a simple scoring system, which combines etiology and vegetation size with time on antimicrobials, might contribute to a better assessment of the risk of embolism, and to a more individualized analysis of indications and contraindications for early surgery. [ABSTRACT FROM AUTHOR]

Published
2014
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