6 results on '"Borrelli S"'
Search Results
2. Effect of Increased Convection Volume by Mid-Dilution Hemodiafiltration on the Subclinical Chronic Inflammation in Maintenance Hemodialysis Patients
- Author
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Walter De Simone, Roberto Minutolo, Giuseppe Conte, Luca De Nicola, Emanuele De Simone, Carlo Garofalo, Silvio Borrelli, Michele Provenzano, Borrelli, S, Minutolo, R, De Nicola, L, Conte, G, and Garofalo, C
- Subjects
Male ,medicine.medical_specialty ,030232 urology & nephrology ,Inflammation ,Hemodiafiltration ,030204 cardiovascular system & hematology ,Systemic inflammation ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Subclinical infection ,Aged ,Cross-Over Studies ,business.industry ,Albumin ,Hematology ,General Medicine ,Maintenance hemodialysis ,Blood Proteins ,Middle Aged ,Mid-dilution ,Crossover study ,Dilution ,Volume (thermodynamics) ,Nephrology ,Chronic Disease ,Female ,medicine.symptom ,business - Abstract
Mid-dilution hemodiafiltration (MID) is a dialytic technique that might improve systemic inflammation of patients in chronic hemodialysis (HD) by increasing substitution volumes. To verify this hypothesis, we performed a prospective cross-over study comparing the effect on inflammatory biomarkers of higher convection by MID versus standard convection by post-dilution hemodiafiltration (HDF). Patients under chronic HD were therefore treated by MID and HDF by crossover design. Each treatment period lasted 4 months, with 1 month of wash-out where patients were treated by HD, for a total of 9 months. Primary outcome was the change of serum pre-dialytic C-Reactive Protein (CRP), interleukin 6 (IL-6), IL-1, IL-10, transforming growth factor-β (TGF-β), tumor necrosis factor-α, albumin and pre-albumin. Samples were obtained monthly. Ten HD patients were enrolled (age: 64.9 ± 12.6 years; 70% males; dialytic vintage: 10.6 [2.7–16.2] years). Mean convection volume was 40.1 ± 2.5 L/session in MID and 20.1 ± 2.6 L/session in HDF. A significant reduction of β2-Microglobulin was detected as a result of either treatment. In MID, CRP decreased from 11.3 (3.2–31.0) to 3.1 (1.4–14.4) mg/L (p = 0.007), IL-6 from 12.7 (5.0–29.7) to 8.3 (4.4–14.0) pg/mL (p = 0.003), and TGF-β from 10.6 (7.4–15.6) to 7.4 (5.9–9.3) ng/mL (p = 0.001). A significant reduction of CRP from 8.5 (3.2–31.0) to 4.6 (3.2–31.0) mg/L was also detected in HDF (p = 0.037), whereas no significant reduction of IL-6 (p = 0.147) and TGF-β (p = 0.094) was found. Percentage reduction of IL-6 correlated with mean convective volume in HDF (R = 0.666; p = 0.036) and in MID (R = 0.760; p = 0.020). Therefore, MID and HDF are associated with an attenuation of inflammatory pattern that is correlated with a high convective volume.
- Published
- 2018
3. Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration
- Author
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Giuseppe Conte, Ludovica D'Apice, Silvio Borrelli, Raffaele Genualdo, Olga Credendino, L. De Nicola, G Iacono, A Sarti, B Zito, Pasquale Zamboli, Pasquale Guastaferro, Maria Rita Auricchio, V Apperti, Filippo Nigro, A De Paola, A Di Serafino, Caterina Saviano, Maria Capuano, Carmela Iodice, M Merola, E De Simone, Roberto Minutolo, G Iulianiello, Borrelli, S, Minutolo, Roberto, DE NICOLA, Luca, Zamboli, Pasquale, Iodice, C, DE PAOLA, A, DE SIMONE, E, Zito, B, Guastaferro, P, Nigro, F, Apperti, V, Iulianiello, G, Credendino, O, Iacono, G, DI SERAFINO, A, D'Apice, L, Saviano, C, Sarti, A, Capuano, M, Genualdo, R, Auricchio, M, Merola, M, and Conte, Giuseppe
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Endogeny ,Hemodiafiltration ,Renal Dialysis ,Internal medicine ,Diabetes mellitus ,Hfr cell ,medicine ,Humans ,Acetate-Free Biofiltration ,Amino Acids ,Dialysis ,Aged ,chemistry.chemical_classification ,Chemistry ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Plasma amino acid levels ,Hemodialysis Solutions ,Amino acid ,Endocrinology ,Cross-Sectional Studies ,Biochemistry ,Nephrology ,Hemodialysis - Abstract
During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1:1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (µmol/l) of total AA (3,176 ± 722), essential AA (889 ± 221), and branched chain AA (459 ± 140) levels in HFR were similar to those in AFB (3,399 ± 621, 938 ± 277, and 463 ± 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood.
- Published
- 2010
4. Effect of Increased Convection Volume by Mid-Dilution Hemodiafiltration on the Subclinical Chronic Inflammation in Maintenance Hemodialysis Patients.
