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18 results on '"van Leeuwen, Flora E."'

2. Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma

Author

Opstal-van Winden, Annemieke W.J., de Haan, Hugoline G., Hauptmann, Michael, Schmidt, Marjanka K., Broeks, Annegien, Russell, Nicola S., Janus, Cécile P.M., Krol, Augustinus D.G., van der Baan, Frederieke H., De Bruin, Marie L., van Eggermond, Anna M., Dennis, Joe, Anton-Culver, Hoda, Haiman, Christopher A., Sawyer, Elinor J., Cox, Angela, Devilee, Peter, Hooning, Maartje J., Peto, Julian, Couch, Fergus J., Pharoah, Paul, Orr, Nick, Easton, Douglas F., Aleman, Berthe M.P., Strong, Louise C., Bhatia, Smita, Cooke, Rosie, Robison, Leslie L., Swerdlow, Anthony J., and van Leeuwen, Flora E.

Published
2019
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3. Risk of male breast cancer after Hodgkin lymphoma

Author

de Vries, Simone, primary, Krul, Inge M., additional, Schaapveld, Michael, additional, Janus, Cecile P. M., additional, Rademakers, Saskia E., additional, Roesink, Judith M., additional, Nijziel, Marten R., additional, Bilgin, Yavuz M., additional, Aleman, Berthe M. P., additional, and van Leeuwen, Flora E., additional

Published
2023
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5. Risk of male breast cancer after Hodgkin lymphoma

Author

van Leeuwen, F. E., Nijdam, A., Aleman, B. M. P., de Boer, J. P., Janus, C. P. M., Mutsaers, P. G. N. J., So-Osman, C., Zijlstra, J. M., Meijer, O. W. M., Rademakers, S. E., Krol, A. D. G., Kersten, M. J., Tonino, S. H., Jalink, M., Daniëls, L. A., van Spronsen, D. J., van der Maazen, R. W. M., Loonen, J., Roesink, J. M., Oostvogels, R., de Weijer, R., Buter, D., de Boer, A., Aarsman, K. M., Oudbier, C. W., Nijziel, M. R., van den Berg, M., Verschueren, K., Schippers, M., Boersma, R. S., Issa, D. E., Plattel, W. J., Stedema, F. G., Koene, H. R., Raymakers, E. R. P. M., Schimmel, E., van Hezewijk, M., Bouma, P., Muller, K., Siemes, C., van der Spek, J. M., Ong, F., Jonkman, A., de Jongh, E., Sprangers, S., Kortleve, J. P., Vermeiden, C. M., Ta, B., Vercoulen, L., Paulissen, J., Posthuma, E. F. M., Brouwer, R. E., Soechit, S., van der Wiel, M., Böhmer, L., Bilgin, M. Y., Kuipers, S., Houmes, M., te Boome, L., Gommers, S., de Vries, Simone, Krul, Inge M., Schaapveld, Michael, Janus, Cecile P. M., Rademakers, Saskia E., Roesink, Judith M., Nijziel, Marten R., Bilgin, Yavuz M., Aleman, Berthe M. P., and van Leeuwen, Flora E.

Published
2023
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7. Increased prevalence of BRCA1/2 mutations in women with macrotextured breast implants and anaplastic large cell lymphoma of the breast

Author

de Boer, Mintsje, primary, Hauptmann, Michael, additional, Hijmering, Nathalie J., additional, van Noesel, Carel J. M., additional, Rakhorst, Hinne A., additional, Meijers-Heijboer, Hanne E. J., additional, de Boer, Jan Paul, additional, van der Hulst, René R. W. J., additional, de Jong, Daphne, additional, and van Leeuwen, Flora E., additional

Published
2020
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9. Risk of male breast cancer after Hodgkin lymphoma

