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14 results on '"Tiwari, Anand"'

1. Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Author

Dima, Danai, primary, Hasipek, Metis, additional, Singh, Divya Jyoti, additional, Jiang, Dongxu, additional, Tiwari, Anand D., additional, Grabowski, Dale, additional, Parker, Yvonne, additional, Lindner, Daniel J., additional, Zhao, Jianjun, additional, Shain, Kenneth H., additional, Khouri, Jack, additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2022
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3. TET2 Inhibitory Effects of Eltrombopag Contribute Its Hematopoietic Activity

Author

Guan, Yihong, primary, Hasipek, Metis, additional, Patel, Bhumika J., additional, Grabowski, Dale, additional, Tiwari, Anand D., additional, Kongkiatkamon, Sunisa, additional, Kerr, Cassandra M, additional, Nazha, Aziz, additional, Saunthararajah, Yogenthiran, additional, Sekeres, Mikkael A., additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2020
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5. Inhibition of Critical DNA Dioxygenase Activity in IDH1/2 Mutant Myeloid Neoplasms

Author

Pagliuca, Simona, primary, Guan, Yihong, additional, Tiwari, Anand D., additional, Grabowski, Dale, additional, Gurnari, Carmelo, additional, Kerr, Cassandra M, additional, Kongkiatkamon, Sunisa, additional, Hasipek, Metis, additional, Terkawi, Laila, additional, Zawit, Misam, additional, Awada, Hassan, additional, Visconte, Valeria, additional, Saunthararajah, Yogenthiran, additional, Phillips, James G, additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2020
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6. TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia

Author

Guan, Yihong, primary, Tiwari, Anand D., primary, Phillips, James G, primary, Hasipek, Metis, primary, Grabowski, Dale, primary, Kerr, Cassandra M, primary, Adema, Vera, primary, Nagata, Yasunobu, primary, Visconte, Valeria, primary, Radivoyevitch, Tomas, primary, Lindner, Daniel, primary, Meggendorfer, Manja, primary, Abazeed, Mohamed, primary, Sekeres, Mikkael A., primary, Haferlach, Torsten, primary, Maciejewski, Jaroslaw P., primary, and Jha, Babal K., primary

Published
2019
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7. Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Author

Visconte, Valeria, primary, Adema, Vera, primary, Tiwari, Anand D., primary, Kerr, Cassandra M, primary, Awada, Hassan, primary, Przychodzen, Bartlomiej, primary, Noe, Allison, primary, Toth, Rachel, primary, Snider, Christina, primary, Parker, Yvonne, primary, Fedorov, Yuriy, primary, Adams, Drew, primary, Carraway, Hetty E., primary, Advani, Anjali S., primary, Kelly, Kevin R, primary, Nawrocki, Steffan T., primary, Carew, Jennifer S., primary, Rogers, Heesun J., primary, Lindner, Daniel J., primary, Sekeres, Mikkael A., primary, Phillips, James G, primary, and Maciejewski, Jaroslaw P., primary

Published
2019
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8. Therapeutic Applications of a Unique Calcium Channel Blocker to Target SF3B1 MDS

Author

Kongkiatkamon, Sunisa, primary, Tiwari, Anand, primary, Adema, Vera, primary, Kerr, Cassandra M, primary, Przychodzen, Bartlomiej, primary, Awada, Hassan, primary, Durrani, Jibran, primary, Parker, Yvonne, primary, Adams, Drew, primary, Fedorov, Yuriy, primary, Carraway, Hetty E., primary, Yang, Chao-Yie, primary, Sekeres, Mikkael A., primary, Lindner, Daniel J., primary, Phillips, James G, primary, Maciejewski, Jaroslaw P., primary, and Visconte, Valeria, primary

Published
2019
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9. Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Author

Kongkiatkamon, Sunisa, primary, Guan, Yihong, additional, Tiwari, Anand, additional, Maciejewski, Phillip J, additional, Grabowski, Dale, additional, Vatolin, Sergei, additional, Adema, Vera, additional, Kerr, Cassandra M, additional, Nagata, Yasunobu, additional, Co, Milo, additional, Snider, Christina, additional, Awada, Hassan, additional, Durrani, Jibran, additional, Parker, Yvonne, additional, Lindner, Daniel J., additional, Sekeres, Mikkael A., additional, Visconte, Valeria, additional, Phillips, James G, additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2019
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11. Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Author

Guan, Yihong, primary, Tiwari, Anand D., additional, Hasipek, Metis, additional, Grabowski, Dale, additional, Parker, Yvonne, additional, Hirsch, Cassandra M., additional, Graham, Amy C, additional, Nagata, Yasunobu, additional, Przychodzen, Bartlomiej P., additional, Nazha, Aziz, additional, Lindner, Daniel, additional, Radivoyevitch, Tomas, additional, Phillips, James G, additional, Maciejewski, Jaroslaw P., additional, and Jha, Babal K., additional

Published
2018
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13. Pharmacologic Normalization of Altered Transcriptome of SF3B1Mutant Myeloid Neoplasia

Author

Visconte, Valeria, Adema, Vera, Tiwari, Anand D., Kerr, Cassandra M, Awada, Hassan, Przychodzen, Bartlomiej, Noe, Allison, Toth, Rachel, Snider, Christina, Parker, Yvonne, Fedorov, Yuriy, Adams, Drew, Carraway, Hetty E., Advani, Anjali S., Kelly, Kevin R, Nawrocki, Steffan T., Carew, Jennifer S., Rogers, Heesun J., Lindner, Daniel J., Sekeres, Mikkael A., Phillips, James G, and Maciejewski, Jaroslaw P.

Abstract

SF3B1mutations disrupt normal pre-mRNA splicing to cause disease. Drugs inhibiting the interaction between the SF3b complex and RNA or agents degrading auxiliary splicing factors are being tested as new avenues for targeted therapy in myeloid neoplasia (MN) with SF3B1mutations. Here we describe the ability of small molecules to restore altered RNA processes in SF3B1MTMN.

Published
2019
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14. Targeting NAD+Modulating Enzymes to Improve HSC Function in Aging and Bone Marrow Failure

Author

Maciejewski, Phillip J, Guan, Yihong, Hasipek, Metis, Tiwari, Anand D., Grabowski, Dale, Phillips, James G, Saunthararajah, Yogenthiran, Maciejewski, Jaroslaw P., and Jha, Babal K.

Abstract

Human hematopoietic system produces various types of differentiated and short-lived cells with specialized functions, which require continuous replenishment through the function of hematopoietic stem cells (HSC). HSC failure is a common distal endpoint of various pathogenic mechanisms in almost all bone marrow failure (BMF) syndromes and associated diseases. Hematopoietic growth factor cocktails (HGF) used in expanding bone marrow cells e.g.,to increase cellularity of the HSC grafts, lead to differentiation and decreased HSC count. Theoretically, when used in vivo, they may act on progenitors rather than HSC and lead to stimulation of clonal outgrowth. Our current ability to stimulate HSC self-renewal to provide reconstitution of long-term hematopoiesis is limited.

Published
2018
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