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3. Trial in Progress: A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE ® Antibody Blinatumomab (Blincyto) and Vincristine Sulfate Liposomal Injection (Marqibo) in Adult Subjects with Relapsed/Refractory Philadelphia Negative CD19+ Acute Lymphoblastic Leukemia

Author

Rizzieri, David A, primary, Leonard, Jessica, additional, Badar, Talha, additional, Chen, Franklin L., additional, Shah, Bijal D., additional, and Li, Zhiguo, additional

Published
2021
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4. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation

Author

Jia, Wei, primary, Poe, Jonathan C., additional, Su, Hsuan, additional, Anand, Sarah, additional, Matsushima, Glenn K., additional, Rathmell, Jeffrey C., additional, Maillard, Ivan, additional, Radojcic, Vedran, additional, Imai, Kazuhiro, additional, Reyes, Nancy J., additional, Cardona, Diana M., additional, Li, Zhiguo, additional, Suthers, Amy N., additional, Curry-Chisolm, Itaevia M., additional, DiCioccio, Rachel A., additional, Saban, Daniel R., additional, Chen, Benny J., additional, Chao, Nelson J., additional, and Sarantopoulos, Stefanie, additional

Published
2021
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5. Morphologic Leukemia-Free State in Acute Myeloid Leukemia Is Sufficient for Successful Allogeneic Hematopoietic Stem Cell Transplant

Author

Pabon, Cindy M., primary, Li, Zhiguo, additional, Hennig, Therese, additional, De Castro, Carlos, additional, Neff, Jadee, additional, Horwitz, Mitchell E., additional, Leblanc, Thomas W., additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Sung, Anthony D., additional, Chao, Nelson J., additional, Gasparetto, Cristina, additional, Sarantopoulos, Stefanie, additional, Adams, Donna B., additional, Erba, Harry P., additional, and Rizzieri, David A, additional

Published
2020
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6. Evaluation of the Oral SYK Inhibitor Fostamatinib in Patients after Allogeneic Transplantation for Chronic Graft-Versus-Host Disease

Author

McManigle, William C., primary, DiCioccio, Rachel A., additional, Anand, Sarah, additional, Li, Zhiguo, additional, Poe, Jonathan C, additional, Nichols, Krista R., additional, Suthers, Amy N., additional, Jia, Wei, additional, Corbet, Kelly, additional, Covington, Megan, additional, Lloyd-Cowden, Julia, additional, Lopez, Richard D., additional, Long, Gwynn D., additional, Horwitz, Mitchell E., additional, Gasparetto, Cristina, additional, Sung, Anthony D., additional, Chao, Nelson J., additional, Rizzieri, David A., additional, and Sarantopoulos, Stefanie, additional

Published
2019
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8. Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd

Author

Jia, Wei, primary, Poe, Jonathan C., additional, Su, Hsuan, additional, Matsushima, Glenn K, additional, Rathmell, Jeffrey, additional, Imai, Kazuhiro, additional, Reyes, Nancy J, additional, Cardona, Diana M, additional, Anand, Sarah, additional, Deoliveira, Divino, additional, Li, Zhiguo, additional, Saban, Daniel R, additional, Chen, Benny J., additional, Chao, Nelson J., additional, and Sarantopoulos, Stefanie, additional

Published
2016
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9. All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Author

Poe, Jonathan C., primary, Jia, Wei, additional, Su, Hsuan, additional, Li, Zhiguo, additional, Hakim, Frances T., additional, Pavletic, Steven Z., additional, Rose, Jeremy J., additional, Rizzieri, David A, additional, Yang, Yiping, additional, Chen, Benny J., additional, Anand, Sarah, additional, Ritz, Jerome, additional, Siebel, Christian W., additional, Chao, Nelson J., additional, Maillard, Ivan, additional, and Sarantopoulos, Stefanie, additional

Published
2016
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10. Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)

Author

Poe, Jonathan C., primary, Jia, Wei, additional, Li, Zhiguo, additional, Hakim, Frances T., additional, Pavletic, Steven Z., additional, Rose, Jeremy J., additional, Rizzieri, David A., additional, Yang, Yiping, additional, Chen, Benny J., additional, Green, Michael, additional, Anand, Sarah, additional, Siebel, Christian W., additional, Maillard, Ivan, additional, Chao, Nelson J., additional, and Sarantopoulos, Stefanie, additional

Published
2015
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11. High Dose BCNU/Melphalan Preparative Regimen Doubles Event Free Survival of Myeloma Patients Undergoing Autologous Transplantation

