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1. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

Author

Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Gemenetzi, Katerina, Giudicelli, Veronique, Karypidou, Maria, Plevova, Karla, Davis, Zadie, Yan, Xiao-Jie, Jeromin, Sabine, Schneider, Christof, Pedersen, Lone Bredo, Tschumper, Renee C., Sutton, Lesley-Ann, Baliakas, Panagiotis, Scarfò, Lydia, van Gastel, Ellen J., Armand, Marine, Tausch, Eugen, Biderman, Bella, Baer, Constance, Bagnara, Davide, Navarro, Alba, Langlois de Septenville, Anne, Guido, Valentina, Mitterbauer-Hohendanner, Gerlinde, Dimovski, Aleksandar, Brieghel, Christian, Lawless, Sarah, Meggendorfer, Manja, Brazdilova, Kamila, Ritgen, Matthias, Facco, Monica, Tresoldi, Cristina, Visentin, Andrea, Patriarca, Andrea, Catherwood, Mark, Bonello, Lisa, Sudarikov, Andrey, Vanura, Katrina, Roumelioti, Maria, Skuhrova Francova, Hana, Moysiadis, Theodoros, Veronese, Silvio, Giannopoulos, Krzysztof, Mansouri, Larry, Karan-Djurasevic, Teodora, Sandaltzopoulos, Raphael, Bödör, Csaba, Fais, Franco, Kater, Arnon, Panovska, Irina, Rossi, Davide, Alshemmari, Salem, Panagiotidis, Panagiotis, Costeas, Paul, Espinet, Blanca, Antic, Darko, Foroni, Letizia, Montillo, Marco, Trentin, Livio, Stavroyianni, Niki, Gaidano, Gianluca, Francia di Celle, Paola, Niemann, Carsten, Campo, Elias, Anagnostopoulos, Achilles, Pott, Christiane, Fischer, Kirsten, Hallek, Michael, Oscier, David, Stilgenbauer, Stephan, Haferlach, Claudia, Jelinek, Diane, Chiorazzi, Nicholas, Pospisilova, Sarka, Lefranc, Marie-Paule, Kossida, Sofia, Langerak, Anton W., Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2021
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2. Safety and Efficacy of a-319 (a CD3xCD19 T cell engager) in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Author

Liu, Wei Ping, primary, Jiang, Bo, additional, Shuang, Yue Rong, additional, Zhao, Xing, additional, Zhong, Xuan Fan, additional, Tan, Ying, additional, Yu, Guo Jian, additional, Xue, Sheng Jie, additional, Shen, Wu Zhong, additional, Tu, Gui Yun, additional, Yang, Zheng, additional, Chen, Han Yang, additional, Xu, Jason, additional, Liu, Shui, additional, Yan, Xiao Qiang Qiang, additional, Zhu, Jun, additional, and Song, Yu Qin, additional

Published
2023
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3. Integrin Signaling Pathway Is Crucial for the Recently Divided Fraction of CLL Cells and Facilitates Cell Migration in a Disease Progressive Manner

Author

Yan, Xiao J., primary, Palacios, Florencia, additional, Chen, Shih-Shih, additional, Li, Wentian, additional, Rhodes, Joanna M., additional, Barrientos, Jacqueline C., additional, Allen, Steven L, additional, Kolitz, Jonathan E., additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2022
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4. CLECL1+ CLL Cells: A Key Subset That Drives CLL Survival and Proliferation and Shapes a Th2-Biased Tumor Microenvironment

Author

Chen, Shih-Shih, primary, Yan, Xiao-Jie, additional, Cardillo, Martina, additional, Ng, Anita, additional, Shih, Andrew, additional, Blanco, Gonzalo, additional, King-Richards, Morgan, additional, Chen, Yu-Ju, additional, Kieso, Yasmine, additional, Rhodes, Joanna M., additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2022
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6. IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

Author

Patten, Piers E.M., Chu, Charles C., Albesiano, Emilia, Damle, Rajendra N., Yan, Xiao-Jie, Kim, Dorothy, Zhang, Lu, Magli, Amanda R., Barrientos, Jacqueline, Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti R., Roa, Sergio, Mongini, Patricia K., MacCarthy, Thomas, Scharff, Matthew D., and Chiorazzi, Nicholas

Published
2012
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7. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

