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Background:

Introduction: Polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF) are myeloproliferative neoplasms (MPNs) with impact on patients that include cytopenias, vascular risk, and disease specific symptom burden. Fatigue is the most commonly reported symptom among MPN patients, contributing to a reduced overall quality of life (QoL). Fatigue and reduced QoL are often left unresolved with current pharmacologic therapy. Our prior work has demonstrated the feasibility of online-streamed yoga and its preliminary effects for improving total symptom burden (including fatigue) in MPN patients. The purpose of this study was to further examine the effects of a 12-wk online yoga intervention for fatigue and QoL in MPN patients as compared to a wait-list control group as well as the feasibility of collecting remote blood samples, for remote assessment of corresponding biomarkers, in a national sample of MPN patients.