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8. Blood pressure target in patients with hypertension and type-2 diabetes older than 65 years. Is <130/80 mmHg the right target or an excessive objective preventing from achieving the clinical goals we are aiming at?

11. The International Society of Hypertension Guidelines 2020 - a new drug treatment recommendation in the wrong direction?

12. Intensive systolic blood pressure control and prevention of new onset atrial fibrillation in the SPRINT study: is the association really controversial?

14. How to deal with the occurrence of rare drug-induced adverse events: the example of sprue-like enteropathy induced by olmesartan medoxomil and other angiotensin-receptor blockers.

16. Systolic blood pressure control prevents cognitive decline and slows development of white matter lesions in the brain: the SPRINT MIND study outcomes.

18. The PARAGON Heart Failure trial - ongoing investigation of the angiotensin receptor antagonist/neprilysin inhibitor sacubitril/valsartan in heart failure patients with hypertension and preserved ejection fraction.

19. Need for multiple risk reduction strategies in clinical trials enrolling high risk patients - FOURIER investigating PCSK-9 inhibitor to lower cholesterol revisited.

23. Intensive blood pressure lowering prevents mild cognitive impairment and possible dementia and slows development of white matter lesions in brain: the SPRINT Memory and Cognition IN Decreased Hypertension (SPRINT MIND) study.

24. Renal denervation achieved by endovascular delivery of ultrasound in RADIANCE-HTN SOLO or by radiofrequency energy in SPYRAL HTN-OFF and SPYRAL-ON lowers blood pressure.

28. Treatment strategies for comorbid conditions lower residual risk in patients with treated hypertension: FOURIER and other randomized outcome trials.

33. The polypill: an emerging treatment alternative for secondary prevention of cardiovascular disease.

34. The J-curve phenomenon revisited again: SPRINT outcomes favor target systolic blood pressure below 120 mmHg.

41. Angiotensin receptor--neprilysin inhibiton (ARNI)--a novel therapeutic concept for management of hypertension and heart failure.

42. Direct renin inhibitors in hypertension - approaching the moment of truth.

43. Increased time varying heart rate and cardiovascular risk in hypertension: benefit of selective I((f)) channel inhibitor?

44. An appropriate SCORE to assess cardiovascular risk in hypertension?

45. Renal nerve ablation: emerging role in therapeutics.

47. Antihypertensive therapy and cancer risks?

48. Treatment of high blood pressure in acute stroke--the SCAST study.

49. Cardiovascular risks in HIV patients.

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