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1. High Frequency of the Ph-like PCB-ALL Subtype in Mexican Pediatric Patients. Experience in Two Institutions

Author

Perez-Vera, Patricia, primary, Moreno Lorenzana, Dafne, additional, Juárez-Velázquez, María Del Rocío, additional, Martínez-Anaya, Daniel Alejandro, additional, Reyes-León, Adriana, additional, Hernández-Monterde, Adrián, additional, Aguilar, Maria Montserrat, additional, Soto Lerma, Oscar, additional, Herrera-Almanza, Martha, additional, Zapata-Tarres, Marta, additional, Juarez-Villegas, Luis, additional, Cardenas-Cardos, Rocio, additional, Rivera-Luna, Roberto, additional, and Olaya-Vargas, Alberto, additional

Published
2018
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2. Variants in ARID5B Gene Are Associated with the Development of Acute Lymphoblastic Leukemia in Mexican Children

Author

Reyes-León, Adriana, primary, Fernández-García, Diana, additional, Ramírez-Martínez, Maribel, additional, Amaro-Muñoz, David, additional, Velázquez-Aragón, José Antonio, additional, Salas-Labadía, Consuelo, additional, Zapata-Tarres, Marta, additional, Velasco-Hidalgo, Liliana, additional, Lopez-Santiago, Norma, additional, López-Ruíz, Mayra Ivette, additional, Malavar-Guadarrama, Mónica Anabell, additional, Cardenas-Cardos, Rocio, additional, Paredes-Aguilera, Rogelio Alejandro, additional, Dean, Michael, additional, Rivera-Luna, Roberto, additional, and Perez-Vera, Patricia, additional

Published
2018
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3. Variants in ARID5BGene Are Associated with the Development of Acute Lymphoblastic Leukemia in Mexican Children

Author

Reyes-León, Adriana, Fernández-García, Diana, Ramírez-Martínez, Maribel, Amaro-Muñoz, David, Velázquez-Aragón, José Antonio, Salas-Labadía, Consuelo, Zapata-Tarres, Marta, Velasco-Hidalgo, Liliana, Lopez-Santiago, Norma, López-Ruíz, Mayra Ivette, Malavar-Guadarrama, Mónica Anabell, Cardenas-Cardos, Rocio, Paredes-Aguilera, Rogelio Alejandro, Dean, Michael, Rivera-Luna, Roberto, and Perez-Vera, Patricia

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most common subtype of leukemia diagnosed in children under 18 years. According to the statistics of the Popular Medical Insurance Program in Mexico, the ALL incidence is 79.8 cases per million per year, and it is significantly increasing. Recently, several SNPs of ARID5Bgene have been associated with ALL susceptibility and are more strongly related with ALL risk in Hispanics. However, these observations are not necessarily representative of the situation in Mexico, since the proportion of Mexican patients included in these studies is unknown. It is essential for us to know if the genetic variants of ARID5Bconfer susceptibility to the development of the disease in our population and if these variants contribute to the higher incidence of childhood ALL in Mexico.

Published
2018
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