1. Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature.
- Author
-
Perrone AM, Girolimetti G, Cima S, Kurelac I, Livi A, Caprara G, Santini D, Castellucci P, Morganti AG, Gasparre G, and De Iaco P
- Subjects
- Adenocarcinoma genetics, Adenocarcinoma surgery, DNA, Mitochondrial genetics, Endometrial Neoplasms genetics, Endometrial Neoplasms surgery, Female, Humans, Inguinal Canal surgery, Lymph Nodes surgery, Middle Aged, Neoplasm Grading, Adenocarcinoma secondary, Endometrial Neoplasms pathology, Inguinal Canal pathology, Lymph Nodes pathology
- Abstract
Background: Extra-abdominal metastases in low grade endometrial carcinoma are rare events. Inguinal lymphatic spread occurs usually in advanced disease and is associated with abdominal lymph nodes involvement. To our knowledge, isolated inguinal lymph node metastases in patients with early endometrial carcinoma have never been described thus far., Case Presentation: We present an uncommon case of inguinal lymph node metastasis in a 51-year old patient with early endometrial disease without other metastatic involvement. The metastatic loci were analyzed with the recently validated method of mitochondrial DNA sequencing to demonstrate clonality of the lesions., Conclusions: We describe the first case of inguinal metastasis from intramucous endometrial carcinoma; this case confirms the unpredictable spread of endometrial neoplasia and the importance of both patient's history and physical examination in good clinical practice.
- Published
- 2018
- Full Text
- View/download PDF