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1. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Author

Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael S., Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul G., Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., and Morin, Ryan D.

Published
2023
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2. DNA Methylation-Based Burkitt Lymphoma Epitypes Have Distinct Molecular and Clinical Features

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K, additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony, additional, Casper, Corey, additional, Dyer, Maureen, additional, Esteller, Manel, additional, Garcia-Prieto, Carlos, additional, Gastier-Foster, Julie M, additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy C., additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy Lee, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin D, additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven J, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D., additional

Published
2022
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3. Novel Genetic Subgroups Inform on Shared Pathobiology within Adult and Pediatric Burkitt Lymphoma

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K, additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony, additional, Casper, Corey, additional, Cruz, Manuela, additional, Dyer, Maureen, additional, Gastier-Foster, Julie M, additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy C., additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy Lee, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin, additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven, additional, Soudi, Shaghayegh, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Wong, Jasper, additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D, additional

Published
2021
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5. Molecular Correlates of Central Nervous System Relapse in Diffuse Large B-Cell Lymphoma

Author

Kridel, Robert, primary, Isaev, Keren, additional, Ennishi, Daisuke, additional, Skinnider, Brian, additional, Mungall, Karen, additional, Mungall, Andrew J., additional, Bakhtiari, Mehran, additional, Tremblay-Lemay, Rosemarie, additional, Meissner, Barbara, additional, Ben-Neriah, Susana, additional, Boyle, Merrill, additional, Villa, Diego, additional, Marra, Marco A., additional, Steidl, Christian, additional, Gascoyne, Randy D., additional, Savage, Kerry J, additional, and Scott, David W., additional

Published
2019
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6. Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative

Author

Tarlock, Katherine, primary, Kaeding, Allison J., additional, Alonzo, Todd A., additional, Loken, Michael R., additional, Ries, Rhonda E., additional, Pardo, Laura, additional, Gerbing, Robert, additional, Farrar, Jason E, additional, Guidry Auvil, Jaime M., additional, Gerhard, Daniela S., additional, Smith, Malcolm A., additional, Davidsen, Tanja M., additional, Gesuwan, Pattee, additional, Hermida, Leandro C., additional, Marra, Marco A., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Long, William, additional, Gamis, Alan S., additional, Kolb, E. Anders, additional, and Meshinchi, Soheil, additional

Published
2016
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7. ASXL1 and ASXL2 Mutations in Childhood AML Are Strongly Associated with t(8;21) but Do Not Independently Impact on Prognosis: A Report from the Children's Oncology Group and NCI/COG Target Initiative

Author

Farrar, Jason E., primary, Alonzo, Todd A., additional, Ries, Rhonda E., additional, Gerbing, Robert B., additional, Guidry Auvil, Jaime M., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Long, William, additional, Zong, Stuart, additional, Kolb, E. Anders, additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Gamis, Alan S., additional, and Meshinchi, Soheil, additional

Published
2015
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8. Rearrangements in Nucleoporin Family of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

Author

Ostronoff, Fabiana, primary, Ries, Rhonda E., additional, Gerbing, Robert B., additional, Marra, Marco A, additional, Yussanne, Ma, additional, Long, William, additional, Zong, Stuart, additional, Mungall, Karen, additional, Andrew, Andrew, additional, Gerhard, Daniela S., additional, Smith, Malcolm A., additional, Patee, Gesuwan, additional, Davidsen, Tanja M., additional, Hermida, Leandro C., additional, Farrar, Jason E., additional, Auvil, Jaime Guidry, additional, Raimondi, Susana C., additional, Hirsch, Betsy A., additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Alonzo, Todd A., additional, and Meshinchi, Soheil, additional

Published
2015
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9. Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative

Author

Tarlock, Katherine, primary, Hansen, M. Eva, additional, Hylkema, Tiffany, additional, Ries, Rhonda, additional, Farrar, Jason E., additional, Auvil, Jaime Guidry, additional, Gerhard, Daniela S., additional, Smith, Malcolm A., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Long, William, additional, Boggon, Titus, additional, Alonzo, Todd A., additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, and Meshinchi, Soheil, additional

Published
2015
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11. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing

