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Your search keyword '"Renal function"' showing total 3 results
Start Over Descriptor "Renal function" Topic kidney function tests Journal bmc anesthesiology Publisher biomed central
3 results on '"Renal function"'

1. Effects of terlipressin infusion during hepatobiliary surgery on systemic and splanchnic haemodynamics, renal function and blood loss: a double-blind, randomized clinical trial

Author

Mohammed Geddawy, Jehan Ahmed Sayed, Ramy A. Hassan, Ragaa Herdan, Osama A Ibraheim, Tameem M. Ibraheem, Mostafa Samy Abbas, Magdy Mohammed Mahdy, Bashir A Fadel, Emad Zarief Kamel, Shimaa Abbas Hassan, Ahmed M. Taha, and Mohamed F Mostafa

Subjects
Male, Portal venous pressure, Digestive System Diseases, Renal function, Hemodynamics, Hemorrhage, Kidney Function Tests, law.invention, lcsh:RD78.3-87.3, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Portal pressure, Double-Blind Method, 030202 anesthesiology, law, medicine, Humans, Vasoconstrictor Agents, Infusions, Intravenous, business.industry, Acute kidney injury, Blood loss, 030208 emergency & critical care medicine, Middle Aged, medicine.disease, Anesthesiology and Pain Medicine, Blood pressure, Mean blood pressure, lcsh:Anesthesiology, Anesthesia, Female, Terlipressin, business, medicine.drug, Research Article
Abstract

Terlipressin, in general, is a vasopressor which acts via V1 receptors. Its infusion elevates mean blood pressure and can reduce bleeding which has a splanchnic origin. The primary outcome was to assess the impact of intraoperative terlipressin infusion on portal venous pressure during hepatobiliary surgery; the 2ry outcomes included effects upon systemic hemodynamics, estimated blood loss, and postoperative renal functions. This prospective randomized study involved 50 patients undergoing hepatobiliary surgery who were randomly and equally allocated into terlipressin group, or a control group. The terlipressin group received an initial bolus dose of (1 mg over 30 min) followed by a continuous infusion of 2 μg/kg/h throughout the procedure and gradually weaned over the first four postoperative hours, whereas the control group received the same volumes of normal saline. The portal venous pressure changes were measured directly through a portal vein angiocatheter. Portal pressure was significantly reduced over time in the terlipressin group only (from 17.88 ± 7.32 to 15.96 ± 6.55 mmHg, p

Published
2019

2. Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy – a secondary analysis of a randomised controlled trial.

Author

Schäfer, Patrick, Fahlenkamp, Astrid, Rossaint, Rolf, Coburn, Mark, and Kowark, Ana

Subjects
*ARTERIES, *BLOOD pressure, *GASES, *HEMODYNAMICS, *ISOFLURANE, *KIDNEY function tests, *NORADRENALINE, *POSTOPERATIVE period, *SURGICAL therapeutics, *SECONDARY analysis, *TREATMENT effectiveness, *NEPHRECTOMY, *CONFOUNDING variables, *INHALATION anesthetics
Abstract

Background: Renal dysfunction following intraoperative arterial hypotension is mainly caused by an insufficient renal blood flow. It is associated with higher mortality and morbidity rates. We hypothesised that the intraoperative haemodynamics are more stable during xenon anaesthesia than during isoflurane anaesthesia in patients undergoing partial nephrectomy. Methods: We performed a secondary analysis of the haemodynamic variables collected during the randomised, single-blinded, single-centre PaNeX study, which analysed the postoperative renal function in 46 patients who underwent partial nephrectomy. The patients received either xenon or isoflurane anaesthesia with 1:1 allocation ratio. We analysed the duration of the intraoperative systolic blood pressure decrease by > 40% from baseline values and the cumulative duration of a mean arterial blood pressure (MAP) of < 65 mmHg as primary outcomes. The secondary outcomes were related to other blood pressure thresholds, the amount of administered norepinephrine, and the analysis of confounding factors on the haemodynamic stability. Results: The periods of an MAP of < 65 mmHg were significantly shorter in the xenon group than in the isoflurane group. The medians [interquartile range] were 0 [0–10.0] and 25.0 [10.0–47.5] minutes, for the xenon and isoflurane group, respectively (P = 0.002). However, the cumulative duration of a systolic blood pressure decrease by > 40% did not significantly differ between the groups (P = 0.51). The periods with a systolic blood pressure decrease by 20% from baseline, MAP decrease to values < 60 mmHg, and the need for norepinephrine, as well as the cumulative dose of norepinephrine were significantly shorter and lower, respectively, in the xenon group. The confounding factors, such as demographic data, surgical technique, or anaesthesia data, were similar in the two groups. Conclusion: The patients undergoing xenon anaesthesia showed a better haemodynamic stability, which might be attributed to the xenon properties. The indirect effect of xenon anaesthesia might be of importance for the preservation of renal function during renal surgery and needs further elaboration. Trial registration: ClinicalTrials.gov: NCT01839084. Registered 24 April 2013. [ABSTRACT FROM AUTHOR]

Published
2019
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3. Usefulness of presepsin in the diagnosis of sepsis in patients with or without acute kidney injury

Author

Takeshi Nishida, Hiroyasu Ishikura, Yoshihiko Nakamura, Reiko Ichiki, Yasumasa Kawano, Akira Murai, and Rie Yuge

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, RIFLE criteria, Lipopolysaccharide Receptors, Renal function, urologic and male genital diseases, Kidney Function Tests, Gastroenterology, Sepsis, Young Adult, Internal medicine, Diagnosis, medicine, Humans, Rifle, Intensive care medicine, Aged, Retrospective Studies, business.industry, urogenital system, Presepsin, Acute kidney injury, Area under the curve, Reproducibility of Results, Retrospective cohort study, Acute Kidney Injury, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Peptide Fragments, Systemic inflammatory response syndrome, Anesthesiology and Pain Medicine, Kidney Failure, Chronic, Female, business, Biomarkers, Kidney disease, Research Article, Glomerular Filtration Rate
Abstract

Background Presepsin is useful for differentiating sepsis from non-infection related systemic inflammatory response syndrome. However, there are no studies investigating the usefulness of presepsin in diagnosing sepsis involving patients with acute kidney injury (AKI). The purpose of this study is to determine levels of blood presepsin in patients with or without sepsis and among non-AKI patients or patients with different degrees of AKI severity. Methods This is a single center retrospective study. 247 patients admitted to the ICU between June 2010 and October 2012 were analyzed for their presepsin levels. We classified the patients into non-AKI and AKI according to the RIFLE (Risk, Injury, Failure, and Loss of kidney function and End-stage kidney disease or simply Loss and ESKD) criteria. We then sub-classified the patients in each group into either non-sepsis or sepsis sub-group and analyzed the accuracy of diagnosing sepsis based on their levels of presepsin. Results The number of patients for each group was: non-AKI, 112; under AKI: Risk, 50; Injury, 36; Failure, 42; Loss and ESKD, 7. The levels of presepsin in sepsis groups were significantly higher than that in the non-sepsis group among the non-AKI, Risk and Injury patients (p

Published
2014

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