1. Differences and associations of metabolic and vitamin D status among patients with and without sub-clinical hypothyroid dysfunction
- Author
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Shaun Sabico, Sobhy M. Yakout, Nasser M. Al-Daghri, Khalid M Alkhrafy, Omar S. Al-Attas, Ahmed S Al-Ghamdi, Badurudeen Mahmood Buhary, Mussa H. Almalki, Naji Aljohani, Abdulaziz F Alkabba, Abdulaziz M. Al-Othman, and Majed S. Alokail
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Population ,Saudi ,chemistry.chemical_compound ,Internal medicine ,Diabetes mellitus ,Vitamin D and neurology ,medicine ,Obesity ,education ,Subclinical infection ,education.field_of_study ,medicine.diagnostic_test ,Cholesterol ,business.industry ,Thyroid dysfunction ,General Medicine ,medicine.disease ,Endocrinology ,chemistry ,Dyslipidemia ,Lipid profile ,business ,Body mass index ,Research Article - Abstract
Background Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of the population suffer from hypovitaminosis D ( Methods A total of 94 consenting adult Saudis [52 controls (without subclinical hypothyroidism), 42 cases (previously diagnosed subjects)] were included in this cross-sectional study. Anthropometrics were obtained and fasting blood samples were taken for ascertaining lipid and thyroid profile, as well as measuring PTH, 25(OH) vitamin D and calcium. Results Cases had a significantly higher body mass index than the controls (p p = 0.001). A significant positive association between HDL-cholesterol and PTH (R = 0.56; p = 0.001), as well as a negative and modestly significant negative association between LDL-cholesterol and PTH (R = - 20.0; p = 0.04) were observed. FT3 was inversely associated with circulating 25 (OH) vitamin D (R = -0.25; p = 0.01). Conclusions Patients with hypothyroid dysfunction possess several cardiometabolic risk factors that include obesity and dyslipidemia. The association between PTH and cholesterol levels as well as the inverse association between vitamin D status and FT3 needs to be reassessed prospectively on a larger scale to confirm these findings.
- Published
- 2013