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14 results on '"Zhang, Run"'

7. Interim Results From a Phase II Study Of Non-Anthracycline Combination Of Oxaliplatin-Gemcitabine Plus Rituximab (R-GemOx) As First-Line Treatment In Elderly Patients With Diffuse Large B-Cell Lymphoma

Author

Fan, Lei, primary, Wang, Li, additional, Xu, Ji, additional, Zhang, Run, additional, Yang, Yuqiong, additional, Huang, Dongping, additional, Shen, Yunfeng, additional, Zhou, Min, additional, Yu, Liang, additional, Zhang, Zhihong, additional, Xu, Wei, additional, and Li, Jianyong, additional

Published
2013
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8. Clinical Study Of Dose-Adjusted EPOCH Regimen For Non-Hodgkin's Lymphoma With Hemophagocytic Lymphohistiocytosis: Preliminary Results Of An Ongoing Phase II Study

Author

Xu, Wei, primary, Fan, Lei, additional, Wang, Li, additional, Xu, Ji, additional, Zhang, Run, additional, Yang, Yuqiong, additional, Huang, Dongping, additional, Shen, Yunfeng, additional, Zhou, Min, additional, Yu, Liang, additional, Zhang, Zhihong, additional, and Li, Jianyong, additional

Published
2013
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12. MiR-15a, Mir-16-1 and Mir-17-92 Cluster Expression Are Linked to Poor Prognosis in Multiple Myeloma

Author

Xiao Gao, Zhang Run, Zhang Sensen, Chen Lijuan, and Qu Xiaoyan

Subjects
Genome instability, Cell growth, Immunology, Cell Biology, Hematology, Biology, Disease cluster, Bioinformatics, medicine.disease, Biochemistry, law.invention, Apoptosis, law, microRNA, Cancer research, medicine, Polymerase chain reaction, Multiple myeloma, Chromosome 13
Abstract

Abstract 5000 Multiple myeloma (MM) is characterized by a profound genomic instability of potential prognostic relevance. Loss of chromosome 13, observed in almost half of patients, negatively affects prognosis. MiR-15a, miR16-1 and miR-17-92 cluster, located on 13q, play important roles in the regulation of cell proliferation, differentiation and apoptosis. Therefore, we investigated a possible correlation of miRNA expression with chromosome 13 deletions (del(13)) and prognosis. We measured the expression of miR-15a, miR16-1 in 70 newly diagnosed MM patients and miR-17-92 cluster in 85 newly diagnosed MM patients by quantitative real-time PCR analyses. MiR-15a, miR-16-1 and miR-17 -92 cluster expression levels are independent of the del(13). High levels of miR-15a, miR-16-1, miR-17, miR-20a and miR-92-1 are associated with shorter progression-free survival (PFS), suggesting poor prognosis. Our data suggest that the expression of specific miRNAs may be contributed to MM prognosis. Disclosures: No relevant conflicts of interest to declare.

Published
2012

14. Clinical Significance of Co-Existence of PHF6and NOTCH1mutations in Adult T-Cell Acute Lymphoblastic Leukemia

Author

Ge, Zheng, Li, Min, Xiao, Lichan, Zhang, Run, and Li, Jianyong

Abstract

Objective:T-cell acute lymphoblastic leukemia (T-ALL) is caused by collaboration of multiple genetic abnormalities in the transformation of T-cell progenitors. PHF6is founded as a new key tumor suppressor and mutated in T-ALL. The clinical significance of PHF6mutations has not been fully determined in adult T-ALL. This study aimed to screen the PHF6mutations in adult T-ALL and explore the associations of PHF6mutations with other genetic lesions, as well as their clinical relevance in adult T-ALL patients.

Published
2015
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