Search

Your search keyword '"López, Antonio"' showing total 15 results
Start Over Author "López, Antonio" Journal blood
15 results on '"López, Antonio"'

1. Laboratory Prognostic Index (LaPI) in Diffuse Large B Cell Lymphoma: Validation Study on Behalf of the Spanish Lymphoma Cooperative Group (GEL-TAMO)

Author

Martín Moro, Fernando, Bento De Miguel, Leyre, Marquet Palomanes, Juan, Gutierrez, Antonio, Diaz-Lopez, Antonio, Sanchez, Jose M., Garcia Vela, Jose Antonio, Salar, Antonio, Cordoba, Raul, Novelli, Silvana, Rodriguez-Salazar, Maria J., González de Villambrosia, Sonia, Del Campo, Raquel, Luzardo Henriquez, Hugo Daniel, Garcia, Daniel, Sancho, Juan-Manuel, Abrisqueta, Pau, Martín García-Sancho, Alejandro, and Bastos-Oreiro, Mariana

Published
2022
Full Text
View/download PDF

2. Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients

Author

Quijano, Sandra, López, Antonio, Rasillo, Ana, Barrena, Susana, Luz Sánchez, Maria, Flores, Juan, Fernández, Carlos, Sayagués, José María, Osuna, Carlos Salvador, Fernández, Nuria, González, Marcos, Giraldo, Pilar, Giralt, Manuel, Pérez, Maria Carmen, Martin-Antoran, José Manuel, Gutiérrez, Oliver, Perdiguer, Luis, Díaz Mediavilla, Joaquín, González Silva, Manuel, Asensio del Rio, Agustín, Cerveró, Carlos, Guerra, José Luis, Butrón, Rosario, del Carmen García, Maria, Almeida, Julia, and Orfao, Alberto

Published
2008
Full Text
View/download PDF

5. Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome

Author

Muñiz, Carmen, Martín-Martín, Lourdes, López, Antonio, Sánchez-González, Blanca, Salar, Antonio, Almeida, Julia, Sancho, Juan-Manuel, Ribera, José María, Heras, Cecilia, Peñalver, Francisco Javier, Gómez, Marta, González-Barca, Eva, Alonso, Natalia, Navarro, Belén, Olave, Teresa, Sala, Francisco, Conde, Eulogio, Márquez, José Antonio, Cabezudo, Elena, Cladera, Antonia, García-Malo, María, Caballero, María Dolores, and Orfao, Alberto

Published
2014
Full Text
View/download PDF

7. Validation of the NCCN-IPI for Diffuse Large B-Cell Lymphoma (DLBCL) in a Nation-Wide Spanish Series of 1885 Patients. the Geltamo-IPI Project

Author

Montalbán, Carlos, primary, Díaz-López, Antonio, additional, Garrote Santana, Heidys, additional, Freue, Julián Matias, additional, López, Lourdes, additional, De Oña, Raquel, additional, Martín Moreno, Ana M, additional, López-Guillermo, Armando, additional, Dlouhi, Ivan, additional, Rovira, Jordina, additional, Rodríguez, Mario, additional, Sánchez Pina, José Maria, additional, Alonso, Sara, additional, Martín García, Alejandro, additional, Novelli, Silvana, additional, Sancho, Juan-Manuel, additional, García, Olga, additional, Salar, Antonio, additional, Gutierrez, Antonio, additional, Bastos, Mariana, additional, Rodriguez-Salazar, Maria, additional, Fernández, Ruben, additional, Domínguez, Juan F., additional, Queizán, Jose A., additional, González de Villambrosia, Sonia, additional, Córdoba, Raúl, additional, Abraira, Victor, additional, Rodríguez, Jose, additional, and Garcia, Juan F., additional

Published
2015
Full Text
View/download PDF

8. Geltamo-IPI Distinctly Identifies a Very High Risk Group in Difuse Large B-Cell Lymphoma (DLBCL) of Non B-Germinal-Center Origin Treated with Chemo-Immunotherapy

Author

Montalban, Carlos, Diaz-Lopez, Antonio, Martín, Alejandro, Baile, Monica, Sanchez, Jose M., Sancho, Juan-Manuel, García, Olga, Novelli, Silvana, Monter Rovira, Ana, Salar, Antonio, Bastos, Mariana, Gutierrez, Antonio, Cordoba, Raul, Arquero, Teresa, González de Villambrosia, Sonia, Barranco, Gilberto, de Oña, Raquel, Hong, Azueg, Casanova, Maria, Lopez-Guillermo, Armando, Rodriguez-Salazar, Maria J., Dominguez, Juan F., Fernandez, Ruben, Queizan, Jose Antonio, Rodriguez, Jose, Abraira, Victor, and Garcia, Juan F.