Author

Agathangelidis, Andreas, Darzentas, Nikos, Hadzidimitriou, Anastasia, Brochet, Xavier, Murray, Fiona, Yan, Xiao-Jie, Davis, Zadie, van Gastel-Mol, Ellen J., Tresoldi, Cristina, Chu, Charles C., Cahill, Nicola, Giudicelli, Veronique, Tichy, Boris, Pedersen, Lone Bredo, Foroni, Letizia, Bonello, Lisa, Janus, Agnieszka, Smedby, Karin, Anagnostopoulos, Achilles, Merle-Beral, Helene, Laoutaris, Nikolaos, Juliusson, Gunnar, di Celle, Paola Francia, Pospisilova, Sarka, Jurlander, Jesper, Geisler, Christian, Tsaftaris, Athanasios, Lefranc, Marie-Paule, Langerak, Anton W., Oscier, David Graham, Chiorazzi, Nicholas, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2012
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9. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

Author

Bagnara, Davide, Kaufman, Matthew S., Calissano, Carlo, Marsilio, Sonia, Patten, Piers E.M., Simone, Rita, Chum, Philip, Yan, Xiao-Jie, Allen, Steven L., Kolitz, Jonathan E., Baskar, Sivasubramanian, Rader, Christoph, Mellstedt, Hakan, Rabbani, Hodjattallah, Lee, Annette, Gregersen, Peter K., Rai, Kanti R., and Chiorazzi, Nicholas

Published
2011
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10. Efficacy of Ibrutinib Monotherapy in Pre-Clinical Mouse Models of Richter Transformation: Ibrutinib Effectively Reduces the Incidence of Richter Transformation but Fails in Treating Transformed Lymphoma, Especially in Primary Lymphoid Tissue

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline, additional, Yan, Xiao-Jie, additional, Wirtz, Uwe, additional, Szafer-Glusman, Edith, additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2021
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14. AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Author

Morande, Pablo Elías, primary, Yan, Xiao-Jie, additional, Sepulveda, Julieta, additional, Seija, Noé, additional, Marquez, María Elena, additional, Sotelo, Natalia, additional, Abreu, Cecilia, additional, Crispo, Martina, additional, Fernández-Graña, Gabriel, additional, Rego, Natalia, additional, Bois, Therence, additional, Methot, Stephen P., additional, Palacios, Florencia, additional, Remedi, Victoria, additional, Rai, Kanti R., additional, Buschiazzo, Alejandro, additional, Di Noia, Javier M., additional, Navarrete, Marcelo A., additional, Chiorazzi, Nicholas, additional, and Oppezzo, Pablo, additional

Published
2021
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15. Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Author

Fang, Tiancheng, primary, Zhang, Yurun, additional, Chang, Vivian Y., additional, Roos, Martina, additional, Termini, Christina M., additional, Signaevskaia, Lia, additional, Quarmyne, Mamle, additional, Lin, Paulina K., additional, Pang, Amara, additional, Kan, Jenny, additional, Yan, Xiao, additional, Javier, Anna, additional, Pohl, Katherine, additional, Zhao, Liman, additional, Scott, Peter, additional, Himburg, Heather A., additional, and Chute, John P., additional

Published
2020
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16. Socioeconomic Disparities in Diagnostic Testing Among Patients with Diffuse Large B-Cell Lymphoma in the US

Author

Donald C. Doll, Yan Xiao, Matthew S Prime, Anup Abraham, Fei Yang, Ju Zhang, and Richard D. Hammer

Subjects
medicine.medical_specialty, business.industry, Immunology, Retrospective cohort study, Cell Biology, Hematology, Odds ratio, medicine.disease, Logistic regression, Biochemistry, Confidence interval, Test (assessment), Internal medicine, Health care, medicine, business, Socioeconomic status, Diffuse large B-cell lymphoma
Abstract

