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1. LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation

Author

Moore, Jamie A, Mistry, Jayna J, Hellmich, Charlotte, Horton, Rebecca H, Wojtowicz, Edyta, Jibril, Aisha, Wileman, Tom, Jefferson, Matthew, Beraza, Naiara, Bowles, Kristian M, and Rushworth, Stuart A

Abstract

The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for uncleared apoptotic debris in regulating the immunologic response to, and growth of, solid tumors. LC3-associated phagocytosis (LAP) maintains tissue homeostasis by regulating immune responses, such as tumor immunity. Here we investigate the role of LAP in macrophage within the BM microenvironment of AML.

Published
2021
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