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Your search keyword '"Hulbert, Monica L."' showing total 27 results
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27 results on '"Hulbert, Monica L."'

3. A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children

Author

Brousseau, David C., Scott, J. Paul, Badaki-Makun, Oluwakemi, Darbari, Deepika S., Chumpitazi, Corrie E., Airewele, Gladstone E., Ellison, Angela M., Smith-Whitley, Kim, Mahajan, Prashant, Sarnaik, Sharada A., Casper, T. Charles, Cook, Lawrence J., Dean, J. Michael, Leonard, Julie, Hulbert, Monica L., Powell, Elizabeth C., Liem, Robert I., Hickey, Robert, Krishnamurti, Lakshmanan, Hillery, Cheryl A., Nimmer, Mark, and Panepinto, Julie A.

Published
2015
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4. Hydroxyurea Use Among Youth with Sickle Cell Anemia across Eight Care Centers within the United States

Author

Hildenbrand, Aimee K., primary, Eckrich, Daniel, additional, Lewis, Amanda M., additional, Schultz, Corinna L., additional, Alderfer, Melissa A., additional, Forrest, Christopher B., additional, Creary, Susan E., additional, Hulbert, Monica L., additional, Rao, Suchitra, additional, Christakis, Dimitri A., additional, and Crosby, Lori E., additional

Published
2022
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5. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease

Author

Hulbert, Monica L., McKinstry, Robert C., Lacey, JoAnne L., Moran, Christopher J., Panepinto, Julie A., Thompson, Alexis A., Sarnaik, Sharada A., Woods, Gerald M., Casella, James F., Inusa, Baba, Howard, Jo, Kirkham, Fenella J., Anie, Kofi A., Mullin, Jonathan E., Ichord, Rebecca, Noetzel, Michael, Yan, Yan, Rodeghier, Mark, and DeBaun, Michael R.

Published
2011
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7. Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia

Author

Fields, Melanie E., primary, Guilliams, Kristin P., additional, Ragan, Dustin, additional, Binkley, Michael M., additional, Mirro, Amy, additional, Fellah, Slim, additional, Hulbert, Monica L., additional, Blinder, Morey, additional, Eldeniz, Cihat, additional, Vo, Katie, additional, Shimony, Joshua S., additional, Chen, Yasheng, additional, McKinstry, Robert C., additional, An, Hongyu, additional, Lee, Jin-Moo, additional, and Ford, Andria L., additional

Published
2019
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8. Increased Volume and Distinct Pattern of Silent Cerebral Infarcts in Healthy, Young Adults with Sickle Cell Trait

Author

Ford, Andria L, primary, Fields, Melanie E, additional, Guilliams, Kristin P, additional, Ragan, Dustin K, additional, Yasheng, Chen, additional, Guillaume, Georges, additional, Shimony, Joshua S, additional, Vo, Katie D, additional, Blinder, Morey, additional, King, Allison, additional, Hulbert, Monica L, additional, McKinstry, Robert C, additional, and An, Hongyu, additional

Published
2017
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14. Elevations in MR Measurements of Whole Brain and Regional Cerebral Blood Flow and Oxygen Extraction Fraction Suggest Cerebral Metabolic Stress in Children with Sickle Cell Disease Unaffected By Overt Stroke

Author

Fields, Melanie E., primary, Guilliams, Kristin P., additional, Ragan, Dustin, additional, Eldeniz, Cihat, additional, Binkley, Michael, additional, Hulbert, Monica L., additional, Vo, Katie D., additional, McKinstry, Robert, additional, Shimony, Joshua, additional, An, Hongyu, additional, Ford, Andria, additional, and Lee, Jin-Moo, additional

Published
2015
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21. A Multi-Center Randomized Controlled Trial of Intravenous Magnesium for Sickle Cell Pain Crisis in Children

Author

Brousseau, David C., primary, Scott, J. Paul, additional, Badaki, Oluwakemi, additional, Darbari, Deepika S., additional, Chumpitazi, Corrie, additional, Airewele, Gladstone E., additional, Ellison, Angela M., additional, Smith-Whitley, Kim, additional, Mahajan, Prashant, additional, Sarnaik, Sharada A., additional, Casper, T Charles, additional, Cook, Larry J., additional, Dean, Michael, additional, Leonard, Julie, additional, Hulbert, Monica L., additional, Powell, Elizabeth, additional, Liem, Robert I., additional, Hickey, Robert, additional, Krishnamurti, Lakshmanan, additional, Hillery, Cheryl A., additional, and Panepinto, Julie A., additional

Published
2014
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23. Health-Related Quality of Life in Children with Sickle Cell Disease: Impact of Blood Transfusion Therapy

Author

Beverung, Lauren M, primary, Strouse, John J., additional, Hulbert, Monica L., additional, Neville, Kathleen A, additional, Liem, Robert I., additional, Inusa, Baba PD, additional, Fuh, Beng, additional, King, Allison, additional, Meier, Emily R., additional, Casella, James F., additional, DeBaun, Michael R., additional, and Panepinto, Julie A., additional

Published
2014
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27. Normalization of cerebral hemodynamics after hematopoietic stem cell transplant in children with sickle cell disease

Author

Hulbert, Monica L., Fields, Melanie E., Guilliams, Kristin P., Bijlani, Priyesha, Shenoy, Shalini, Fellah, Slim, Towerman, Alison S., Binkley, Michael M., McKinstry, Robert C., Shimony, Joshua S., Chen, Yasheng, Eldeniz, Cihat, Ragan, Dustin K., Vo, Katie, An, Hongyu, Lee, Jin-Moo, and Ford, Andria L.

Abstract

Children with sickle cell disease (SCD) demonstrate cerebral hemodynamic stress and are at high risk of strokes. We hypothesized that curative hematopoietic stem cell transplant (HSCT) normalizes cerebral hemodynamics in children with SCD compared with pre-transplant baseline. Whole-brain cerebral blood flow (CBF) and oxygen extraction fraction (OEF) were measured by magnetic resonance imaging 1 to 3 months before and 12 to 24 months after HSCT in 10 children with SCD. Three children had prior overt strokes, 5 children had prior silent strokes, and 1 child had abnormal transcranial Doppler ultrasound velocities. CBF and OEF of HSCT recipients were compared with non-SCD control participants and with SCD participants receiving chronic red blood cell transfusion therapy (CRTT) before and after a scheduled transfusion. Seven participants received matched sibling donor HSCT, and 3 participants received 8 out of 8 matched unrelated donor HSCT. All received reduced-intensity preparation and maintained engraftment, free of hemolytic anemia and SCD symptoms. Pre-transplant, CBF (93.5 mL/100 g/min) and OEF (36.8%) were elevated compared with non-SCD control participants, declining significantly 1 to 2 years after HSCT (CBF, 72.7 mL/100 g per minute; P = .004; OEF, 27.0%; P = .002), with post-HSCT CBF and OEF similar to non-SCD control participants. Furthermore, HSCT recipients demonstrated greater reduction in CBF (−19.4 mL/100 g/min) and OEF (−8.1%) after HSCT than children with SCD receiving CRTT after a scheduled transfusion (CBF, −0.9 mL/100 g/min; P = .024; OEF, −3.3%; P = .001). Curative HSCT normalizes whole-brain hemodynamics in children with SCD. This restoration of cerebral oxygen reserve may explain stroke protection after HSCT in this high-risk patient population.

Published
2022
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