Background A better understanding of diffuse large B-cell lymphoma (DLBCL) subtypes characterized by cell of origin (COO), molecular and immunophenotypic features is associated with more accurate prognosis and may guide treatment selection to achieve better outcomes. Current World Health Organization (WHO) and National Comprehensive Cancer Network (NCCN) guidelines recommend for all patients with DLBCL, immunohistochemistry (IHC, such as Hans algorithm) as a surrogate of gene expression profiling to identify COO, and molecular testing by fluorescence in situ hybridization (FISH) or karyotype to identify molecular/cytogenetic features. Despite advances in treatment and increasing knowledge of clinical importance of DLBCL subtype classification, socioeconomic disparities persist in the treatment of DLBCL in the US (Shenoy PJ, et al. Cancer 2011;117(11):2530-2540) and the use of guideline-recommended diagnostic testing in clinical practice remains unclear. Understanding whether test utilization varies by socioeconomic determinants is important to enable all patients to achieve better/equal access to health care and optimal outcomes. Methods To understand guideline-recommended diagnostic testing utilization in real-world settings and to assess socioeconomic disparities in relation to test utilization among patients with DLBCL in the US, this retrospective cohort study leveraged data from the Flatiron Health electronic health record (EHR)-derived de-identified database. Patients above 18 years old with a diagnosis of DLBCL between Jan-2011 and Dec-2019 were included in the study. Information on IHC, FISH and karyotype analysis was abstracted from pathology reports or clinical visit notes, where available. Utilization of guideline-recommended diagnostic testing was defined as patients with documentation of a confirmed known result on: 1) expression of MYC, BCL2, BCL6, CD10 or MUM1 protein for IHC; and 2) rearrangement of oncogene MYC, BCL2 or BCL6 by FISH or karyotype analysis for molecular testing. 'Not tested' was defined as patients with no evidence/documentation of diagnostic testing for all of the aforementioned markers. Socioeconomic determinants included age, gender, type of insurance plan, race/ethnicity group and geographic location of residency. We assessed changes in rates of IHC and molecular testing during the study follow-up period using Cochran-Armitage trend tests. To assess the impact of socioeconomic determinants on test utilization, multivariable logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI) for IHC and molecular testing separately, while adjusting for several demographic and clinical characteristics. Results In total 5387 patients with DLBCL were included in the study. Guideline-recommended diagnostic testing rates increased between 2011 and 2019 (66.9 to 85.6% for IHC and 49.5 to 67.0% for molecular testing, both P-values Discussion Although the results of this study showed a significant increase in the adoption of guideline-recommended diagnostic testing for patients with DLBCL in the US between 2011-2019, socioeconomic disparities appeared to still exist in the access to molecular testing. Providing equitable access to diagnostic testing would be a critical parameter for patients' clinical benefit. It should be noted that findings about test utilization need cautious interpretation, as patients with DLBCL might have been tested but not documented in the EHR or might have the test performed at sites outside of the Flatiron Health network. Disclosures Yang: F. Hoffmann-La Roche: Current Employment. Zhang:F. Hoffmann-La Roche: Current Employment. Xiao:F. Hoffmann-La Roche: Current Employment. Hammer:PER Med education: Honoraria; PathEdEx: Current equity holder in private company; Caris Lifesciences: Honoraria; Roche: Consultancy, Honoraria, Research Funding. Prime:F. Hoffmann-La Roche: Current Employment.

Published
2020

17. Identification and Reporting of Cell of Origin, Double-/Triple-Hit and Double Expressor Lymphoma in a Real-World Cohort of Diffuse Large B-Cell Lymphoma Patients

Author

Anup Abraham, Matthew S Prime, Ju Zhang, Yan Xiao, Donald C. Doll, Richard D. Hammer, and Fei Yang

Subjects
Oncology, medicine.medical_specialty, Univariate analysis, Hematology, medicine.diagnostic_test, business.industry, Concordance, Immunology, Cell Biology, medicine.disease, BCL6, Biochemistry, Lymphoma, Internal medicine, Cohort, medicine, business, Diffuse large B-cell lymphoma, Fluorescence in situ hybridization
Abstract