Author

Gasparetto, Cristina, primary, Bacon, Wendi A., additional, Doan, Phuong, additional, Rizzieri, David A., additional, Horwitz, Mitchell E., additional, Chute, John P., additional, Sullivan, Keith M., additional, Yopp, Amanda, additional, Li, Zhiguo, additional, Chao, Nelson J., additional, and Long, Gwynn D., additional

Published
2011
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12. High Complete Response Rates with Dose Dense/Dose Intense Chemotherapy Plus Radioimmunotherapy in High Risk Diffuse Large B Cell and Mantle Cell Lymphoma

Author

Beaven, Anne W, primary, Rizzieri, David A., additional, Powell, Zachary, additional, Li, Zhiguo, additional, Alton, Peggy, additional, Warzecho, Julie, additional, Diehl, Louis F., additional, Moore, Joseph O., additional, de Castro, Carlos Manuel, additional, and Gockerman, Jon P., additional

Published
2011
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13. Prospective, Biological Randomized Study of T-Cell Depleted Nonmyeloablative Allogeneic Transplantation From HLA-Matched Related, Unrelated or Haploidentical Donors for Patients with Hematologic Malignancies

Author

Kanda, Junya, primary, Long, Gwynn D., additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Sullivan, Keith M., additional, Chute, John P., additional, Morris, Ashley, additional, Li, Zhiguo, additional, Chao, Nelson J., additional, and Rizzieri, David A., additional

Published
2010
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14. The Gamma Gap: A Point-of-Care Test That Correlates with Disease Burden and Treatment Response in Multiple Myeloma

Author

Dupuis, Megan Murray, Li, Zhiguo, Tuchman, Sascha A, and Kang, Yubin

Abstract

Introduction:Multiple Myeloma (MM) is the malignant neoplasm of plasma cells and is often characterized by the production of large amounts of non-functional, monoclonal immunoglobulins (M spike) that serve as a surrogate for tumor burden and treatment response. Currently, the gold standard for monitoring response status is serum and urine protein electrophoresis (SPEP and UPEP, respectively), which quantify the M spike. Unfortunately, the turnaround time for these tests is not immediate; SPEP is ~3 days and UPEP ~7 days. Waiting for news on chemotherapeutic response is a significant psychological stressor for cancer patients and their families, and moreover leads to uncertainty when a clinician is face-to-face with a patient and PEP data are not yet available. Currently the lack of a validated, inexpensive, same-day point-of-care response assessment represents an unmet need. One such test may be the gamma gap (GG). The GG is the calculated difference between a patient's total serum protein and albumin. In patients with a substantial serum M-spike, the GG is typically elevated since excess myeloma-derived immunoglobulins elevate total protein but not albumin. Measurements of both total protein and albumin can be can be obtained from a standard comprehensive metabolic profile (CMP) or equivalent within 1 hour after blood draw. We hypothesized that the GG is a reliable indicator of disease burden and therapeutic response, and can be used as a surrogate point-of-care test for assessing response status in myeloma patients while awaiting SPEP results.

Published
2017
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15. All-TransRetinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Author

Poe, Jonathan C., Jia, Wei, Su, Hsuan, Li, Zhiguo, Hakim, Frances T., Pavletic, Steven Z., Rose, Jeremy J., Rizzieri, David A, Yang, Yiping, Chen, Benny J., Anand, Sarah, Ritz, Jerome, Siebel, Christian W., Chao, Nelson J., Maillard, Ivan, and Sarantopoulos, Stefanie

Abstract

Allogeneic hematopoietic stem cell transplantation (HCT)-related immune pathology severely limits patient (Pt) survival, largely due to infections. Chronic graft versus host disease (cGVHD) Pts are particularly immune incompetent with impaired memory B cell responses. Paradoxically, cGVHD Pts are hypogammaglobulinemic and yet are variably immune tolerant with potentially pathogenic alloantibodies frequently produced. B cells with marginal zone (MZ)-like properties are expanded in cGVHD Pts with high BAFF/B-cell ratios (rev. Sarantopoulos, Blood2015), similar to findings in BAFF-overexpressing mice. We previously found that the increased BCR responsiveness of cGVHD B cells depended on NOTCH2 signaling, since a specific monoclonal antibody (Genentech) blocked hyperactivation (ASH 2015 oral abstract: Blood. 2015. 126:145). Our current objective is to define the molecular defects underlying this aberrant NOTCH2-BCR axis.

Published
2016
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