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Your search keyword '"Flores, Maria"' showing total 9 results
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9 results on '"Flores, Maria"'

3. Marsun, a Phase III, Multicenter, Open Label, Randomized, Controlled Study Investigating Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients with Relapsed or Refractory Marginal Zone Lymphoma (R/R MZL)

Author

Thieblemont, Catherine, Conconi, Annarita, Buske, Christian, Luminari, Stefano, Dreyling, Martin, da Silva, Maria Gomes, Andre, Marc, Flores, Maria, Brahami-Aissou, Karima, Cony-Makhoul, Pascale, and Carras, Sylvain

Abstract

Background

Published
2023
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4. Clinical Characteristics and Prognosis in South-American Patients with Myelodysplastic Syndrome: A Multicenter Study

Author

Belli, Carolina, primary, Feitosa Pinheiro, Ronald, additional, Flores, Maria Gabriela, additional, Magalhaes, Silvia M. M., additional, Kornblihtt, Laura, additional, Enrico, Alicia, additional, Cordeiro, Juliana, additional, Basquiera, Ana Lisa, additional, Cavalcante de Andrade Silva, Marcela, additional, da Silva Tanizawa, Roberta, additional, Pintos, Noemi, additional, Alfonso, Graciela, additional, Arbelbide, Jorge, additional, Sakamoto, Francisco, additional, Watman, Nora, additional, Valladares Ticona, Ximena, additional, Larripa, Irene B, additional, Undurraga, Soledad S., additional, and Velloso, Elvira RP, additional

Published
2014
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6. Zebrafish runx1promoter-EGFP transgenics mark discrete sites of definitive blood progenitors

Author

Yi Ni Lam, Enid, Chau, Jackie Y.M., Kalev-Zylinska, Maggie L., Fountaine, Timothy M., Mead, R. Scott, Hall, Christopher J., Crosier, Philip S., Crosier, Kathryn E., and Vega Flores, Maria

Abstract

The transcription factor Runx1 is essential for the development of definitive hematopoietic stem cells (HSCs) during vertebrate embryogenesis and is transcribed from 2 promoters, P1 and P2, generating 2 major Runx1 isoforms. We have created 2 stable runx1promoter zebrafish-transgenic lines that provide insight into the roles of the P1 and P2 isoforms during the establishment of definitive hematopoiesis. The Tg(runx1P1:EGFP) line displays fluorescence in the posterior blood island, where definitive erythromyeloid progenitors develop. The Tg(runx1P2:EGFP) line marks definitive HSCs in the aorta-gonad-mesonephros, with enhanced green fluorescent protein–labeled cells later populating the pronephros and thymus. This suggests that a function of runx1promoter switching is associated with the establishment of discrete definitive blood progenitor compartments. These runx1promoter–transgenic lines are novel tools for the study of Runx1 regulation and function in normal and malignant hematopoiesis. The ability to visualize and isolate fluorescently labeled HSCs should contribute to further elucidating the complex regulation of HSC development.

Published
2009
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9. Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors.

Author

Lam EY, Chau JY, Kalev-Zylinska ML, Fountaine TM, Mead RS, Hall CJ, Crosier PS, Crosier KE, and Flores MV

Subjects
Animals, Animals, Genetically Modified, Blotting, Southern, Cell Lineage, Embryo, Nonmammalian cytology, Embryo, Nonmammalian metabolism, Gene Expression Regulation, Developmental, Green Fluorescent Proteins genetics, Hematopoiesis, Immunoenzyme Techniques, In Situ Hybridization, Mesonephros cytology, Mesonephros embryology, Protein Isoforms, Zebrafish, Core Binding Factor Alpha 2 Subunit physiology, Erythroid Precursor Cells cytology, Green Fluorescent Proteins metabolism, Promoter Regions, Genetic genetics, Zebrafish Proteins physiology
Abstract

The transcription factor Runx1 is essential for the development of definitive hematopoietic stem cells (HSCs) during vertebrate embryogenesis and is transcribed from 2 promoters, P1 and P2, generating 2 major Runx1 isoforms. We have created 2 stable runx1 promoter zebrafish-transgenic lines that provide insight into the roles of the P1 and P2 isoforms during the establishment of definitive hematopoiesis. The Tg(runx1P1:EGFP) line displays fluorescence in the posterior blood island, where definitive erythromyeloid progenitors develop. The Tg(runx1P2:EGFP) line marks definitive HSCs in the aorta-gonad-mesonephros, with enhanced green fluorescent protein-labeled cells later populating the pronephros and thymus. This suggests that a function of runx1 promoter switching is associated with the establishment of discrete definitive blood progenitor compartments. These runx1 promoter-transgenic lines are novel tools for the study of Runx1 regulation and function in normal and malignant hematopoiesis. The ability to visualize and isolate fluorescently labeled HSCs should contribute to further elucidating the complex regulation of HSC development.

Published
2009
Full Text
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