Background The distinction of diffuse large B-cell lymphoma (DLBCL) into cell-of-origin (COO) subgroups (germinal center B-cell-like [GCB] or activated B-cell-like [ABC]) based on gene expression profiling is associated with prognosis and has potential therapeutic implications to mitigate the worse outcome for patients with DLBCL. Other phenotypic and molecular/cytogenetic features such as concurrent translocations of oncogene MYC and BCL2 and/or BCL6 (so-called double-/triple-hit lymphoma, DHL/THL) and coexpression of MYC and BCL2 proteins (so-called double-expressor lymphoma, DEL) are also recognized to have great prognostic impact (Swerdlow SH et al. Blood 2016;127(20):2375-2390). This study investigated the prevalence of COO, DHL/THL and DEL in a real-world cohort of patients with DLBCL who had documented results of diagnostic testing. Methods This study used the Flatiron Health electronic health record-derived de-identified database to abstract information on patients diagnosed with DLBCL between 2011-2019. Information on diagnostic testing from immunohistochemistry (IHC) for expression of MYC, BCL2, BCL6, CD10 or MUM1, and from fluorescence in situ hybridization (FISH) or karyotype analysis for rearrangement of MYC, BCL2 or BCL6 was abstracted from pathology reports or clinical visit notes, where available. We calculated the proportions of COO subgroups (GCB vs. ABC) that were derived from IHC testing results according to Hans algorithm (Hans C et al., Blood 2004;103(1):275-282), DHL/THL, and DEL. We also examined concordance of COO classification derived from IHC testing results with that directly reported by the healthcare providers. Differences in patient characteristics between IHC testing results-derived COO subgroups (GCB vs. ABC) were assessed using chi-square tests. Results 4400 patients had documented results of IHC and 73% (n=3194) can be classified into either GCB or ABC DLBCL (GCB/ABC ratio of 1.38). 3205 patients had documented results of FISH or karyotype analysis and 8% (n=245) were DHL/THL; only 33 patients were DEL. Within the GCB DLBCL patients derived from IHC testing results (n=1854), 163 patients were DHL/THL and 11 were DEL, whereas 24 DHL/THL and 18 DEL were identified within the ABC type (n=1340). When comparing COO classification derived from IHC testing results (n=3194) with that directly reported by the healthcare providers (n=2765), additional 695 and 439 patients can be classified as GCB and ABC DLBCL by IHC, respectively (Table). Univariate analysis showed that patients who were non-White ethnic group, diagnosed in academic centers, with lower body mass index but elevated serum lactate dehydrogenase levels and worse ECOG performance status, and without transformation from a prior indolent lymphoid malignancy, were more likely to be associated with ABC DLBCL (for all variables, p Discussion In this large real-world DLBCL cohort, a lower-than-expected proportion of DEL patients were identified vs. the 20-35% reported in the literature (Karube K and Campo E. Hematology 2015;52(2):97-106). This is likely due to our cohort of patients requiring clear evidence of coexpression for MYC and BCL2 (≥40% and >50%, respectively) that are not related to underlying chromosomal rearrangements, and few pathologists reported levels of percent staining for IHC testing among those with documented positive results of MYC/BCL2 protein coexpression. In addition, results from this study showed that only half of cases had COO classification documented by healthcare providers, despite available IHC results. Although this study indicated lack of details in the reporting of diagnostic testing (e.g. COO identification, levels of percent staining, methods for DLBCL subgroup identification), findings should be interpreted with caution, as patients with DLBCL might have been tested but not documented in the electronic health record system or might have biomarker testing performed at sites outside of the Flatiron Health network. Disclosures Yang: F. Hoffmann-La Roche: Current Employment. Zhang:F. Hoffmann-La Roche: Current Employment. Xiao:F. Hoffmann-La Roche: Current Employment. Hammer:Roche: Consultancy, Honoraria, Research Funding; Caris Lifesciences: Honoraria; PER Med education: Honoraria; PathEdEx: Current equity holder in private company. Prime:F. Hoffmann-La Roche: Current Employment.

Published
2020

18. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.

Author

Damle, Rajendra N., Ghiotto, Fabio, Valetto, Angelo, Albesiano, Emilia, Fais, Franco, Yan, Xiao-Jie, Sison, Cristina P., Allen, Steven L., Kolitz, Jonathan, Schulman, Philip, Vinciguerra, Vincent P., Budde, Petra, Frey, Jurgen, Rai, Kanti R., Ferrarini, Manlio, and Chiorazzi, Nicholas

Published
2002
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20. CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Author

Chen, Shih-Shih, primary, Yan, Xiao J., additional, Herndon, Thomas M., additional, Sun, Clare C., additional, Ravichandran, Priyadarshini, additional, Ibrahim, Michael, additional, Sherry, Barbara, additional, Wiestner, Adrian, additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2018
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22. Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Author

Ferrer, Gerardo, primary, Jung, Byeongho, additional, Rukhsana, Aslam, additional, Chiu, Pui Yan, additional, Mazzarello, Andrea Nicola, additional, Palacios, Florenca, additional, Chen, Shih-Shih, additional, Yan, Xiao J., additional, Barrientos, Jacqueline C., additional, Burger, Jan A., additional, Kolitz, Jonathan E., additional, Allen, Steven L., additional, Rai, Kanti R, additional, Sherry, Barbara, additional, and Chiorazzi, Nicholas, additional

Published
2018
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24. Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Author

Gobessi, Stefania, primary, Laurenti, Luca, additional, Porro, Fabiola, additional, Martines, Claudio, additional, Fazio, Rosa, additional, Xerxa, Elena, additional, Innocenti, Idanna, additional, Zucchetto, Antonella, additional, Chen, Shih-Shih, additional, Yan, Xiao-Jie, additional, Chiorazzi, Nicholas, additional, Gattei, Valter, additional, and Efremov, Dimitar G, additional

Published
2018
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25. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Author

Baliakas, Panagiotis, Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Tsanousa, Athina, Scarfò, Lydia, Davis, Zadie, Yan, Xiao-Jie, Shanafelt, Tait, Plevova, Karla, Sandberg, Yorick, Vojdeman, Fie Juhl, Boudjogra, Myriam, Tzenou, Tatiana, Chatzouli, Maria, Chu, Charles C., Veronese, Silvio, Gardiner, Anne, Mansouri, Larry, Smedby, Karin E., Pedersen, Lone Bredo, Moreno, Denis, Van Lom, Kirsten, Giudicelli, Véronique, Francova, Hana Skuhrova, Nguyen-Khac, Florence, Panagiotidis, Panagiotis, Juliusson, Gunnar, Angelis, Lefteris, Anagnostopoulos, Achilles, Lefranc, Marie-Paule, Facco, Monica, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Geisler, Christian H., Langerak, Anton W., Pospisilova, Sarka, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F., Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Ghia, Paolo, Rosenquist, Richard, and Stamatopoulos, Kostas

