1. Short-term spontaneous fluctuations of HBV DNA levels in a Senegalese population with chronic hepatitis B
- Author
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Loïc Chartier, Aboubakry Diallo, Papa Saliou Mbaye, Muriel Vray, Jean Daveiga, Jean-Marc Debonne, Jean-Marie Sire, François Simon, Anna Sarr, Sarah Maylin, Marie-Louise Evra, and Fatou Fall
- Subjects
Adult ,Male ,HBsAg ,medicine.medical_specialty ,Pathology ,Hepatitis B virus ,Population ,medicine.disease_cause ,HBV DNA level ,Gastroenterology ,Medical microbiology ,Hepatitis B, Chronic ,Internal medicine ,Genotype ,medicine ,Humans ,Serologic Tests ,education ,Genotyping ,education.field_of_study ,Hepatitis B Surface Antigens ,business.industry ,virus diseases ,HBsAg quantification ,Alanine Transaminase ,Viral Load ,Short-term spontaneous fluctuation ,digestive system diseases ,Senegal ,3. Good health ,Infectious Diseases ,Parasitology ,DNA, Viral ,Female ,Chronic Hepatitis B ,business ,Viral load ,Research Article - Abstract
Background We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluctuations. Method A total of 87 patients with persistent normal ALT values were enrolled in the study. Serum samples were obtained at three different visits, with an interval of 2 months (M0, M2, and M4), and without initiating anti HBV treatment. Levels of HBV DNA, quantitative HBsAg, ALT and AST, genotyping and viral DNA mutations were analyzed. Results Among the 87 patients, genotype E was predominant (75%). The median HBV DNA level was 2.9 log10 IU/mL [2.2-3.4], 2.7 log10 IU/mL [2.1-3.6] and 2.7 log10 IU/mL [2.1-3.4] at M0, M2 and M4, respectively. The values ranged from
- Published
- 2014