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Start Over Author "Anupam Banerjee" Journal blood advances
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2. YY1 controls Eμ-3′RR DNA loop formation and immunoglobulin heavy chain class switch recombination

Author

Michael L. Atchison, Corbett T. Berry, Falon Gray, Tatiana I. Gerasimova, Anupam Banerjee, Vishal J. Sindhava, Ranjan Sen, Arindam Basu, Vibha Jha, and Parul Mehra

Subjects
0301 basic medicine, YY1, Effector, Immunoglobulin Isotypes, chemical and pharmacologic phenomena, Hematology, Biology, Stimulus Report, Molecular biology, Loop (topology), 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Immunoglobulin class switching, chemistry, Dna breaks, embryonic structures, Immunoglobulin heavy chain, DNA
Abstract

Key Points Transcription factor YY1 regulates the IgH Eμ-3′RR long-distance DNA loop without the YY1 transcriptional activation domain. YY1 constructs that rescue the Eμ-3′RR DNA loop also restore CSR strongly arguing for the necessity of this long-distance DNA loop for CSR.

Published
2016

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