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1. Nilotinib (Tasigna®) and Chemotherapy for First-Line Treatment in Elderly Patients with De Novo Philadelphia Chromosome/BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL): A Trial of the European Working Group for Adult ALL (EWALL-PH-02)

Author

Ottmann, Oliver G., primary, Pfeifer, Heike, additional, Cayuela, Jean-Michel, additional, Spiekermann, Karsten, additional, Beck, Joachim, additional, Jung, Wolfram E, additional, Viardot, Andreas, additional, Kerstin, Schäfer-Eckart, additional, Reichle, Albrecht, additional, Maury, Sébastien, additional, Schmitz, Norbert, additional, Heidenreich, Daniela, additional, Panse, Jens, additional, Junghanß, Christian, additional, Raffoux, Emmanuel, additional, Suarez, Felipe, additional, Guillerm, Gäelle, additional, Alexis, Magda, additional, Lissandre, Severine, additional, Huguet, Françoise, additional, Isnard, Françoise, additional, Lepretre, Stephane, additional, Escoffre-Barbe, Martine, additional, Ribera, Josep-Maria, additional, Goekbuget, Nicola, additional, Dombret, Herve, additional, Hoelzer, Dieter, additional, and Rousselot, Philippe, additional

Published
2014
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2. Autologous Followed By Allogeneic Versus Tandem-Autologous Stem Cell Transplant in Newly Diagnosed FISH-del13q Myeloma

Author

Knop, Stefan, primary, Liebisch, Peter, additional, Hebart, Holger, additional, Holler, Ernst, additional, Engelhardt, Monika, additional, Metzner, Bernd, additional, Peest, Dietrich, additional, Aulitzky, Walter, additional, Bunjes, Donald W., additional, Straka, Christian, additional, Fischer, Thomas, additional, Wandt, Hannes, additional, Sezer, Orhan, additional, Hentrich, Markus, additional, Ostermann, Helmut, additional, Peschel, Christian, additional, Hess, Georg, additional, Hertenstein, Bernd, additional, Freund, Mathias, additional, Kropff, Martin H, additional, Wolf, Hans-Heinrich, additional, Jung, Wolfram E, additional, Frickhofen, Norbert, additional, Bargou, Ralf C., additional, Maschmeyer, Georg, additional, Heidemann, Else, additional, Langer, Christian, additional, Kanz, Lothar, additional, Meisner, Christoph, additional, and Einsele, Hermann, additional

Published
2014
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3. Lenalidomide with Low-Dose Dexamethasone (Rd) Continuously Versus Rd Induction, Tandem MEL140 with Autologous Transplantation and Lenalidomide Maintenance: Planned Interim Analysis of a Prospective Randomized Trial in Patients 60-75 Years of Age with Multiple Myeloma

Author

Straka, Christian, primary, Schaefer-Eckart, Kerstin, additional, Bassermann, Florian, additional, Timon, Hansen, additional, Hertenstein, Bernd, additional, Langer, Christian, additional, Salwender, Hans, additional, Knop, Stefan, additional, Engelhardt, Monika, additional, Kropff, Martin, additional, Roesler, Wolf, additional, Decker, Thomas, additional, Hebart, Holger, additional, Frickhofen, Norbert, additional, Reichle, Albrecht, additional, Gerecke, Christian, additional, Metzner, Bernd, additional, Heidemann, Else, additional, Brummendorf, Tim H, additional, Ababei, Juliane, additional, Jung, Wolfram E, additional, Gramatzki, Martin, additional, Hentrich, Marcus, additional, Bojko, Peter, additional, von Metzler, Ivana, additional, Kaufmann, Martin, additional, Naumann, Ralph, additional, Kubin, Thomas, additional, Schmidt, Burkhard, additional, Walther, Jochem, additional, Dechow, Tobias, additional, Wandt, Hannes, additional, Schnabel, Brigitte, additional, Hinke, Axel, additional, and Einsele, Hermann, additional

Published
2014
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4. Peripheral lymph node helper T-cell recovery after syngeneic bone marrow transplantation in mice prepared with either gamma-irradiation or busulfan

Author

Harold M. Johnson, Wolfram E. Samlowski, Man Cheong Fung, Barbara A. Araneo, and Mark O. Butler

Subjects
business.industry, Immunology, Cell Biology, Hematology, Syngeneic Bone Marrow Transplantation, Total body irradiation, Biochemistry, medicine.anatomical_structure, Medicine, Lymph, Bone marrow, business, Peripheral lymph, Lymph node, Busulfan, Preparative Regimen, medicine.drug
Abstract

The optimum marrow ablative regimen for preparing recipients of bone marrow transplantation (BMT) has not been established. gamma- Irradiation, but not busulfan, produces a characteristic microvascular injury pattern which results in depressed capacity of normal lymphocytes to localize into the lymph nodes of syngeneic murine BMT recipients. Since peripheral lymph nodes are important sites for initiation and amplification of immune responses, the preparative regimen might delay recovery of regionally compartmentalized immune functions after BMT. We evaluated the effects of busulfan and gamma- irradiation on the phenotypic and functional reconstitution of helper T- cell function within the peripheral lymph nodes of BMT recipients. Both marrow ablative regimens caused a protracted delay in regeneration of peripheral lymph node CD4+ T cells. Specific helper T-cell functions, such as contact hypersensitivity and alloantigen responses, remained significantly depressed in the lymph nodes of irradiated mice for prolonged periods (up to 60 weeks). These responses recovered more rapidly in busulfan-treated BMT recipients. In contrast, the capacity of peripheral lymph node T cells to provide “help” for antigen-specific immunoglobulin production was only transiently depressed by either preparative regimen. Our experiments confirm the hypothesis that the marrow ablative regimen, particularly gamma-irradiation, may contribute to the period of immunodeficiency which follows BMT. The pattern of immune recovery observed suggests that preparative total body irradiation (TBI) may selectively depress the regional recovery of the TH1 [interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) secreting] lymphocyte subset.

