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3 results on '"Natascha J. H. Broers"'

1. Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

Author

Paul Brenchley, Frank M. van der Sande, Nicos Mitsides, Nanda M. P. Diederen, Jeroen P. Kooman, Sandip Mitra, Tom Cornelis, Natascha J. H. Broers, Casper G. Schalkwijk, Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: CCZ Hemodialyse (9), MUMC+: MA Nefrologie (9), and RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome

Subjects
Male, Time Factors, GLYCOCALYX, medicine.medical_treatment, 030232 urology & nephrology, Blood Pressure, 030204 cardiovascular system & hematology, DISEASE, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Longitudinal Studies, Pulse wave velocity, education.field_of_study, NOCTURNAL HOME HEMODIALYSIS, Hematology, General Medicine, Middle Aged, Cardiovascular physiology, Extended dialysis, Nephrology, Cardiology, SURVIVAL, Biomarker (medicine), Female, Adult, medicine.medical_specialty, Ambulatory blood pressure, Population, Pulse Wave Analysis, 03 medical and health sciences, Renal Dialysis, Internal medicine, medicine, ENDOTHELIAL SURFACE-LAYER, Humans, education, Dialysis, Aged, Inflammation, CONVENTIONAL HEMODIALYSIS, business.industry, medicine.disease, Comorbidity, DIALYSIS PATIENTS, RANDOMIZED-CONTROLLED-TRIAL, business, Biomarkers
Abstract

Background: Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. Methods: We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark-field capillaroscopy and vascular biomarkers. Results: EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Biomarker profiles were similar in EHD and CHD but abnormal compared to healthy controls. Conclusion: Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias.

Published
2017

2. Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer

Author

Frank M. van der Sande, Rene van Oerle, Jeroen P. Kooman, Hans Vink, Tom Cornelis, Hugo ten Cate, Natascha J. H. Broers, Denise C. L. M. Titulaer, Yvonne M. C. Henskens, Henri M. H. Spronk, Karel M.L. Leunissen, Interne Geneeskunde, Promovendi NTM, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA CDL Algemeen (9), MUMC+: DA CDL Analytisch cluster 1K (9), Biochemie, Fysiologie, MUMC+: MA Nefrologie (9), MUMC+: MA Alg Interne Geneeskunde (9), RS: CARIM - R1 - Thrombosis and haemostasis, RS: CARIM - R3 - Vascular biology, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
Male, CHRONIC KIDNEY-DISEASE, GLYCOCALYX, medicine.medical_treatment, MPV, Endothelial surface layer, End-stage renal disease, Dialysis Solutions, DIALYSIS, Platelet, Aged, 80 and over, Microscopy, SHEAR-STRESS, Nadroparin, Hematology, General Medicine, ASSOCIATION, Middle Aged, Intercellular Adhesion Molecule-1, P-Selectin, medicine.anatomical_structure, Nephrology, Hemodialysis, Hemoglobinometry, Female, E-Selectin, SOLUBLE P-SELECTIN, Mean Platelet Volume, CELL-ADHESION, medicine.medical_specialty, Endothelium, medicine.drug_class, Point-of-Care Systems, Vascular Cell Adhesion Molecule-1, Low molecular weight heparin, Sampling Studies, End stage renal disease, Renal Dialysis, Internal medicine, medicine, Humans, Platelet activation, Renal Insufficiency, Chronic, Mean platelet volume, Mouth Floor, Dialysis, Aged, GLYCOSAMINOGLYCANS, business.industry, Microcirculation, Anticoagulants, Endocrinology, Immunology, Endothelium, Vascular, Syndecan-1, CHRONIC-RENAL-FAILURE, business, Adhesion molecules, SULFATE
Abstract

Background: Chronic kidney disease patients show changes in the endothelial surface layer (ESL). Whether hemodialysis (HD) itself or low molecular weight heparins (LMWH) induce ESL alterations is unknown. Methods: We studied the ESL in 20 HD patients with Sidestream Dark Field Imaging [measuring perfused boundary region (PBR)] and measurement of ESL constituents in plasma during HD in 2 studies. LMWH was administered at the start of HD in study A, and 120 min after the start of HD in study B. Mean platelet volume (MPV) and platelet large cell ratio (P-LCR) were also measured. Results: Syndecan-1 increased significantly 30 min after LMWH administration. sP-Selectin increased 120 min after HD start, and MPV and P-LCR decreased significantly during HD. No significant changes of PBR, sE-Selectin, sICAM-1, or sVCAM-1 were perceived. Conclusions: HD caused a significant increase in Syndecan-1 without a change in PBR. The administration of LMWH appeared to precede the rise in Syndecan-1.