Author

de Vries, Simone, Krul, Inge M., Schaapveld, Michael, Janus, Cecile P. M., Rademakers, Saskia E., Roesink, Judith M., Nijziel, Marten R., Bilgin, Yavuz M., van Leeuwen, F. E., Nijdam, A., Aleman, B. M. P., de Boer, J. P., Janus, C. P. M., Mutsaers, P. G. N. J., So-Osman, C., Zijlstra, J. M., Meijer, O. W. M., Rademakers, S. E., Krol, A. D. G., Kersten, M. J., Tonino, S. H., Jalink, M., Daniëls, L. A., van Spronsen, D. J., van der Maazen, R. W. M., Loonen, J., Roesink, J. M., Oostvogels, R., de Weijer, R., Buter, D., de Boer, A., Aarsman, K. M., Oudbier, C. W., Nijziel, M. R., van den Berg, M., Verschueren, K., Schippers, M., Boersma, R. S., Issa, D. E., Plattel, W. J., Stedema, F. G., Koene, H. R., Raymakers, E. R. P. M., Schimmel, E., van Hezewijk, M., Bouma, P., Muller, K., Siemes, C., van der Spek, J. M., Ong, F., Jonkman, A., de Jongh, E., Sprangers, S., Kortleve, J. P., Vermeiden, C. M., Ta, B., Vercoulen, L., Paulissen, J., Posthuma, E. F. M., Brouwer, R. E., Soechit, S., van der Wiel, M., Böhmer, L., Bilgin, M. Y., Kuipers, S., Houmes, M., te Boome, L., Gommers, S., Aleman, Berthe M. P., and van Leeuwen, Flora E.

Abstract

•Male survivors of HL treated with chest radiotherapy have an increased risk of developing BC compared with the general population.•Although the occurrence of male BC is an uncommon event, clinicians should be alert to BC symptoms in male survivors of HL.

Published
2024
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11. Risk of multiple primary malignancies following treatment of Hodgkin lymphoma

Author

van Eggermond, Anna M., primary, Schaapveld, Michael, additional, Lugtenburg, Pieternella J., additional, Krol, Augustinus D. G., additional, de Boer, Jan Paul, additional, Zijlstra, Josée M., additional, Raemaekers, John M. M., additional, Kremer, Leontien C. M., additional, Roesink, Judith M., additional, Louwman, Marieke W. J., additional, Aleman, Berthe M. P., additional, and van Leeuwen, Flora E., additional

Published
2014
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13. FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

Author

Ma, Yussanne P., primary, van Leeuwen, Flora E., additional, Cooke, Rosie, additional, Broeks, Annegien, additional, Enciso-Mora, Victor, additional, Olver, Bianca, additional, Lloyd, Amy, additional, Broderick, Peter, additional, Russell, Nicola S., additional, Janus, Cecile, additional, Ashworth, Alan, additional, Houlston, Richard S., additional, and Swerdlow, Anthony J., additional

Published
2012
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14. Risk of Treatment-Related Stomach Cancer Among Hodgkin Lymphoma Survivors

Author

Morton, Lindsay M., primary, Gilbert, Ethel S., additional, Lynch, Charles F., additional, Hall, Per, additional, Dores, Graca M., additional, Curtis, Rochelle E., additional, Storm, Hans H., additional, Johannesen, Tom Borge, additional, Stovall, Marilyn, additional, Smith, Susan A., additional, Weathers, Rita E., additional, Aleman, Berthe M., additional, Kleinerman, Ruth A., additional, Fraumeni, Joseph F., additional, Holowaty, Eric J., additional, Pukkala, Eero, additional, Kaijser, Magnus, additional, Hauptmann, Michael, additional, Fossa, Sophie D., additional, Joensuu, Heikki, additional, Andersson, Michael, additional, Belt-Dusebout, Alexandra W. van den, additional, Vaalavirta, Leila, additional, Langmark, Froydis, additional, Travis, Lois B., additional, and van Leeuwen, Flora E., additional

Published
2010
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15. Late cardiotoxicity after treatment for Hodgkin lymphoma

Author

Aleman, Berthe M. P., primary, van den Belt-Dusebout, Alexandra W., additional, De Bruin, Marie L., additional, van 't Veer, Mars B., additional, Baaijens, Margreet H. A., additional, Boer, Jan Paul de, additional, Hart, Augustinus A. M., additional, Klokman, Willem J., additional, Kuenen, Marianne A., additional, Ouwens, Gabey M., additional, Bartelink, Harry, additional, and van Leeuwen, Flora E., additional

Published
2006
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16. Late cardiotoxicity after treatment for Hodgkin lymphoma

Author

Aleman, Berthe M. P., van den Belt-Dusebout, Alexandra W., De Bruin, Marie L., van 't Veer, Mars B., Baaijens, Margreet H. A., Boer, Jan Paul de, Hart, Augustinus A. M., Klokman, Willem J., Kuenen, Marianne A., Ouwens, Gabey M., Bartelink, Harry, and van Leeuwen, Flora E.

