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4. Analysis of 179 Patients with Newly Diagnosed Multiple Myeloma (MM) Treated with Novel Agents Followed by Autologous Stem Cell Transplantation (ASCT): a Retrospective Study

Author

Habib, Joyce, primary, Dunavin, Neil, additional, Phillips, Gary, additional, Elder, Patrick, additional, Tranovich, Meaghan, additional, Benson, Don M, additional, Hofmeister, Craig C., additional, Byrd, John C., additional, Devine, Steven M., additional, and Efebera, Yvonne, additional

Published
2010
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5. Late Mortality and Relapse Following HLA-Identical Sibling Donor Marrow Transplantation for Chronic Myeloid Leukemia.

Author

Copelan, Edward, primary, Crilley, Pamela, additional, Szer, Jeffrey, additional, Dodds, Anthony J., additional, Stevenson, Dustin E., additional, Phillips, Gary, additional, Elder, Patrick, additional, Nivison-Smith, Ian, additional, Avalos, Belinda, additional, Penza, Sam, additional, Topolsky, David, additional, Sobecks, R., additional, Kalaycio, Matt, additional, and Bolwell, Brian J., additional

Published
2008
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6. Incidence of Late Failure Following Myeloablative Conditioning with BuCy2 and Matched Sibling Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia.

Author

Pant, Shubham, primary, Hamadani, Sayed Mehdi, primary, Crilley, Pamela, primary, Szer, Jeffrey, primary, Dodds, Anthony J., primary, Stevenson, Dustin E., primary, Phillips, Gary, primary, Elder, Patrick, primary, Nivison-Smith, Ian, primary, Avalos, Belinda, primary, Penza, Sam, primary, Topolsky, David, primary, Sobecks, R., primary, Kalaycio, Matt, primary, Bolwell, Brian J., primary, and Copelan, Edward, primary

Published
2008
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9. Human CTLA4knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

Author

Lute, Kenneth D., Kenneth, F., Lu, Ping, Zhang, Huiming, Kocak, Ergun, Mosinger, Bedrick, Wolford, Christopher, Phillips, Gary, Caligiuri, Michael A., Zheng, Pan, and Liu, Yang

Abstract

Although results from preclinical studies in animal models have proven the concept for use of anti–cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibodies in cancer immunotherapy, 2 major obstacles have hindered their successful application for human cancer therapy. First, the lack of in vitro correlates of the antitumor effect of the antibodies makes it difficult to screen for the most efficacious antibody by in vitro analysis. Second, significant autoimmune side effects have been observed in a recent clinical trial. In order to address these 2 issues, we have generated human CTLA4gene knock-in mice and used them to compare a panel of anti–human CTLA-4 antibodies for their ability to induce tumor rejection and autoimmunity. Surprisingly, while all antibodies induced protection against cancer and demonstrated some autoimmune side effects, the antibody that induced the strongest protection also induced the least autoimmune side effects. These results demonstrate that autoimmune disease does not quantitatively correlate with cancer immunity. Our approach may be generally applicable to the development of human therapeutic antibodies.

Published
2005
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