Published
2014
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3. Contents Vol. 38, 2014

Author

Kathleen D. Liu, Jose J. Zaragoza, Shouichi Fujimoto, Jacob M. Kesner, Maria Grazia D'Alfonso, Sajja Tatiyanupanwong, Roberta Russo, Su-Juan Feng, Paola Di Maggio, Aashish Sharma, Joseph Michael Yardman-Frank, Pisith Intarawongchot, Ammrit Suwattanasin, Yuji Sato, Sarah Rudolf, Han Li, Marco Mendes, Hidetoshi Shiga, Michelle A. Barron, David Navarro, Craig S. Wong, Til Leimbach, Liliana Gonzalez-Espinoza, Tiago Amaral, Nobuo Fuke, Hugo ten Cate, Denise C. L. M. Titulaer, Kunihiro Mashiko, Laksamon Praderm, Margherita Berardi, Daniel Schneditz, Emilio González-Parra, Michael Zakharchenko, Cosimo Chelazzi, Andrea Memoli, Henri M. H. Spronk, Gian Franco Gensini, Helena Brodska, Benjamin Koch, Satz Mengensatzproduktion, Valeria Sainz-Prestel, María Dolores Arenas, Ivo Laranjinha, María Luisa González-Casaus, Tilo Freiwald, Dhavee Sirivongs, Michael Heung, Jeroen P. Kooman, Immacolata Daniela Maresca, Bruno Memoli, Surapong Narenpitak, Martin Balik, Kazuo Kitamura, Cholatip Pongskul, Hiroyuki Hirasawa, Olga Dolnik, Mauro Neri, Anna Caldini, Alberto Ortiz, Stephan Becker, Tom Cornelis, Shi-Xiang Wang, Jay L. Koyner, Druckerei Stückle, Nobuya Kitamura, Aloun Mary Vilay, Maurizio Sodo, Sirirat Anutrakulchai, Stefan Büttner, Yoshihiko Kikuchi, Jan Rulisek, Gianluca Villa, Pakorn Tungkasereerak, Jesús Egido, Sabine Aign, Inês Aires, Miguel Angel Muñoz-Rodriguez, Kenich Matsuda, Susanne Kron, Mario Cozzolino, Ana Paula Azevedo, Jürgen Engel, Martin Stritesky, Somnuek Domrongkitchaiporn, Gennaro Argentino, Osamu Nishida, Karel M.L. Leunissen, Sarah Faubel, Jirasak Anukulanantachai, Masataka Nakamura, Cristina Jorge, Ammar Tabikh, Tatsunori Toida, Markus Eickmann, Kannika Niwattayakul, Célia Gil, Bandit Thinkhamrop, Patrícia Matias, Hans Vink, Pavel Leden, Renee-Claude Mercier, Frank M. van der Sande, Aníbal Ferreira, Rene van Oerle, Norihiko Shibata, Helmut Geiger, Shigeto Oda, Claudio Ronco, Michal Otahal, Serafina Valente, Michael J. Connor, Luigi Celentano, Thathsalang Keobounma, Scott E. Walker, Harold A. Franch, A. Raffaele De Gaudio, Dean P. Argyres, Anitha Vijayan, Tommasina Strazzullo, Chavasak Kanokkantapong, Yvonne M. C. Henskens, Joachim Kron, Gui-Zhi Zhang, Thanachai Panaput, Carina Ferreira, and Natascha J. H. Broers

Subjects
Nephrology, Hematology, General Medicine
Published
2014
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