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Start Over Author "Dong, Xin" Journal bmc anesthesiology Publisher biomed central
13 results on '"Dong, Xin"'

10. The composite risk index based on frailty predicts postoperative complications in older patients recovering from elective digestive tract surgery: a retrospective cohort study

Author

Chun-Qing Li, Chen Zhang, Fan Yu, Xue-Ying Li, and Dong-Xin Wang

Subjects
Male, Frailty, Research, Malnutrition, Comorbidity, Length of Stay, Risk Assessment, Cohort Studies, Older patient, Postoperative complications, Anesthesiology and Pain Medicine, Digestive system surgical procedures, Anesthesiology, Elective Surgical Procedures, Predictive Value of Tests, Beijing, Humans, RD78.3-87.3, Female, Geriatric Assessment, Aged, Retrospective Studies
Abstract

Background Limitations exist in available studies investigating effect of preoperative frailty on postoperative outcomes. This study was designed to analyze the association between composite risk index, an accumulation of preoperative frailty deficits, and the risk of postoperative complications in older patients recovering from elective digestive tract surgery. Methods This was a retrospective cohort study. Baseline and perioperative data of older patients (age ≥ 65 years) who underwent elective digestive tract surgery from January 1, 2017 to December 31, 2018 were collected. The severity of frailty was assessed with the composite risk index, a composite of frailty deficits including modified frailty index. The primary endpoint was the occurrence of postoperative complications during hospital stay. The association between the composite risk index and the risk of postoperative complications was assessed with a multivariable logistic regression model. Results A total of 923 patients were included. Of these, 27.8% (257) developed postoperative complications. Four frailty deficits, i.e., modified frailty index ≥0.27, malnutrition, hemoglobin P P P P P Conclusion For older patients following elective digestive tract surgery, high preoperative composite risk index, a combination of frailty deficits, was independently associated with an increased risk of postoperative complications.

Published
2022

11. The effect of dexmedetomidine on intraoperative blood glucose homeostasis: secondary analysis of a randomized controlled trial

Author

Dong-Xin Wang, Dong-Liang Mu, Chun-Jing Li, and Bo-Jie Wang

Subjects
Blood Glucose, Male, medicine.medical_treatment, Operative Time, 030204 cardiovascular system & hematology, Loading dose, law.invention, 03 medical and health sciences, 0302 clinical medicine, Elderly, Non-cardiac surgery, Randomized controlled trial, 030202 anesthesiology, law, Anesthesiology, Risk Factors, Diabetes mellitus, Monitoring, Intraoperative, medicine, Diabetes Mellitus, Glucose homeostasis, Homeostasis, Humans, RD78.3-87.3, Dexmedetomidine, Saline, Glycemic, Aged, business.industry, Research, Analgesics, Non-Narcotic, medicine.disease, Anesthesiology and Pain Medicine, Anesthesia, Hemostasis, Hyperglycemia, Intraoperative hyperglycemia, Female, business, medicine.drug
Abstract

PurposeTo investigate the effect of dexmedetomidine on intraoperative blood glucose hemostasis in elderly patients undergoing non-cardiac major surgery.MethodsThis was secondary analysis of a randomized controlled trial. Patients in dexmedetomidine group received a loading dose dexmedetomidine (0.6 μg/kg in 10 min before anaesthesia induction) followed by a continuous infusion (0.5 μg/kg/hr) till 1 h before the end of surgery. Patients in control group received volume-matched normal saline at the same time interval. Primary outcome was the incidence of intraoperative hyperglycemia (blood glucose higher than 10 mmol/L).Results303 patients in dexmedetomidine group and 306 patients in control group were analysed. The incidence of intraoperative hyperglycemia showed no statistical significance between dexmedetomidine group and control group (27.4% vs. 22.5%, RR = 1.22, 95%CI 0.92–1.60,P = 0.167). Median value of glycemic variation in dexmedetomidine group (2.5, IQR 1.4–3.7, mmol) was slightly lower than that in control group (2.6, IQR 1.5–4.0, mmol),P = 0.034. In multivariable logistic analysis, history of diabetes (OR 3.007, 95%CI 1.826–4.950,P P P ConclusionsDexmedetomidine presented no effect on intraoperative hyperglycemia in elderly patients undergoing major non-cardiac surgery.Trial registrationPresent study was registered at Chinese Clinical Trial Registry on December 1, 2015 (www.chictr.org.cn, registration number ChiCTR-IPR-15007654).

