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1. Human and Simian Immunodeficiency Viruses De-Regulate Early Hematopoiesis through a Novel Nef/PPAR-γ/STAT5 Signaling Pathway

Author

Prost, Stéphane, primary, le Dantec, Mikael, primary, Augé, Sylvie, primary, Le GRAND, Roger, primary, Derdouch, Sonia, primary, Auregan, Gwenaelle, primary, Déglon, Nicole, primary, Relouzat, Francis, primary, Aubertin, Anne-Marie, primary, Maillere, Bernard, primary, Dusanter-fourt, Isabelle, primary, and Kirszenbaum, Marek, primary

Published
2008
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2. Human and Simian Immunodeficiency Viruses De-Regulate Early Hematopoiesis through a Novel Nef/PPAR-γ/STAT5 Signaling Pathway

Author

Marek Kirszenbaum, Anne-Marie Aubertin, Roger Le Grand, Bernard Maillere, Stephane Prost, Nicole Déglon, Sylvie Augé, Isabelle Dusanter-Fourt, Sonia Derdouch, Francis Relouzat, Mikael Le Dantec, and Gwenaelle Auregan

Subjects
biology, Viral protein, Immunology, virus diseases, STAT5B, Cell Biology, Hematology, Simian immunodeficiency virus, medicine.disease_cause, medicine.disease, Biochemistry, Virology, Haematopoiesis, Downregulation and upregulation, medicine, biology.protein, Signal transduction, STAT5, Immunodeficiency
Abstract

Infection of primates by HIV-1 and SIV induces multiple hematological abnormalities of central hematopoietic origin. Although these defects greatly contribute to the pathophysiology of HIV-1 infection, the molecular basis for altered BM function remains unknown. Here we show that when cynomolgus macaques were infected with SIV, the multipotent potential of their hematopoietic progenitor cells was lost, and this correlated with down regulation of STAT5A and STAT5B expression. However, forced expression of STAT5B entirely rescued the multipotent potential of the hematopoietic progenitor cells. In addition, an accessory viral protein required for efficient SIV and HIV replication and pathogenicity, “Negative factor” (Nef), was essential for

Published
2008
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