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Start Over Author "Li-Wei Cho" Journal bmc endocrine disorders
2 results on '"Li-Wei Cho"'

1. Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

Author

Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed, and Stephen L Atkin

Subjects
Polycystic ovary syndrome, Androsterone glucuronide, DHEAS, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Abstract Background Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects. Methods Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS. Total testosterone, dehydroepiandrosterone sulphate (DHEAS), ADTG, and androstenedione were analysed using gold standard tandem mass spectrometry, and the free androgen index (FAI) was calculated. Results Total testosterone, ADTG and androstendione levels did not differ between non-obese (body mass index (BMI) ≤25 kg/m2) and obese PCOS (BMI >25 kg/m2) but all were significantly higher than for controls (p

Published
2017
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2. Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

Author

Stephen L. Atkin, Brian G. Keevil, Li Wei Cho, Lina Ahmed, Thozhukat Sathyapalan, Anne-Marie Coady, Eric S. Kilpatrick, and Adrian Miller

Subjects
Adult, 030213 general clinical medicine, medicine.medical_specialty, Androsterone glucuronide, endocrine system diseases, Adolescent, medicine.drug_class, DHEAS, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Androsterone, lcsh:Diseases of the endocrine glands. Clinical endocrinology, White People, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Insulin resistance, Sex hormone-binding globulin, Internal medicine, medicine, Humans, Obesity, Polycystic ovary syndrome, lcsh:RC648-665, biology, Free androgen index, business.industry, Dehydroepiandrosterone Sulfate, nutritional and metabolic diseases, General Medicine, medicine.disease, Androgen, Polycystic ovary, female genital diseases and pregnancy complications, Endocrinology, chemistry, biology.protein, Female, business, Body mass index, Biomarkers, Research Article
Abstract

Background Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects. Methods Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS. Total testosterone, dehydroepiandrosterone sulphate (DHEAS), ADTG, and androstenedione were analysed using gold standard tandem mass spectrometry, and the free androgen index (FAI) was calculated. Results Total testosterone, ADTG and androstendione levels did not differ between non-obese (body mass index (BMI) ≤25 kg/m2) and obese PCOS (BMI >25 kg/m2) but all were significantly higher than for controls (p

Published
2017

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