Published
2021

12. Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial.

Author

Ya-Wei Li, Hui-Juan Li, Huai-Jin Li, Yi Feng, Yao Yu, Xiang-Yang Guo, Yan Li, Bin-Jiang Zhao, Xiao-Yun Hu, Ming-Zhang Zuo, Hong-Ye Zhang, Mei-Rong Wang, Ping Ji, Xiao-Yan Yan, Yang-Feng Wu, and Dong-Xin Wang

Subjects
ANALGESICS, ANESTHESIA, DELIRIUM, EXPERIMENTAL design, EVALUATION of medical care, NARCOTICS, PATIENT-controlled analgesia, EPIDURAL anesthesia, POSTOPERATIVE period, OPERATIVE surgery, RANDOMIZED controlled trials, DATA analysis software
Abstract

Background: Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating factors of postoperative delirium. Neuraxial block is frequently used in combination with general anesthesia for patients undergoing major thoracic and abdominal surgery. Compared with general anesthesia alone and postoperative intravenous analgesia, combined epidural-general anesthesia and postoperative epidural analgesia decreases the requirement of general anesthetics during surgery and provided better pain relief after surgery. However, whether combined epidural-general anesthesia plus epidural analgesia is superior to general anesthesia plus intravenous analgesia in decreasing the incidence of postoperative delirium remains unknown. Methods/design: This is a multicenter, open-label, randomized, parallel-controlled clinical trial. One thousand eight hundred elderly patients (age range 60-90 years) who are scheduled to undergo major thoracic or abdominal surgery are randomized to receive either general anesthesia plus postoperative intravenous analgesia or combined epidural-general anesthesia plus postoperative epidural analgesia. The primary outcome is the 7-day incidence of postoperative delirium. Secondary outcomes include the duration of postoperative delirium, the intensity of pain during the first three days after surgery, the 30-day incidences of postoperative non-delirium complications, the length of stay in hospital after surgery and 30-day all-cause mortality. Discussion: Results of the present study will provide information to guide clinical practice in choosing appropriate anesthesia-analgesia method for elderly patients undergoing major thoracic and abdominal surgery. [ABSTRACT FROM AUTHOR]

Published
2015
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13. Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial.

Author

Li YW, Li HJ, Li HJ, Feng Y, Yu Y, Guo XY, Li Y, Zhao BJ, Hu XY, Zuo MZ, Zhang HY, Wang MR, Ji P, Yan XY, Wu YF, and Wang DX

Subjects
Aged, Aged, 80 and over, Delirium diagnosis, Delirium epidemiology, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Pain, Postoperative diagnosis, Pain, Postoperative prevention & control, Postoperative Complications diagnosis, Postoperative Complications epidemiology, Postoperative Complications prevention & control, Treatment Outcome, Analgesia, Epidural methods, Anesthesia, Epidural methods, Anesthesia, General methods, Anesthesia, Intravenous methods, Delirium prevention & control, Thoracic Surgical Procedures adverse effects
Abstract

Background: Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating factors of postoperative delirium. Neuraxial block is frequently used in combination with general anesthesia for patients undergoing major thoracic and abdominal surgery. Compared with general anesthesia alone and postoperative intravenous analgesia, combined epidural-general anesthesia and postoperative epidural analgesia decreases the requirement of general anesthetics during surgery and provided better pain relief after surgery. However, whether combined epidural-general anesthesia plus epidural analgesia is superior to general anesthesia plus intravenous analgesia in decreasing the incidence of postoperative delirium remains unknown., Methods/design: This is a multicenter, open-label, randomized, parallel-controlled clinical trial. One thousand eight hundred elderly patients (age range 60-90 years) who are scheduled to undergo major thoracic or abdominal surgery are randomized to receive either general anesthesia plus postoperative intravenous analgesia or combined epidural-general anesthesia plus postoperative epidural analgesia. The primary outcome is the 7-day incidence of postoperative delirium. Secondary outcomes include the duration of postoperative delirium, the intensity of pain during the first three days after surgery, the 30-day incidences of postoperative non-delirium complications, the length of stay in hospital after surgery and 30-day all-cause mortality., Discussion: Results of the present study will provide information to guide clinical practice in choosing appropriate anesthesia-analgesia method for elderly patients undergoing major thoracic and abdominal surgery., Trial Registration: The study is registered on ClinicalTrials.gov NCT01661907 and Chinese Clinical Trial Registry ChiCTR-TRC-12002371 .

Published
2015
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