Published
2017
Full Text
View/download PDF

9. Evaluation of the MD Anderson Tumor Score and Their Tumor Related Prognostic Variables in the Rituximab Era

Author

Gutierrez, Antonio, Bento, Leyre, Montalban, Carlos, Diaz-Lopez, Antonio, Garrote, Heidys, Freue, Julian, Lopez, Lourdes, Oña, Raquel, Martin Moreno, Ana Maria, Lopez-Guillermo, Armando, Dlouhy, Ivan, Rovira, Jordina, Rodriguez, Mario, Sanchez, Jose M., Baile, Monica, Martín, Alejandro, Novelli, Silvana, Sancho, Juan Manuel, García, Olga, Salar, Antonio, Bastos, Mariana, Rodriguez-Salazar, Maria J., Fernandez, Ruben, Dominguez, Juan F., Queizan, Jose Antonio, González de Villambrosia, Sonia, Cordoba, Raul, Abraira, Victor, Garcia, Juan F., and Rodriguez, Jose

Published
2017
Full Text
View/download PDF

13. Indolent Systemic Mast Cell Disease in Adults: Immunophenotypic Characterization of Bone Marrow Mast Cells and Its Diagnostic Implications

Author

Escribano, Luis, primary, Orfao, Alberto, additional, Dı́az-Agustin, Beatriz, additional, Villarrubia, Jesús, additional, Cerveró, Carlos, additional, López, Antonio, additional, Marcos, Marı́a A. Garcı́a, additional, Bellas, Carmen, additional, Fernández-Cañadas, Serafı́n, additional, Cuevas, Manuela, additional, Sánchez, Alberto, additional, Velasco, José L., additional, Navarro, José Luis, additional, and Miguel, Jesús F. San, additional

Published
1998
Full Text
View/download PDF

14. IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

Author

Maloney, David G., primary, Grillo-López, Antonio J., additional, White, Christine A., additional, Bodkin, David, additional, Schilder, Russell J., additional, Neidhart, James A., additional, Janakiraman, Nalini, additional, Foon, Kenneth A., additional, Liles, Tina-Marie, additional, Dallaire, Brian K., additional, Wey, Ken, additional, Royston, Ivor, additional, Davis, Thomas, additional, and Levy, Ronald, additional

Published
1997
Full Text
View/download PDF

15. Apoptotic and Multi-Drug Resistance Profile in Elderly AML Patients.

Author

Vidriales, Maria-Belen, Suarez, Lilia, García-Laraña, José, López, Antonio, Moreno, María José, Martinez, Rafael, Tormo, Mar, Lavilla, Esperanza, López-Berges, Consuelo, de Santiago, María, San Miguel, Jesús F., and Orfao, Alberto

Abstract

Elderly AML patients have an unfavorable prognosis with frequent resistance of leukemic cells to chemotherapy. The expression of proteins related with apoptosis and multi-drug resistance have been involved in chemotherapeutic resistance in AML; however, these proteins are not only expressed on leukemic but also on normal cells. Moreover, within leukemic cells, different stages of maturation may occur. The aim of the present study was to evaluate the expression of proteins related to apoptosis (APO 2.7, bax, and bcl-2), and drug resistance (P-gp, MRP, LRP) in a series of 117 elderly AML patients (median age of 70) uniformly treated according with the Spanish Pethema cooperative group protocol (LMA >65). 63 patients (54%) achieved complete remission (CR), with a median relapse free survival (RFS) of 9.2 months. In the bone marrow (BM) pre-treatment, we performed a four-color staining technique (APO2.7, bax or bcl-2 with CD32/CD34/CD45; and P-gp, MRP, or LRP with CD34/CD19/CD33), allowing the identification of myeloid blast cells, and the discrimination between stages of maturation of blast cell subsets. Samples were acquired on a FACSCalibur flow cytometer (Becton/Dickinson), and appropriate controls were used in each individual sample and, accordingly, antigen expression in individual cell samples was quantified as relative fluorescence intensity (RFI) (ratio blast cell/control mean channel fluorescence value). Our results showed that the level of expression of MRP and LRP was significantly higher (mean±SD of MFI 2.0±0.75 vs 2.7±1.87 and 4.5±2.2 vs 7.0±6.2, respectively -p <0.03-) in cases that did not achieved CR with one or two cycles of chemotherapy. Although different patterns of expression of apoptosis or drug resistance-associated proteins were detected according with the stage of maturation on myeloid blast cells, we did’t found any other correlation between levels of bcl-2, bax, APO 2.7, bcl-2/bax ratio or MDR and probability of achieving morphological CR. In addition, CD34 expression on blast cells had also significant influence on response (CR was achieved in 81% of CD34 negative cases vs only 46% of CD34 positive cases; p= 0.005). We didn’t found any influence of apoptosis and/or drug-resistance proteins expression in relapse rate nor RFS. Variables influencing RFS were age (p=0.04), and number of cycles to achieve CR (p=0.01); while only WBC count (p=0.05) influenced overall survival (OS). We conclude that MRP and LRP could have a role in the resistance to induction treatment in elderly AML patients but not in RFS or OS.

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results