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1. Contents Vol. 25, 2007

Author

Anabela Rodrigues, Charn-Ting Wang, Sérgio Aparecido Ignácio, K. Safranow, Jadranka Buturović-Ponikvar, Kazumasa Wakamatsu, António Cabrita, M. Nakamura, Jenq-Wen Huang, Andrzej Breborowicz, Sunanta Areeyakulnimit, K. Ciechanowski, Y. Kobe, Miguel C. Riella, B. Dolegowska, Gunter Wolf, R. Vanholder, H. Schiffl, Elena Mancini, Jacek Karoń, José Carlos Oliveira, Jyh-Chang Hwang, Fernanda Bravo, Reinhold Deppisch, Kuan-Yu Hung, Shosuke Ito, Marc M. H. Hermans, Cees Vermeer, Ilan Ben-Zvi, Onno J. de Boer, Rafael Ponikvar, Ulrike Eismann, Raymond T. Krediet, P. Coratelli, Muriel P.C. Grooteman, G. Glorieux, Christoph C. Haufe, Sonja Zweegman, Shifra Sela, Thananda Trakarnvanich, Stefania Giungi, M. Plantamura, Nicholas A. Hoenich, Kazutaka Murakami, Chih-Chiang Chien, Jakob Gubensek, Sotirios Tsimikas, Alicja Polubinska, Marcelo Távora Mira, D. Quaranta, Mario Traut, Jeroen P. Kooman, Leon J. Schurgers, Antonio Pio Tortorelli, Cleber Machado de Souza, Artur A. Antoniewicz, J. Stepniewska, Suwanna Chabsuwan, Thanit Chirananthavat, Regina Michelis, Dirk R. de Waart, K. Matsuda, Pieter L. Rensma, P. Brescia, Sônia Mara Luczyszyn, Satoshi Sugiyama, J. Bober, Elizabeth R. Miller, Menso J. Nubé, Antonio Di Felice, Günter Stein, Andre A. Kaplan, Pakamas Maneerat, Giovanna Luciani, I. Devolder, Markus Ketteler, Abel Thijs, Sandra Silva, Andréa Rodrigues Ávila, Rui Barbosa de Brito, Roos van Westrhenen, Peter C. Huijgens, Ulrich Gladziwa, Edward B. Lin, Isabel Fonseca, R. Ria, Esther Merki, H. Hirasawa, Luigi Tazza, Cindy Kunne, S. Oda, Hiroki Takahashi, Vincent Brandenburg, B. Millo, Christian Probst, S. Van Laecke, D. Chlubek, Rafael M. Nagler, Ana Paula Ribeiro Braosi, Katarzyna Sumińska-Jasińska, Antonio Santoro, Najat Hajji, A. Ramunni, Paula Cristina Trevilatto, Coen D.A. Stehouwer, Vanessa Santos Sotomaior, Yukiko Nakanishi, Jan Aten, Emanuele Mambelli, Karel M.L. Leunissen, Roberto Pecoits-Filho, Maurizio Bossola, and Silvia Casanova

Subjects
Nephrology, Hematology, General Medicine
Published
2007
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2. Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat

Author

Najat Hajji, Jan Aten, Roos van Westrhenen, Onno J. de Boer, Dirk R. de Waart, Raymond T. Krediet, Cindy Kunne, AII - Amsterdam institute for Infection and Immunity, Pathology, Other departments, ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Tytgat Institute for Liver and Intestinal Research, and Nephrology

Subjects
Male, Angiogenesis, medicine.medical_treatment, Pharmacology, Peritoneal Diseases, Peritoneal dialysis, Fibrosis, Cyclosporin a, medicine, Animals, Lactic Acid, Rats, Wistar, Peritoneal Fibrosis, Dialysis, Neovascularization, Pathologic, business.industry, Hematology, General Medicine, Ciclosporin, medicine.disease, Hemodialysis Solutions, Rats, Glucose, Nephrology, Immunology, Cyclosporine, Hemodialysis, business, Peritoneal Dialysis, medicine.drug
Abstract

Background/Aims: Cyclosporin A (CsA) stimulates the development of fibrosis. We investigated whether CsA contributes to peritoneal alterations induced by long-term exposure to dialysis solutions. Methods: Ten rats received peritoneal infusion of dialysis solution and oral CsA for 8 weeks. Eight received only the dialysis solution (controls). Peritoneal function was assessed at 8 weeks followed by sacrifice. The number of vessels was counted, fibrosis was assessed and hydroxyproline was determined. PCR was performed for vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β). Results: Histology revealed more fibrosis, hydroxyproline and vessels (thick walled) in CsA-exposed animals. Peritoneal transport was not different. The mRNA content of TGF-β, CTGF and VEGF was higher in CsA. Conclusion: CsA combined with exposure to dialysis solutions was associated with increased peritoneal fibrosis and angiogenesis.