Published
2015
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27. Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites

Author

Agathangelidis, Andreas, primary, Hadzidimitriou, Anastasia, additional, Minga, Eva, additional, Sutton, Lesley-Ann, additional, Polychronidou, Eleftheria, additional, Shanafelt, Tait D., additional, Davis, Zadie, additional, Yan, Xiao-Jie, additional, Plevova, Karla, additional, Boudjoghra, Myriam, additional, Navarro, Alba, additional, Rossi, Davide, additional, Bredo Pedersen, Lone, additional, Bikos, Vasilis, additional, Baliakas, Panagiotis, additional, Scarfò, Lydia, additional, Mattsson, Mattias, additional, Xochelli, Aliki, additional, di Celle, Paola Francia, additional, Giannopoulos, Krzysztof, additional, Vanura, Katrina, additional, Evers, Ludo, additional, Veronese, Silvio, additional, Facco, Monica, additional, Moschonas, Panagiotis, additional, Bystry, Vojtech, additional, Karan-Djurasevic, Teodora, additional, Roumelioti, Maria, additional, Pavlovic, Sonja, additional, Mansouri, Larry, additional, Chu, Charles, additional, Stalika, Evangelia, additional, Giudicelli, Veronique, additional, Panagiotidis, Panagiotis, additional, Sudarikov, Andrey, additional, Anagnostopoulos, Achilles, additional, Trentin, Livio, additional, Catherwood, Mark, additional, Montillo, Marco, additional, Stavroyianni, Niki, additional, Gaidano, Gianluca, additional, Campo, Elias, additional, Niemann, Carsten Utoft, additional, Langerak, Anton W., additional, Pospisilova, Sarka, additional, Lefranc, Marie-Paule, additional, Jaeger, Ulrich, additional, Kater, Arnon, additional, Pott, Christiane, additional, Chiorazzi, Nicholas, additional, Oscier, David, additional, Jelinek, Diane F., additional, Stilgenbauer, Stephan, additional, Hallek, Michael, additional, Tzovaras, Dimitrios, additional, Darzentas, Nikos, additional, Belessi, Chrysoula, additional, Davi, Frederic, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional

Published
2016
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29. Comparative Density Analyses of B Cell Receptor-Complex Components (Membrane IgM, Membrane IgD, and Stimulatory/Inhibitory Co-Receptors) on Intraclonal Subpopulations of CLL B Cells, before and during Ibrutinib Therapy

Author

Mazzarello, Andrea Nicola, primary, Vergani, Stefano, additional, Ferrer, Gerardo, additional, Liu, Yun, additional, Chen, Shih-Shih, additional, Yancopoulos, Sophia, additional, Yan, Xiao-Jie, additional, Barrientos, Jacqueline C., additional, Rai, Kanti R., additional, and Chiorazzi, Nicholas, additional

Published
2016
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30. Automated Clustering Analysis of Immunoglobulin Sequences in Chronic Lymphocytic Leukemia Based on 3D Structural Descriptors

Author

Marcatili, Paolo, primary, Mochament, Konstantinos, additional, Agathangelidis, Andreas, additional, Moschonas, Panagiotis, additional, Sutton, Lesley-Ann, additional, Yan, Xiao-Jie, additional, Bikos, Vasilis, additional, Vardi, Anna, additional, Chailyan, Anna, additional, Stavroyianni, Niki, additional, Kjærgaard Jensen, Kamilla, additional, Anagnostopoulos, Achilles, additional, Chiorazzi, Nicholas, additional, Belessi, Chrysoula, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, Stamatopoulos, Kostas, additional, Hadzidimitriou, Anastasia, additional, and Tzovaras, Dimitrios, additional

Published
2016
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31. B Cells of the Proliferative Fraction of CLL Clones Exhibit Activated B-Cell and Myeloid-Cell Signatures Suggesting Enhanced Antigen-Presentation, Integrin Responsiveness, and IL-4 Receptiveness: Additional Targets for CLL Therapy

Author

Yan, Xiao-Jie, primary, Palacios, Florencia, additional, Li, Wentian, additional, Yancopoulos, Sophia, additional, Calissano, Carlo, additional, Barrientos, Jacqueline C., additional, Allen, Steven L., additional, Kolitz, Jonathan E., additional, Rai, Kanti, additional, and Chiorazzi, Nicholas, additional

