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Your search keyword '"Anesthetic preconditioning"' showing total 2 results
Start Over Descriptor "Anesthetic preconditioning" Journal bmc anesthesiology
2 results on '"Anesthetic preconditioning"'

1. Repeated remote ischemic preconditioning and isoflurane anesthesia in an experimental model of renal ischemia-reperfusion injury.

Author

Menting, Theo P., Ergun, Mehmet, Bruintjes, Moira H. D., Wever, Kimberley E., Lomme, Roger M. L. M., van Goor, Harry, and Warlé, Michiel C.

Subjects
*ANIMAL experimentation, *HISTOLOGICAL techniques, *ISCHEMIA, *ISOFLURANE, *KIDNEY function tests, *KIDNEYS, *RATS, *REPERFUSION injury, *RESEARCH funding, *T-test (Statistics), *STATISTICAL power analysis, *NEPHRECTOMY, *DESCRIPTIVE statistics, *ISCHEMIC preconditioning
Abstract

Background: In animal studies, remote ischemic preconditioning (RIPC) and anesthetic preconditioning are successful in reducing renal ischemia reperfusion injury (IRI), however the protective effect of RIPC may be improved by repeating the RIPC stimulus. Methods: Sprague-Dawley rats underwent unilateral nephrectomy followed by 30 min of renal pedicle clamping. Animals were allocated into six groups: sham, control (IRI), RepISO (daily isoflurane anesthesia), RIPC (single dose isoflurane anesthesia and single dose RIPC), RepISO + RIPC (7-day isoflurane anesthesia and single dose RIPC) and RepISO + RepRIPC (7-day isoflurane anesthesia with 7-day RIPC). RIPC was applied by 3x5 min of cuff inflation on both thighs. Serum creatinine and urea levels were measured and histology was obtained at day two. Results: RepISO diminished renal IRI, as reflected by a significant reduction in serum creatinine levels as compared to the control group, 170 ± 74 resp. 107 ± 29 µmol/L. The other preconditioning protocols showed similar reduction in serum creatinine levels as compared to the control group. No significant differences were observed between the different preconditioning protocols. For urea levels, only RepISO + RIPC resulted in significantly lower levels as compared to the control group, 14 ± 4 resp. 22 ± 7 mmol/L (p = 0.010). In the preconditioning groups only RepISO showed less histological damage as compared to controls 1.73 ± 1.19 resp. 2.91 ± 1.22 (p = 0.032). Conclusions: In this study no additional protective effect of repeated ischemic preconditioning was observed as compared to single dose RIPC. Repeated administration of isoflurane provided stronger protection against renal IRI as compared to single dose isoflurane. [ABSTRACT FROM AUTHOR]

Published
2017
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2. Repeated remote ischemic preconditioning and isoflurane anesthesia in an experimental model of renal ischemia-reperfusion injury

Author

Roger M. L. M. Lomme, Theo P. Menting, Harry van Goor, Mehmet Ergün, Kimberley E. Wever, Michiel C. Warlé, and Moira H.D. Bruintjes

Subjects
Male, medicine.medical_specialty, Anesthetic preconditioning, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 030204 cardiovascular system & hematology, Kidney, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Anesthesiology, medicine, Animals, Urea, Animal experiment, Ischemic Preconditioning, Renal ischemia reperfusion, Creatinine, Isoflurane, business.industry, Protective Factors, Repeated remote ischemic preconditioning, 3. Good health, Rats, Disease Models, Animal, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], chemistry, Anesthesia, Reperfusion Injury, Anesthetic, Ischemic preconditioning, Animal studies, business, 030217 neurology & neurosurgery, Ischemia reperfusion injury, medicine.drug, Research Article
Abstract

Contains fulltext : 169810.pdf (Publisher’s version ) (Open Access) BACKGROUND: In animal studies, remote ischemic preconditioning (RIPC) and anesthetic preconditioning are successful in reducing renal ischemia reperfusion injury (IRI), however the protective effect of RIPC may be improved by repeating the RIPC stimulus. METHODS: Sprague-Dawley rats underwent unilateral nephrectomy followed by 30 min of renal pedicle clamping. Animals were allocated into six groups: sham, control (IRI), RepISO (daily isoflurane anesthesia), RIPC (single dose isoflurane anesthesia and single dose RIPC), RepISO + RIPC (7-day isoflurane anesthesia and single dose RIPC) and RepISO + RepRIPC (7-day isoflurane anesthesia with 7-day RIPC). RIPC was applied by 3x5 min of cuff inflation on both thighs. Serum creatinine and urea levels were measured and histology was obtained at day two. RESULTS: RepISO diminished renal IRI, as reflected by a significant reduction in serum creatinine levels as compared to the control group, 170 +/- 74 resp. 107 +/- 29 mumol/L. The other preconditioning protocols showed similar reduction in serum creatinine levels as compared to the control group. No significant differences were observed between the different preconditioning protocols. For urea levels, only RepISO + RIPC resulted in significantly lower levels as compared to the control group, 14 +/- 4 resp. 22 +/- 7 mmol/L (p = 0.010). In the preconditioning groups only RepISO showed less histological damage as compared to controls 1.73 +/- 1.19 resp. 2.91 +/- 1.22 (p = 0.032). CONCLUSIONS: In this study no additional protective effect of repeated ischemic preconditioning was observed as compared to single dose RIPC. Repeated administration of isoflurane provided stronger protection against renal IRI as compared to single dose isoflurane.

Published
2017

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