1. The hypotensive effect of salt substitutes in stage 2 hypertension: a systematic review and meta-analysis
- Author
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Sadegh Jafarnejad, Hamed Mirzaei, Cain C. T. Clark, Mohsen Taghizadeh, and Armin Ebrahimzadeh
- Subjects
Hypertension ,Salt substitutes ,Systolic blood pressure ,Diastolic blood pressure ,Meta-analysis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Hypertension (HTN) is a ubiquitous risk factor for numerous non-communicable diseases, including cardiovascular disease and stroke. There are currently no wholly effective pharmacological therapies for subjects with HTN. However, salt substitutes have emerged as a potential therapy for the treatment of HTN. The aim of the present study was to assess the effect of salt substitutes on reducing systolic blood pressure (SBP) and diastolic BP (DBP), following a meta-analysis of randomized controlled trials. Methods Studies were found via systematic searches of the Pubmed/Medline, Scopus, Ovid, Google Scholar and Cochrane library. Ten studies, comprised of 11 trials and 1119 participants, were included in the meta-analysis. Results Pooled weighted mean differences showed significant reductions of SBP (WMD − 8.87 mmHg; 95% CI − 11.19, − 6.55, p
- Published
- 2020
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