Published
2016
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33. In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

Author

Ferrer, Gerardo, primary, Franca, Brendan, additional, Chiu, Pui Yan, additional, Vergani, Stefano, additional, Mazzarello, Andrea Nicola, additional, Palacios, Florencia, additional, Bagnara, Davide, additional, Chen, Shih-Shih, additional, Yancopoulos, Sophia, additional, Liu, Yun, additional, Xochelli, Aliki, additional, Yan, Xiao-Jie, additional, Barrientos, Jacqueline C., additional, Kolitz, Jonathan E., additional, Allen, Steven L., additional, Stamatopoulos, Kostas, additional, Rai, Kanti R., additional, Sherry, Barbara, additional, and Chiorazzi, Nicholas, additional

Published
2016
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34. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1

Author

Elias Anaissie, Joshua Epstein, Bart Barlogie, David R. Williams, Guido Tricot, Yazan Alsayed, James P. Stewart, Yongsheng Huang, Michele Cottler-Fox, Bob Kordsmeier, Jeffrey R. Sawyer, Ichiro Hanamura, Klaus Hollmig, John D. Shaughnessy, Ronald C. Walker, Fenghuang Zhan, Maurizio Zangari, Hongwei Xu, Frits van Rhee, Simona Colla, Abid Mohiuddin, Yan Xiao, Mauricio Pineda-Roman, Christopher Randolph, Somashekar G. Krishna, Bart Burington, and John Crowley

Subjects
Multivariate analysis, Immunology, Chromosomal translocation, Biology, Bioinformatics, Biochemistry, Cohort Studies, Gene mapping, Recurrence, Risk Factors, medicine, Humans, Survival rate, Multiple myeloma, Aged, Models, Genetic, Microarray analysis techniques, Gene Expression Profiling, Hazard ratio, Chromosome Mapping, Cell Biology, Hematology, medicine.disease, Gene Expression Regulation, Neoplastic, Survival Rate, Gene expression profiling, Chromosomes, Human, Pair 1, Multigene Family, Multiple Myeloma
Abstract

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple myeloma (MM) treated on 2 separate protocols. Using log-rank tests of expression quartiles, 70 genes, 30% mapping to chromosome 1 (P < .001), were linked to early disease-related death. Importantly, most up-regulated genes mapped to chromosome 1q, and down-regulated genes mapped to chromosome 1p. The ratio of mean expression levels of up-regulated to down-regulated genes defined a high-risk score present in 13% of patients with shorter durations of complete remission, event-free survival, and overall survival (training set: hazard ratio [HR], 5.16; P < .001; test cohort: HR, 4.75; P < .001). The high-risk score also was an independent predictor of outcome endpoints in multivariate analysis (P < .001) that included the International Staging System and high-risk translocations. In a comparison of paired baseline and relapse samples, the high-risk score frequency rose to 76% at relapse and predicted short postrelapse survival (P < .05). Multivariate discriminant analysis revealed that a 17-gene subset could predict outcome as well as the 70-gene model. Our data suggest that altered transcriptional regulation of genes mapping to chromosome 1 may contribute to disease progression, and that expression profiling can be used to identify high-risk disease and guide therapeutic interventions.

