1. Two confirmed cases of severe fever with thrombocytopenia syndrome with pneumonia: implication for a family cluster in East China.
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Yiyi Zhu, Huanyu Wu, Jie Gao, Xin Zhou, Renyi Zhu, Chunzhe Zhang, Hongling Bai, Abdullah, Abu S., Hao Pan, Zhu, Yiyi, Wu, Huanyu, Gao, Jie, Zhou, Xin, Zhu, Renyi, Zhang, Chunzhe, Bai, Hongling, and Pan, Hao
- Subjects
THROMBOCYTOPENIA ,PNEUMONIA ,EPIDEMIOLOGY ,INFECTIOUS disease transmission ,PUBLIC health - Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) was first reported in China in 2011. Human-to-human transmission of the virus occurred occasionally in family clusters. However, pneumonia as an onset syndrome was not common in most SFTS cases. Our aim is to report a family cluster of SFTS with clinical manifestation of pneumonia in Shanghai.Methods: Epidemiologic investigations were conducted when a family cluster of severe fever with thrombocytopenia syndrome virus (SFTSV) infection was identified in Shanghai in June 2016. Samples were collected from two secondary cases and two close contacts with fever. SFTSV was detected by Real-Time reverse transcription polymerase chain reaction (RT-PCR).Results: There were two confirmed STFS cases and one potential index case. The potential index case became ill on 21 May and died on 31 May. Case A had onset from 4 to 23 June and case B from 8 June to 25 June. All the three cases experienced pneumonia at the early stage of SFTSV infection. Three (3) out of thirty two (32) close contacts had symptoms of fever or cough but were detected STFSV negative by real-time RT-PCR. According to epidemiologic investigations, the potential index case had outdoor activities on a nearby hill. A tick bite could have been the reason for the SFTSV infection in the potential index case as ticks were found both in grassland or shrubs on the hill and also found on mice caught in her house. Both cases A and B had provided bedside care for the potential index case without any protection and had contacted with blood and other body fluids.Conclusion: It was a family cluster of SFTSV infection imported from Jiangsu province located in the east of China. We suggested to become alert to atypical SFTSV infected cases. [ABSTRACT FROM AUTHOR]- Published
- 2017
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