Author

Morin, Ryan D., primary, Mungall, Karen, additional, Pleasance, Erin, additional, Mungall, Andrew J., additional, Goya, Rodrigo, additional, Huff, Ryan D., additional, Scott, David W., additional, Ding, Jiarui, additional, Roth, Andrew, additional, Chiu, Readman, additional, Corbett, Richard D., additional, Chan, Fong Chun, additional, Mendez-Lago, Maria, additional, Trinh, Diane L., additional, Bolger-Munro, Madison, additional, Taylor, Greg, additional, Hadj Khodabakhshi, Alireza, additional, Ben-Neriah, Susana, additional, Pon, Julia, additional, Meissner, Barbara, additional, Woolcock, Bruce, additional, Farnoud, Noushin, additional, Rogic, Sanja, additional, Lim, Emilia L., additional, Johnson, Nathalie A., additional, Shah, Sohrab, additional, Jones, Steven, additional, Steidl, Christian, additional, Holt, Robert, additional, Birol, Inanc, additional, Moore, Richard, additional, Connors, Joseph M., additional, Gascoyne, Randy D., additional, and Marra, Marco A., additional

Published
2013
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12. Identification of Genes Frequently Mutated In FL and DLBCL with Transcriptome, Genome and Exome Sequencing

Author

Morin, Ryan D, primary, Mendez-Lago, Maria, additional, Mungall, Andrew J, additional, Johnson, Nathalie A, additional, Goya, Rodrigo, additional, Severson, Tesa, additional, Mungall, Karen, additional, An, Jianghong, additional, Yakovenko, Oleksandr, additional, Jackman, Shaun, additional, Krzywinski, Martin, additional, Griffith, Malachi, additional, Chan, Susanna, additional, Tam, Angela, additional, Smailus, Duane, additional, McDonald, Helen, additional, Moksa, Michelle, additional, Boyle, Merrill, additional, Woolcock, Bruce, additional, Zeng, Thomas, additional, Zhao, Yongjun, additional, Holt, Robert A, additional, Moore, Richard, additional, Schein, Jacqueline E, additional, Birol, Inanc, additional, Horsman, Douglas E, additional, Jones, Steven J, additional, Connors, Joseph M., additional, Hirst, Martin, additional, Gascoyne, Randy D., additional, and Marra, Marco A, additional

Published
2010
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13. Mutations In MLL2 and MEF2B Genes In Follicular Lymphoma and Diffuse Large B-Cell Lymphoma

Author

Mendez-Lago, Maria, primary, Morin, Ryan D, additional, Mungall, Andrew J, additional, Chan, Susanna, additional, Chittaranjan, Suganthi, additional, Severson, Tesa, additional, Goya, Rodrigo, additional, Mungall, Karen, additional, Johnson, Nathalie A, additional, Boyle, Merrill, additional, Woolcock, Bruce, additional, Zeng, Thomas, additional, McDonald, Helen, additional, An, Jianghong, additional, Yakovenko, Oleksandr, additional, Tam, Angela, additional, Zhao, Yongjun, additional, Hirst, Martin, additional, Moore, Richard, additional, Schein, Jacqueline E, additional, Jones, Steven J, additional, Horsman, Douglas E, additional, Gascoyne, Randy D., additional, Connors, Joseph M., additional, and Marra, Marco A, additional

Published
2010
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14. Base-Pair Resolution of Somatic and Germline-Derived Genome Rearrangement Breakpoints in Follicular Lymphoma.

Author

Mungall, Andrew J., primary, Chu, Andy, additional, Chiu, Readman, additional, Corbett, Richard, additional, Field, Matthew A., additional, Jackman, Shaun D., additional, Mungall, Karen L., additional, Wong, Kim, additional, Boyle, Merrill, additional, Carlsen, Rebecca, additional, Chan, Susanna Y., additional, Coope, Robin J.N., additional, Hirst, Carrie A., additional, Hirst, Martin, additional, Johnson, Nathalie, additional, Krzywinski, Martin, additional, Lee, Darlene, additional, Lin, Jasmine BingXue, additional, Moore, Richard, additional, Severson, Tesa, additional, Simpson, Jared T., additional, Steidl, Christian, additional, Zeng, Thomas, additional, Zhao, Yongjun, additional, Birol, Inanc, additional, Holt, Robert A., additional, Jones, Steven J., additional, Gascoyne, Randy D., additional, Horsman, Douglas E., additional, Connors, Joseph M., additional, Schein, Jacqueline E., additional, and Marra, Marco A., additional

Published
2009
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15. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Author

Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael, Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul, Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., and Morin, Ryan D.