- Author
-
Borrelli S, Minutolo R, De Simone E, De Simone W, Provenzano M, De Nicola L, Conte G, and Garofalo C
- Subjects
- Aged, Chronic Disease, Cross-Over Studies, Female, Humans, Inflammation blood, Inflammation therapy, Male, Middle Aged, Blood Proteins metabolism, Hemodiafiltration
- Abstract
Mid-dilution hemodiafiltration (MID) is a dialytic technique that might improve systemic inflammation of patients in chronic hemodialysis (HD) by increasing substitution volumes. To verify this hypothesis, we performed a prospective cross-over study comparing the effect on inflammatory biomarkers of higher convection by MID versus standard convection by post-dilution hemodiafiltration (HDF). Patients under chronic HD were therefore treated by MID and HDF by crossover design. Each treatment period lasted 4 months, with 1 month of wash-out where patients were treated by HD, for a total of 9 months. Primary outcome was the change of serum pre-dialytic C-Reactive Protein (CRP), interleukin 6 (IL-6), IL-1, IL-10, transforming growth factor-β (TGF-β), tumor necrosis factor-α, albumin and pre-albumin. Samples were obtained monthly. Ten HD patients were enrolled (age: 64.9 ± 12.6 years; 70% males; dialytic vintage: 10.6 [2.7-16.2] years). Mean convection volume was 40.1 ± 2.5 L/session in MID and 20.1 ± 2.6 L/session in HDF. A significant reduction of β2-Microglobulin was detected as a result of either treatment. In MID, CRP decreased from 11.3 (3.2-31.0) to 3.1 (1.4-14.4) mg/L (p = 0.007), IL-6 from 12.7 (5.0-29.7) to 8.3 (4.4-14.0) pg/mL (p = 0.003), and TGF-β from 10.6 (7.4-15.6) to 7.4 (5.9-9.3) ng/mL (p = 0.001). A significant reduction of CRP from 8.5 (3.2-31.0) to 4.6 (3.2-31.0) mg/L was also detected in HDF (p = 0.037), whereas no significant reduction of IL-6 (p = 0.147) and TGF-β (p = 0.094) was found. Percentage reduction of IL-6 correlated with mean convective volume in HDF (R = 0.666; p = 0.036) and in MID (R = 0.760; p = 0.020). Therefore, MID and HDF are associated with an attenuation of inflammatory pattern that is correlated with a high convective volume., (© 2018 S. Karger AG, Basel.)
- Published
- 2019
- Full Text
- View/download PDF
5. Dialysis-Related Acidemia and Acidosis by Dialysate: The Forgotten Issue of CO2 Overload from Dialysate.
- Author
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Marano M, Borrelli S, and Zamboli P
- Subjects
- Acid-Base Equilibrium drug effects, Acidosis blood, Acidosis etiology, Acidosis physiopathology, Bicarbonates administration & dosage, Carbon Dioxide administration & dosage, Dyspnea blood, Dyspnea etiology, Dyspnea physiopathology, Hemodialysis Solutions administration & dosage, Hydrogen-Ion Concentration, Hypercapnia blood, Hypercapnia etiology, Hypercapnia physiopathology, Hypoxia blood, Hypoxia etiology, Hypoxia physiopathology, Kidney Failure, Chronic blood, Kidney Failure, Chronic physiopathology, Rheology, Vasodilation drug effects, Bicarbonates adverse effects, Carbon Dioxide adverse effects, Hemodialysis Solutions adverse effects, Kidney Failure, Chronic therapy, Renal Dialysis adverse effects
- Published
- 2016
- Full Text
- View/download PDF
6. pCO2 Reveals Arteriovenous Fistula Recirculation in Bicarbonate Hemodialysis (RecirCO2lation Test).
- Author
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Marano M, Borrelli S, and Zamboli P
- Subjects
- Aged, Aged, 80 and over, Area Under Curve, Arteriovenous Fistula physiopathology, Biomarkers blood, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Monitoring, Physiologic, Predictive Value of Tests, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic pathology, Vascular Access Devices, Arteriovenous Fistula diagnosis, Bicarbonates therapeutic use, Carbon Dioxide blood, Renal Dialysis, Renal Insufficiency, Chronic therapy
- Abstract
We propose arterial pCO2 as test to discover vascular access recirculation (VAR) in bicarbonate hemodialysis (HD). We selected 30 HD patients with a ascertained well-functioning arteriovenous fistula (Control). In these patients, we artificially created VAR through the reversion of HD lines (Reversed). Results of the arterial gas analysis were collected at the start of HD (baseline) and after 5 min. At baseline, no differences of pH, pCO2 and HCO3 were found between the 2 groups. At 5 min, pCO2 increased from 38.1 ± 3.3 to 47.2 ± 6.3 mm Hg (p < 0.0001) in Reversed, whereas no increase was found in Control (p = 0.052). Areas under curve of pCO2-increase was 0.96 (0.91-1.00) and pCO2 at 5 min 0.92 (0.85-0.98). pCO2-increase >4.5 mm Hg showed sensitivity 86.7% and specificity 100% with positive predictive value (PPV) 100% and negative predictive value (NPV) 89%. A pCO2 value above 43 mm Hg at 5 min showed sensitivity 80%, specificity 90%, PPV 89%, NPV 82%. pCO2 increase >4.5 mm Hg and/or pCO2 at 5 min >43 mm Hg may accurately detect VAR., (© 2015 S. Karger AG, Basel.)
- Published
- 2016
- Full Text
- View/download PDF
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