Published
2006

35. Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites

Author

Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Minga, Eva, Sutton, Lesley-Ann, Polychronidou, Eleftheria, Shanafelt, Tait D., Davis, Zadie, Yan, Xiao-Jie, Plevova, Karla, Boudjoghra, Myriam, Navarro, Alba, Rossi, Davide, Pedersen, Lone Bredo, Bikos, Vasilis, Baliakas, Panagiotis, Scarfo, Lydia, Mattsson, Mattias, Xochelli, Aliki, di Celle, Paola Francia, Giannopoulos, Krzysztof, Vanura, Katrina, Evers, Ludo, Veronese, Silvio, Facco, Monica, Moschonas, Panagiotis, Bystry, Vojtech, Karan-Đurašević, Teodora, Roumelioti, Maria, Pavlović, Sonja, Mansouri, Larry, Chu, Charles, Stalika, Evangelia, Giudicelli, Veronique, Panagiotidis, Panagiotis, Sudarikov, Andrey, Anagnostopoulos, Achilles, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Stavroyianni, Niki, Gaidano, Gianluca, Campo, Elias, Niemann, Carsten Utoft, Langerak, Anton W., Pospisilova, Sarka, Lefranc, Marie-Paule, Jaeger, Ulrich, Kater, Arnon, Pott, Christiane, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F., Stilgenbauer, Stephan, Hallek, Michael, Tzovaras, Dimitrios, Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, Stamatopoulos, Kostas, Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Minga, Eva, Sutton, Lesley-Ann, Polychronidou, Eleftheria, Shanafelt, Tait D., Davis, Zadie, Yan, Xiao-Jie, Plevova, Karla, Boudjoghra, Myriam, Navarro, Alba, Rossi, Davide, Pedersen, Lone Bredo, Bikos, Vasilis, Baliakas, Panagiotis, Scarfo, Lydia, Mattsson, Mattias, Xochelli, Aliki, di Celle, Paola Francia, Giannopoulos, Krzysztof, Vanura, Katrina, Evers, Ludo, Veronese, Silvio, Facco, Monica, Moschonas, Panagiotis, Bystry, Vojtech, Karan-Đurašević, Teodora, Roumelioti, Maria, Pavlović, Sonja, Mansouri, Larry, Chu, Charles, Stalika, Evangelia, Giudicelli, Veronique, Panagiotidis, Panagiotis, Sudarikov, Andrey, Anagnostopoulos, Achilles, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Stavroyianni, Niki, Gaidano, Gianluca, Campo, Elias, Niemann, Carsten Utoft, Langerak, Anton W., Pospisilova, Sarka, Lefranc, Marie-Paule, Jaeger, Ulrich, Kater, Arnon, Pott, Christiane, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F., Stilgenbauer, Stephan, Hallek, Michael, Tzovaras, Dimitrios, Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2016

36. CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous: Antigen Receptor Stereotypy Makes the Difference

Author

Xochelli, Aliki, Baliakas, Panagiotis, Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Tausch, Eugen, Yan, Xiao J., Shanafelt, Tait D., Plevova, Karla, Boudjogra, Myriam, Rossi, Davide, Davis, Zadie, Navarro, Alba, Sandberg, Yorick, Vojdeman, Fie Juhl, Scarfo, Lydia, Stavroyianni, Niki, Sudarikov, Andrey B., Veronese, Silvio, Tzenou, Tatiana, Karan-Đurašević, Teodora, Catherwood, Mark, Kienle, Dirk, Chatzouli, Maria, Facco, Monica, Bahlo, Jasmin, Pedersen, Lone Bredo, Mansouri, Larry, Smedby, Karin E., Chu, Charles C., Giudicelli, Veronique, Lefranc, Marie-Paule, Panagiotidis, Panagiotis, Juliusson, Gunnar, Anagnostopoulos, Achilles, Antić, Darko, Trentin, Livio, Montillo, Marco, Niemann, Carsten, Dohner, Hartmut, Langerak, Anton W., Darzentas, Nikos, Pospisilova, Sarka, Hallek, Michael, Campo, Elias, Chiorazzi, Nicholas, Oscier, David, Gaidano, Gianluca, Belessi, Chrysoula, Jelinek, Diane F., Stilgenbauer, Stephan, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, Stamatopoulos, Kostas, Xochelli, Aliki, Baliakas, Panagiotis, Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Tausch, Eugen, Yan, Xiao J., Shanafelt, Tait D., Plevova, Karla, Boudjogra, Myriam, Rossi, Davide, Davis, Zadie, Navarro, Alba, Sandberg, Yorick, Vojdeman, Fie Juhl, Scarfo, Lydia, Stavroyianni, Niki, Sudarikov, Andrey B., Veronese, Silvio, Tzenou, Tatiana, Karan-Đurašević, Teodora, Catherwood, Mark, Kienle, Dirk, Chatzouli, Maria, Facco, Monica, Bahlo, Jasmin, Pedersen, Lone Bredo, Mansouri, Larry, Smedby, Karin E., Chu, Charles C., Giudicelli, Veronique, Lefranc, Marie-Paule, Panagiotidis, Panagiotis, Juliusson, Gunnar, Anagnostopoulos, Achilles, Antić, Darko, Trentin, Livio, Montillo, Marco, Niemann, Carsten, Dohner, Hartmut, Langerak, Anton W., Darzentas, Nikos, Pospisilova, Sarka, Hallek, Michael, Campo, Elias, Chiorazzi, Nicholas, Oscier, David, Gaidano, Gianluca, Belessi, Chrysoula, Jelinek, Diane F., Stilgenbauer, Stephan, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2015

38. The Correlation of APOBEC Gene Family Member Expression with Worse CLL Patient Outcome Suggests a Role in CLL Mutational Evolution

Author

Chu, Charles C, primary, Yan, Xiao-Jie, additional, Dhayalan, Arvind, additional, Patten, Piers E., additional, MacCarthy, Thomas, additional, Yuan, Chaohui, additional, Barrientos, Jacqueline C., additional, Kolitz, Jonathan E., additional, Allen, Steven L, additional, Rai, Kanti R., additional, and Chiorazzi, Nicholas, additional