Abstract

Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), leaving its relationship to adult BL (aBL) and other adult lymphomas not fully explored. We sought to more thoroughly identify the somatic changes that underlie lymphomagenesis in aBL and any molecular features that associate with clinical disparities within and between pBL and aBL. Through comprehensive whole-genome sequencing of 230 BL and 295 diffuse large B-cell lymphoma (DLBCL) tumors, we identified additional significantly mutated genes, including more genetic features that associate with tumor Epstein-Barr virus status, and unraveled new distinct subgroupings within BL and DLBCL with 3 predominantly comprising BLs: DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3and CCND3), and Q53-BL (quiet TP53). Each BL subgroup is characterized by combinations of common driver and noncoding mutations caused by aberrant somatic hypermutation. The largest subgroups of BL cases, IC-BL and DGG-BL, are further characterized by distinct biological and gene expression differences. IC-BL and DGG-BL and their prototypical genetic features (ID3and TP53) had significant associations with patient outcomes that were different among aBL and pBL cohorts. These findings highlight shared pathogenesis between aBL and pBL, and establish genetic subtypes within BL that serve to delineate tumors with distinct molecular features, providing a new framework for epidemiologic, diagnostic, and therapeutic strategies.

Published
2022
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16. ASXL1and ASXL2Mutations in Childhood AML Are Strongly Associated with t(8;21) but Do Not Independently Impact on Prognosis: A Report from the Children's Oncology Group and NCI/COG Target Initiative

Author

Farrar, Jason E., Alonzo, Todd A., Ries, Rhonda E., Gerbing, Robert B., Guidry Auvil, Jaime M., Davidsen, Tanja M., Gesuwan, Patee, Hermida, Leandro C., Marra, Marco A, Mungall, Andrew J., Mungall, Karen, Ma, Yussanne, Long, William, Zong, Stuart, Kolb, E. Anders, Smith, Malcolm A., Gerhard, Daniela S., Gamis, Alan S., and Meshinchi, Soheil

Abstract

Increasing use of high-throughput sequencing technologies has enabled the identification of novel somatic gene alterations in cancers, with important implications in understanding the mechanisms of transformation and potentially in improving therapeutic decision-making. In contrast to many solid tumors, the mutational spectrum of acute myeloid leukemia (AML) has proven bland, with relatively few recurrent somatic mutations per tumor. This result appears more pronounced in pediatric AML, where even mutation of genes commonly mutated in adult disease, such as IDH1/2or DNMT3A, appear at much lower frequencies. Alterations of ASXL1, a regulator of the polycomb-repressive complex, have been identified in adults with myelodysplastic syndromes, myeloproliferative syndromes, and AML. Mutations in the related gene family member, ASXL2, were recently associated with t(8;21) AML in adults and children. In this study, we evaluated the prevalence and prognostic impact of mutations of these epigenetic regulator genes in pediatric AML patients treated on COG studies AAML03P1 and AAML0531.

Published
2015
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17. Rearrangements in NucleoporinFamily of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

Author

Ostronoff, Fabiana, Ries, Rhonda E., Gerbing, Robert B., Marra, Marco A, Yussanne, Ma, Long, William, Zong, Stuart, Mungall, Karen, Andrew, Andrew, Gerhard, Daniela S., Smith, Malcolm A., Patee, Gesuwan, Davidsen, Tanja M., Hermida, Leandro C., Farrar, Jason E., Auvil, Jaime Guidry, Raimondi, Susana C., Hirsch, Betsy A., Kolb, E. Anders, Gamis, Alan S., Alonzo, Todd A., and Meshinchi, Soheil

Abstract

Genetic alterations in the Nucleoporin(NUP)family of genes are involved in myeloid leukemogenesis and are associated with poor prognosis. We previously showed that NUP98-NSD1is prevalent in acute myeloid leukemia (AML) and is highly associated with FLT3-ITD and dismal outcome. As genetic alterations in the NUPfamily are frequently cryptic by conventional karyotyping, their incidence has been underestimated.

Published
2015
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