Published
1989
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5. Recovery of contact hypersensitivity responses following murine bone marrow transplantation: comparison of gamma-irradiation and busulfan as preparative marrow-ablative agents

Author

Carol L. Crump and Wolfram E. Samlowski

Subjects
Pathology, medicine.medical_specialty, business.industry, Lymphocyte, Immunology, Cell Biology, Hematology, medicine.disease, Biochemistry, Transplantation, Endothelial stem cell, medicine.anatomical_structure, Immune system, Antigen, Edema, medicine, medicine.symptom, business, Busulfan, Immunodeficiency, medicine.drug
Abstract

Bone marrow transplantation (BMT) is often followed by significant morbidity and mortality due to protracted immunodeficiency. We have hypothesized that the bone marrow-ablative regimen may delay the recovery of normal immune function following transplantation by impairing the interaction of host endothelial cells with circulating graft-derived lymphocytes. This report compares the relative effects of busulfan (an alkylating drug) and gamma-irradiation on the tissue- specific localization potential of lymphocytes and the eventual recovery of immune function within syngeneic murine transplant recipients. Localization of normal lymphocytes into peripheral lymph nodes of irradiated BMT recipients was markedly less (less than 50%) than in busulfan-treated or normal mice over the first 2 months post- BMT. This finding correlated with irradiation-induced endothelial cell edema and microvascular occlusions within lymphocyte-receptive areas of the nodal microvasculature. The effect of both preparative regimens on the recovery of contact hypersensitivity (CHS) was also analyzed. This response recovered more quickly (between 1 and 2 months) in busulfan- pretreated animals. Further experiments demonstrated that the decrease in CHS responsiveness appeared, in part, related to a depression in the capacity of lymphocytes to localize into skin sites of antigen deposition within irradiated mice. The impairment of tissue-specific lymphocyte localization may represent a novel mechanism by which whole body irradiation can contribute to delayed immunologic reconstitution following bone marrow transplantation.

Published
1987
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6. Peripheral Lymph Node Helper T-Cell Recovery After Syngeneic Bone Marrow Transplantation in Mice Prepared With Either γ-Irradiation or Busulfan

Author

Samlowski, Wolfram E., Araneo, Barbara A., Butler, Mark O., Fung, Man Cheong, and Johnson, Harold M.

Abstract

The optimum marrow ablative regimen for preparing recipients of bone marrow transplantation (BMT) has not been established. γ-Irradiation, but not busulfan, produces a characteristic microvascular injury pattern which results in depressed capacity of normal lymphocytes to localize into the lymph nodes of syngeneic murine BMT recipients. Since peripheral lymph nodes are important sites for initiation and amplification of immune responses, the preparative regimen might delay recovery of regionally compartmentalized immune functions after BMT. We evaluated the effects of busulfan and γ-irradiation on the phenotypic and functional reconstitution of helper T-cell function within the peripheral lymph nodes of BMT recipients. Both marrow ablative regimens caused a protracted delay in regeneration of peripheral lymph node CD4+T cells. Specific helper T-cell functions, such as contact hypersensitivity and alloantigen responses, remained significantly depressed in the lymph nodes of irradiated mice for prolonged periods (up to 60 weeks). These responses recovered more rapidly in busulfan-treated BMT recipients. In contrast, the capacity of peripheral lymph node T cells to provide “help” for antigen-specific immunoglobulin production was only transiently depressed by either preparative regimen. Our experiments confirm the hypothesis that the marrow ablative regimen, particularly γ-irradiation, may contribute to the period of immunodeficiency which follows BMT. The pattern of immune recovery observed suggests that preparative total body irradiation (TBI) may selectively depress the regional recovery of the TH1[interleukin-2 (IL-2) and γ-interferon (γ-IFN) secreting] lymphocyte subset.

Published
1989
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7. Nilotinib (Tasigna®) and Chemotherapy for First-Line Treatment in Elderly Patients with De NovoPhiladelphia Chromosome/BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL): A Trial of the European Working Group for Adult ALL (EWALL-PH-02)

Author

Ottmann, Oliver G., Pfeifer, Heike, Cayuela, Jean-Michel, Spiekermann, Karsten, Beck, Joachim, Jung, Wolfram E, Viardot, Andreas, Kerstin, Schäfer-Eckart, Reichle, Albrecht, Maury, Sébastien, Schmitz, Norbert, Heidenreich, Daniela, Panse, Jens, Junghanß, Christian, Raffoux, Emmanuel, Suarez, Felipe, Guillerm, Gäelle, Alexis, Magda, Lissandre, Severine, Huguet, Françoise, Isnard, Françoise, Lepretre, Stephane, Escoffre-Barbe, Martine, Ribera, Josep-Maria, Goekbuget, Nicola, Dombret, Herve, Hoelzer, Dieter, and Rousselot, Philippe

Published
2014
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