Published
2015
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41. Upregulation of Interferon-Inducible and Damage Response Receptors in Chronic Graft-Versus-Host Disease

Author

Hakim, Frances T., primary, Memon, Sarfraz, additional, Jin, Ping, additional, Imanguli, Matin M., additional, Rehman, Najibah, additional, Yan, Xiao-Yi, additional, Rose, Jeremy J., additional, Mays, Jacqueline W., additional, Dhamala, Susan, additional, Kapoor, Veena, additional, Telford, William, additional, Halverson, David C., additional, Baird, Kristin, additional, Fowler, Daniel H., additional, Stroncek, David, additional, Cowen, Edward W., additional, Pavletic, Steven Z., additional, and Gress, Ronald E., additional

Published
2015
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42. CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous: Antigen Receptor Stereotypy Makes the Difference

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, additional, Agathangelidis, Andreas, additional, Hadzidimitriou, Anastasia, additional, Sutton, Lesley-Ann, additional, Minga, Eva, additional, Tausch, Eugen, additional, Yan, Xiao J., additional, Shanafelt, Tait D., additional, Plevova, Karla, additional, Boudjogra, Myriam, additional, Rossi, Davide, additional, Davis, Zadie, additional, Navarro, Alba, additional, Sandberg, Yorick, additional, Vojdeman, Fie Juhl, additional, Scarfo, Lydia, additional, Stavroyianni, Niki, additional, Sudarikov, Andrey B., additional, Veronese, Silvio, additional, Tzenou, Tatiana, additional, Karan-Djurasevic, Teodora, additional, Catherwood, Mark, additional, Kienle, Dirk, additional, Chatzouli, Maria, additional, Facco, Monica, additional, Bahlo, Jasmin, additional, Pedersen, Lone Bredo, additional, Mansouri, Larry, additional, Smedby, Karin E, additional, Chu, Charles C, additional, Giudicelli, Véronique, additional, Lefranc, Marie-Paule, additional, Panagiotidis, Panagiotis, additional, Juliusson, Gunnar, additional, Anagnostopoulos, Achilles, additional, Antic, Darko, additional, Trentin, Livio, additional, Montillo, Marco, additional, Niemann, Carsten, additional, Döhner, Hartmut, additional, Langerak, Anton W., additional, Darzentas, Nikos, additional, Pospisilova, Sarka, additional, Hallek, Michael, additional, Campo, Elias, additional, Chiorazzi, Nicholas, additional, Oscier, David, additional, Gaidano, Gianluca, additional, Belessi, Chrysoula, additional, Jelinek, Diane F., additional, Stilgenbauer, Stephan, additional, Davi, Frederic, additional, Rosenquist, Richard, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional

Published
2015
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48. Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-κB Deregulation in Aggressive Chronic Lymphocytic Leukemia

Author

Mansouri, Larry, primary, Sutton, Lesley-Ann, additional, Ljungstrom, Viktor, additional, Bondza, Sina, additional, Arngarden, Linda, additional, Bhoi, Sujata, additional, Larsson, Jimmy, additional, Cortese, Diego, additional, Kalushkova, Antonia, additional, Gunnarsson, Rebeqa, additional, Young, Emma, additional, Falk-Sorqvist, Elin, additional, Plevova, Karla, additional, Muggen, Alice, additional, Yan, Xiao-Jie, additional, Sander, Birgitta, additional, Enblad, Gunilla, additional, Smedby, Karin E, additional, Juliusson, Gunnar, additional, Belessi, Chrysoula, additional, Chiorazzi, Nicholas, additional, Strefford, Jonathan C, additional, Langerak, Anton W, additional, Pospisilova, Sarka, additional, Davi, Frederic, additional, Hellstrom, Mats, additional, Jernberg Wiklund, Helena, additional, Ghia, Paolo, additional, Soderberg, Ola, additional, Stamatopoulos, Kostas, additional, Nilsson, Mats, additional, and Rosenquist, Richard, additional

Published
2014
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49. Chronic Lymphocytic Leukemia Patients Exhibit Expanded Functional Granulocyte-like Myeloid Derived Suppressor Cells

Author

Ferrer, Gerardo, primary, Simone, Rita, additional, Marsilio, Sonia, additional, Vergani, Stefano, additional, Mazzarello, Andrea Nicola, additional, Chen, Shih-Shih, additional, Yan, Xiao Jie, additional, Sherry, Barbara, additional, Barrientos, Jaqueline C., additional, Kolitz, Jonathan E., additional, Allen, Steven L., additional, Rai, Kanti R., additional, and Chiorazzi, Nicholas, additional

Published
2014
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