Abstract

We assessed cardiovascular disease (CVD) incidence in 1474 survivors of Hodgkin lymphoma (HL) younger than 41 years at treatment (1965-1995). Multivariable Cox regression and competing risk analyses were used to quantify treatment effects on CVD risk. After a median follow-up of 18.7 years, risks of myocardial infarction (MI) and congestive heart failure (CHF) were strongly increased compared with the general population (standardized incidence ratios [SIRs] = 3.6 and 4.9, respectively), resulting in 35.7 excess cases of MI and 25.6 excess cases of CHF per 10 000 patients/year. SIRs of all CVDs combined remained increased for at least 25 years and were more strongly elevated in younger patients. Mediastinal radiotherapy significantly increased the risks of MI, angina pectoris, CHF, and valvular disorders (2- to 7-fold). Anthracyclines significantly added to the elevated risks of CHF and valvular disorders from mediastinal RT (hazard ratios [HRs] were 2.81 and 2.10, respectively). The 25-year cumulative incidence of CHF after mediastinal radiotherapy and anthracyclines in competing risk analyses was 7.9%. In conclusion, risks of several CVDs are 3- to 5-fold increased in survivors of HL compared with the general population, even after prolonged follow-up, leading to increasing absolute excess risks over time. Anthracyclines further increase the elevated risks of CHF and valvular disorders from mediastinal radiotherapy.

Published
2007
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17. Long-term risk of cardiovascular disease after treatment for aggressive non-Hodgkin lymphoma

Author

Moser, Elizabeth C., Noordijk, Evert M., van Leeuwen, Flora E., le Cessie, Saskia, Baars, Joke W., Thomas, José, Carde, Patrice, Meerwaldt, Jacobus H., van Glabbeke, Martine, and Kluin-Nelemans, Hanneke C.

Abstract

Cardiovascular disease frequently occurs after lymphoma therapy, but it is common in the general population too. Therefore, risk estimation requires comparison to population-based rates. We calculated risk by standardized incidence ratios (SIRs) and absolute excess risks (AERs) per 10 000 person-years based on general population rates (Continuous Morbidity Registry Nijmegen) in 476 (Dutch and Belgian) patients with aggressive non-Hodgkin lymphoma (NHL) treated with at least 6 cycles of doxorubicin-based chemotherapy in 4 European Organization for Research on Treatment of Cancer (EORTC) trials (1980-1999). Cumulative incidence of cardiovascular disease, estimated in a competing risk model, was 12% at 5 years and 22% at 10 years (median follow-up, 8.4 years). Risk of chronic heart failure appeared markedly increased (SIR, 5.4; 95% CI, 4.1-6.9) with an AER of 208 excess cases per 10 000 person-years, whereas risk of coronary artery disease matched the general population (SIR, 1.2; 95% CI, 0.8-1.8; AER, 8 per 10 000 person-years). Risk of stroke was raised (SIR, 1.8; 95% CI, 1.1-2.4; AER, 15 per 10 000 person-years), especially after additional radiotherapy (> 40 Gy). Preexisting hypertension, NHL at young age, and salvage treatment increased risk of all cardiovascular events; the effect of radiotherapy was dose dependent. In conclusion, patients are at long-term high risk of chronic heart failure after NHL treatment and need therefore life-long monitoring. In contrast, risk of coronary artery disease appeared more age dependent than treatment related.

Published
2006
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18. FGFR2genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

Author

Ma, Yussanne P., van Leeuwen, Flora E., Cooke, Rosie, Broeks, Annegien, Enciso-Mora, Victor, Olver, Bianca, Lloyd, Amy, Broderick, Peter, Russell, Nicola S., Janus, Cecile, Ashworth, Alan, Houlston, Richard S., and Swerdlow, Anthony J.

Abstract

Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide association studies have identified 14 independently replicated common single nucleotide polymorphisms that influence breast cancer risk. To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P= .000111). These data provide evidence that genetic variation in FGFR2influences radiation-induced breast cancer risk.

Published
2012
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