1. Personality, Alzheimer's disease and behavioural and cognitive symptoms of dementia: the PACO prospective cohort study protocol
- Author
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Jean-Michel Dorey, Pierre Krolak-Salmon, Catherine Padovan, Florence Dibie-Racoupeau, Marie-Anne Hénaff, Denis Federico, Bernard Laurent, Michel Benoit, Marie-Odile Barrellon, Nawele Boublay, Zaza Makaroff, Isabelle Rouch, Sandrine Harston, Dupuis, Christine, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Unité de Gériatrie, Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre Mémoire de Ressources et de Recherche (CMRR Lyon), Unité de Neurologie, CHU Saint-Etienne-Centre Mémoire de Ressources et de Recherche (CMRR Saint-Etienne), Psychiatrie, Centre Hospitalier le Vinatier [Bron], Pôle Information Médicale Evaluation Recherche (IMER), Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pôle de Gérontopsychiatrie, Hôpital Saint Jean de Dieu, Hôpital Xavier Arnozan - CHU de Bordeaux, Unité de Psychiatrie, Hôpital Pasteur [Nice] (CHU), Médecine Gériatrie, Centre hospitalier L'Hôpital du Gier (Saint-Chamond), The PACO study has been funded by the National French Program ofHospital Clinical Research (Programme Hospitalier de Recherche CliniqueNational 2009 and 2010), France Alzheimer, Janssen laboratory grants., The PACO Group : MO Barrellon, M Benoit, B Laurent, Z Makaroff, F Blanc, H Mollion, O Moreaud, C Padovan, X de Pétigny, P Rebaudet, S Relland, P H Robert, JM Dorey, I Roullet Solignac, O Rouaud, I Rouch, M Bonnefoy, F Sellal, C Terrat and A Vighetto., N Boublay, S Brengarth, MH Coste, B Croisile, D Federico, M Debray, F Dibie-Racoupeau, I Gallice, S Gaujard, P Grosmaitre, S Harston, MA Hénaff, P Krolak-Salmon, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé ( SNA-EPIS ), Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre Hospitalier Universitaire de Saint-Etienne, Centre Mémoire de Ressources et de Recherche ( CMRR Lyon ) -Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), CHU Saint-Etienne-Centre Mémoire de Ressources et de Recherche ( CMRR Saint-Etienne ), Pôle Information Médicale Evaluation Recherche ( IMER ), Hospices Civils de Lyon ( HCL ), Centre de recherche en neurosciences de Lyon ( CRNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Hôpital Pasteur [Nice] ( CHU ), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,medicine.medical_specialty ,Personality Inventory ,media_common.quotation_subject ,Population ,[ SDV.MHEP.GEG ] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Neuropsychological Tests ,Study Protocol ,Cognition ,Social cognition ,Alzheimer Disease ,medicine ,Dementia ,Personality ,Humans ,Behaviour ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Prospective Studies ,10. No inequality ,Psychiatry ,education ,media_common ,Aged ,education.field_of_study ,[SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,business.industry ,[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Caregivers ,[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Disease Progression ,Quality of Life ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Geriatrics and Gerontology ,Personality Assessment Inventory ,Alzheimer's disease ,business ,Alzheimer’s disease ,Cohort study ,Follow-Up Studies - Abstract
Alzheimer’s disease is characterised by a loss of cognitive function and behavioural problems as set out in the term “Behavioural and Psychological Symptoms of Dementia”. These behavioural symptoms have heavy consequences for the patients and their families. A greater understanding of behavioural symptoms risk factors would allow better detection of those patients, a better understanding of crisis situations and better management of these patients. Some retrospective studies or simple observations suggested that personality could play a role in the occurrence of behavioural symptoms. Finally, performance in social cognition like facial recognition and perspective taking could be linked to certain personality traits and the subsequent risks of behavioural symptoms. We propose to clarify this through a prospective, multicentre, multidisciplinary study. Main Objective: - To assess the effect of personality and life events on the risk of developing behavioural symptoms. Secondary Objectives: - To evaluate, at the time of inclusion, the connection between personality and performance in social cognition tests; - To evaluate the correlation between performance in social cognition at inclusion and the risks of occurrence of behavioural symptoms; - To evaluate the correlation between regional cerebral atrophy, using brain Magnetic Resonance Imaging at baseline, and the risk of behavioural symptoms. Study type and Population: Prospective multicentre cohort study with 252 patients with Alzheimer’s disease at prodromal or mild dementia stage. The inclusion period will be of 18 months and the patients will be followed during 18 months. The initial evaluation will include: a clinical and neuropsychological examination, collection of behavioural symptoms data (Neuropsychiatric-Inventory scale) and their risk factors, a personality study using both a dimensional (personality traits) and categorical approach, an inventory of life events, social cognition tests and an Magnetic Resonance Imaging. Patients will be followed every 6 months (clinical examination and collection of behavioural symptoms data and risk factors) during 18 months. This study aims at better identifying the patients with Alzheimer’s disease at high risk of developing behavioural symptoms, to anticipate, detect and quickly treat these disorders and so, prevent serious consequences for the patient and his caregivers. ClincalTrials.gov: NCT01297140
- Published
- 2014
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