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7 results on '"Lee, Nicole"'

1. Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease

Author

Docampo, Melissa D., da Silva, Marina B., Lazrak, Amina, Nichols, Katherine B., Lieberman, Sophia R., Slingerland, Ann E., Armijo, Gabriel K., Shono, Yusuke, Nguyen, Chi, Monette, Sebastien, Dwomoh, Emmanuel, Lee, Nicole, Geary, Clair D., Perobelli, Suelen M., Smith, Melody, Markey, Kate A., Vardhana, Santosha A., Kousa, Anastasia I., Zamir, Eli, Greenfield, Itamar, Sun, Joseph C., Cross, Justin R., Peled, Jonathan U., Jenq, Robert R., Stein-Thoeringer, Christoph K., and van den Brink, Marcel R.M.

Published
2022
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2. Highly Selective Irreversible ITK Inhibitor Cpi-818 Reduces Acute Graft-Versus Host Disease

Author

Lindner, Sarah, primary, Lee, Nicole, additional, Armijo, Gabriel K, additional, Burgos da Silva, Marina D, additional, Herrera, Pamela S, additional, Nguyen, Chi L, additional, Dwomoh, Emmanuel A, additional, Ghale, Romina, additional, Smith, Melody, additional, Perales, Miguel-Angel, additional, Markey, Kate A, additional, Buggy, Joseph J, additional, Janc, James W, additional, and van den Brink, Marcel, additional

Published
2021
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3. MAIT and Vδ2 Unconventional T Cells Predict Favorable Outcome after Allogeneic HCT and Are Supported By a Diverse Intestinal Microbiome

Author

Andrlova, Hana, primary, Miltiadous, Oriana, additional, Dai, Anqi, additional, Gardner, Rui, additional, El Daker, Sary, additional, Slingerland, John B, additional, Giardina, Paul A, additional, Clurman, Annelie, additional, Gomes, Antonio L.C., additional, Nguyen, Chi L., additional, Burgos da Silva, Marina D, additional, DeWolf, Susan, additional, Armijo, Gabriel K, additional, Lee, Nicole, additional, Zappasodi, Roberta, additional, Fontana, Emily, additional, Ponce, Doris M, additional, Cho, Christina, additional, Giralt, Sergio A, additional, Devlin, Sean M, additional, Peled, Jonathan U, additional, Cross, Justin, additional, Perales, Miguel-Angel, additional, Godfrey, Dale I, additional, van den Brink, Marcel, additional, and Markey, Kate A, additional

Published
2021
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4. Pilot Study of Longitudinal Geriatric Assessment and Neurocognitive Evaluation in CAR T-Cell Therapy for Older Patients with Relapsed Refractory, Large B-Cell Lymphoma

Author

Lin, Richard J., Kim, Soo Jung, Correa, Denise, Elko, Theresa A, Lobaugh, Stephanie, Baser, Raymond, Koch, Adrian, Hanley, Danielle M, Palomba, M. Lia, Dahi, Parastoo B., Scordo, Michael, Shah, Gunjan L., Sauter, Craig S, Nagel, Katherine, Engstler, Danielle, Lee, Nicole, Pavkovic, Emma, Park, Jae H., Perales, Miguel-Angel, Devlin, Sean M., Korc-Grodzicki, Beatriz, Hamlin, Paul A., and Giralt, Sergio A.

Abstract

Introduction:Chimeric antigen receptor T-cell (CAR T) therapy is increasingly utilized for older patients with relapsed refractory, large b-cell lymphoma (LBCL) with promising efficacy. However, the feasibility of conducting serial geriatric assessments with appropriate management has not been examined in this vulnerable population of patients. Moreover, the short-term and long-term impact of CAR T-cell therapy on the older patient's overall physical and neurocognitive functioning remains unknown.

Published
2023
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5. Low CD117 Expression Identifies Hematopoietic Stem Cell Subsets with Enhanced Lymphoid Potential in Mice and Humans

Author

Elias, Harold K, Mitra, Sneha, Gipson, Brianna, Burgos da Silva, Marina, Lee, Nicole, Ali, Mohamed A.E., Grassman, Simon, Kousa, Anastasia, DeWolf, Susan, Park, Christopher Y., Sun, Joseph, Leslie, Christina, Bhandoola, Avinash, and van den Brink, Marcel R.M.

Abstract

Background:Hematopoietic stem cells (HSCs) with multilineage potential are critical for effective de novo T-cell generation and thymic recovery, restoring the adaptive immune system after Hematopoietic Cell Transplantation (HCT). Recent studies have brought new insights into functional heterogeneity within HSCs, revealing an organized and predictable framework governing the adoption of lineage-restricted fates. However, the gene-regulatory networks underlying lymphoid determination and their conservation with aging in HSCs need to be elucidated. This study aims to comprehensively investigate the molecular profile of young and old HSCs and identify HSC subsets with multilineage transcriptional programs.

Published
2023
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