Published
2007
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3. Subject Index Vol. 25, 2007

Author

Kazumasa Wakamatsu, Onno J. de Boer, Pieter L. Rensma, P. Brescia, K. Ciechanowski, Sonja Zweegman, P. Coratelli, Gunter Wolf, Satoshi Sugiyama, R. Vanholder, Kazutaka Murakami, Fernanda Bravo, Jacek Karoń, Ilan Ben-Zvi, G. Glorieux, Jeroen P. Kooman, Marc M. H. Hermans, Esther Merki, Antonio Di Felice, Shosuke Ito, Rafael Ponikvar, Shifra Sela, Mario Traut, Andrzej Breborowicz, Alicja Polubinska, Antonio Santoro, Ulrike Eismann, Suwanna Chabsuwan, Ana Paula Ribeiro Braosi, M. Plantamura, Rui Barbosa de Brito, Anabela Rodrigues, Giovanna Luciani, M. Nakamura, Roos van Westrhenen, H. Schiffl, H. Hirasawa, Jenq-Wen Huang, Luigi Tazza, D. Quaranta, Günter Stein, Peter C. Huijgens, Rafael M. Nagler, Katarzyna Sumińska-Jasińska, Charn-Ting Wang, Miguel C. Riella, Andre A. Kaplan, K. Safranow, Christoph C. Haufe, Sônia Mara Luczyszyn, Ulrich Gladziwa, Edward B. Lin, Cleber Machado de Souza, Elena Mancini, Y. Kobe, Sotirios Tsimikas, Emanuele Mambelli, José Carlos Oliveira, Thananda Trakarnvanich, Chih-Chiang Chien, Karel M.L. Leunissen, Stefania Giungi, Reinhold Deppisch, Kuan-Yu Hung, Roberto Pecoits-Filho, Isabel Fonseca, R. Ria, Elizabeth R. Miller, Raymond T. Krediet, Leon J. Schurgers, Antonio Pio Tortorelli, Cindy Kunne, B. Millo, J. Bober, Pakamas Maneerat, Christian Probst, S. Oda, Artur A. Antoniewicz, Sandra Silva, Coen D.A. Stehouwer, Markus Ketteler, Sérgio Aparecido Ignácio, Jakob Gubensek, Vanessa Santos Sotomaior, S. Van Laecke, Hiroki Takahashi, Andréa Rodrigues Ávila, Yukiko Nakanishi, António Cabrita, Jan Aten, B. Dolegowska, Maurizio Bossola, Thanit Chirananthavat, Dirk R. de Waart, Regina Michelis, K. Matsuda, Nicholas A. Hoenich, Jyh-Chang Hwang, Cees Vermeer, Muriel P.C. Grooteman, Jadranka Buturović-Ponikvar, Sunanta Areeyakulnimit, D. Chlubek, Najat Hajji, A. Ramunni, Paula Cristina Trevilatto, Vincent Brandenburg, Marcelo Távora Mira, J. Stepniewska, Menso J. Nubé, I. Devolder, Abel Thijs, and Silvia Casanova

Subjects
Index (economics), Nephrology, Statistics, Subject (documents), Hematology, General Medicine, Mathematics
Published
2007
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4. Cyclosporin A Induces Peritoneal Fibrosis and Angiogenesis during Chronic Peritoneal Exposure to a Glucose-Based, Lactate-Buffered Dialysis Solution in the Rat.

Author

Roos van Westrhenen, Jan Aten, Najat Hajji, Onno J. de Boer, Cindy Kunne, Dirk R. de Waart, and Raymond T. Krediet

Subjects
CYCLOSPORINE, FIBROSIS, DIALYSIS (Chemistry), LABORATORY rats, GROWTH factors, MESSENGER RNA, NEOVASCULARIZATION
Abstract

Background/Aims: Cyclosporin A (CsA) stimulates the development of fibrosis. We investigated whether CsA contributes to peritoneal alterations induced by long-term exposure to dialysis solutions. Methods: Ten rats received peritoneal infusion of dialysis solution and oral CsA for 8 weeks. Eight received only the dialysis solution (controls). Peritoneal function was assessed at 8 weeks followed by sacrifice. The number of vessels was counted, fibrosis was assessed and hydroxyproline was determined. PCR was performed for vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β). Results: Histology revealed more fibrosis, hydroxyproline and vessels (thick walled) in CsA-exposed animals. Peritoneal transport was not different. The mRNA content of TGF-β, CTGF and VEGF was higher in CsA. Conclusion: CsA combined with exposure to dialysis solutions was associated with increased peritoneal fibrosis and angiogenesis. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2007
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