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Start Over Author "Andreas Kortgen" Journal bmc cardiovascular disorders
2 results on '"Andreas Kortgen"'

1. Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Author

Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, Jochen Renner, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Frank Kletzin, Jan Roesner, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F. Brandes, Martin Bauer, Andreas Kortgen, Sebastian N. Stehr, Maria Wittmann, Georg Baumgarten, Rafael Struck, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Michael Sander, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Frauke Degenhardt, Andre Franke, Soeren Mucha, Lukas Tittmann, Madeline Kohlhaas, Georg Fuernau, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm, and RIPHeart-Study Collaborators

Subjects
Genome-wide association study, Cardiac surgery, Atrial fibrillation, Delirium, Myocardial infarction, Acute kidney injury, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p

Published
2019
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2. Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study

Author

Sabine, Westphal, Christian, Stoppe, Matthias, Gruenewald, Berthold, Bein, Jochen, Renner, Jochen, Cremer, Mark, Coburn, Gereon, Schaelte, Andreas, Boening, Bernd, Niemann, Frank, Kletzin, Jan, Roesner, Ulrich, Strouhal, Christian, Reyher, Rita, Laufenberg-Feldmann, Marion, Ferner, Ivo F, Brandes, Martin, Bauer, Andreas, Kortgen, Sebastian N, Stehr, Maria, Wittmann, Georg, Baumgarten, Rafael, Struck, Tanja, Meyer-Treschan, Peter, Kienbaum, Matthias, Heringlake, Julika, Schoen, Michael, Sander, Sascha, Treskatsch, Thorsten, Smul, Ewa, Wolwender, Thomas, Schilling, Frauke, Degenhardt, Andre, Franke, Soeren, Mucha, Lukas, Tittmann, Madeline, Kohlhaas, Georg, Fuernau, Oana, Brosteanu, Dirk, Hasenclever, Kai, Zacharowski, Patrick, Meybohm, and Norbert, Roewer

Subjects
Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Myocardial Infarction, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Atrial Fibrillation, Clinical endpoint, Phosphoprotein Phosphatases, Multicenter Studies as Topic, 030212 general & internal medicine, Myocardial infarction, Stroke, Randomized Controlled Trials as Topic, Acute kidney injury, Atrial fibrillation, Acute Kidney Injury, Middle Aged, Cardiac surgery, 3. Good health, Treatment Outcome, Cohort, Cardiology, Dual-Specificity Phosphatases, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, medicine.medical_specialty, Genome-wide association study, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Cardiac Surgical Procedures, Aged, business.industry, HSC70 Heat-Shock Proteins, Delirium, Ryanodine Receptor Calcium Release Channel, medicine.disease, Cytoskeletal Proteins, lcsh:RC666-701, Mitogen-Activated Protein Kinase Phosphatases, business
Abstract

Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p

Published
2018

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